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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28510

FusionGeneSummary for PPP5C_DCP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP5C_DCP1B
Fusion gene ID: 28510
HgeneTgene
Gene symbol

PPP5C

DCP1B

Gene ID

5536

196513

Gene nameprotein phosphatase 5 catalytic subunitdecapping mRNA 1B
SynonymsPP5|PPP5|PPTDCP1
Cytomap

19q13.32

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 5PP-Tprotein phosphatase TmRNA-decapping enzyme 1BDCP1 decapping enzyme homolog Bdecapping enzyme hDcp1b
Modification date2018052320180526
UniProtAcc

P53041

Q8IZD4

Ensembl transtripts involved in fusion geneENST00000012443, ENST00000391919, 
ENST00000280665, ENST00000397173, 
ENST00000541700, ENST00000540622, 
Fusion gene scores* DoF score5 X 3 X 4=605 X 4 X 5=100
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP5C [Title/Abstract] AND DCP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW262847PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000012443ENST00000280665PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-3CDSENST00000012443ENST00000397173PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-5UTRENST00000012443ENST00000541700PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-5UTRENST00000012443ENST00000540622PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-3CDSENST00000391919ENST00000280665PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-3CDSENST00000391919ENST00000397173PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-5UTRENST00000391919ENST00000541700PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+
3UTR-5UTRENST00000391919ENST00000540622PPP5Cchr19

46894039

-DCP1Bchr12

2062251

+

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FusionProtFeatures for PPP5C_DCP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP5C

P53041

DCP1B

Q8IZD4

Serine/threonine-protein phosphatase thatdephosphorylates a myriad of proteins involved in differentsignaling pathways including the kinases CSNK1E, ASK1/MAP3K5,PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2,SMAD proteins and TAU/MAPT. Implicated in wide ranging cellularprocesses, including apoptosis, differentiation, DNA damageresponse, cell survival, regulation of ion channels or circadianrhythms, in response to steroid and thyroid hormones, calcium,fatty acids, TGF-beta as well as oxidative and genotoxic stresses.Participates in the control of DNA damage response mechanisms suchas checkpoint activation and DNA damage repair through, forinstance, the regulation ATM/ATR-signaling and dephosphorylationof PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosisinduced by oxidative stress. Plays a positive role inadipogenesis, mainly through the dephosphorylation and activationof PPARG transactivation function. Also dephosphorylates andinhibits the anti-adipogenic effect of NR3C1. Regulates thecircadian rhythms, through the dephosphorylation and activation ofCSNK1E. May modulate TGF-beta signaling pathway by the regulationof SMAD3 phosphorylation and protein expression levels.Dephosphorylates and may play a role in the regulation ofTAU/MAPT. Through their dephosphorylation, may play a role in theregulation of ions channels such as KCNH2.{ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:14764652,ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15383005,ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16260606,ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:16892053,ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:19948726,ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22399290,ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23102700,ECO:0000269|PubMed:9000529}. May play a role in the degradation of mRNAs, both innormal mRNA turnover and in nonsense-mediated mRNA decay. Mayremove the 7-methyl guanine cap structure from mRNA molecules,yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP5C_DCP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP5C_DCP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP5C_DCP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP5C_DCP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource