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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28506

FusionGeneSummary for PPP4R2_KIDINS220

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP4R2_KIDINS220
Fusion gene ID: 28506
HgeneTgene
Gene symbol

PPP4R2

KIDINS220

Gene ID

151987

57498

Gene nameprotein phosphatase 4 regulatory subunit 2kinase D interacting substrate 220
SynonymsPP4R2ARMS|SINO
Cytomap

3p13

2p25.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 2kinase D-interacting substrate of 220 kDaankyrin repeat-rich membrane-spanning proteinkinase D-interacting substrate 220kDa
Modification date2018052320180523
UniProtAcc

Q9NY27

Q9ULH0

Ensembl transtripts involved in fusion geneENST00000356692, ENST00000295862, 
ENST00000394284, ENST00000495566, 
ENST00000418530, ENST00000256707, 
ENST00000427284, ENST00000473731, 
ENST00000319688, ENST00000436566, 
Fusion gene scores* DoF score5 X 2 X 5=502 X 2 X 2=8
# samples 52
** MAII scorelog2(5/50*10)=0log2(2/8*10)=1.32192809488736
Context

PubMed: PPP4R2 [Title/Abstract] AND KIDINS220 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-2H-A9GJ-01APPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000356692ENST00000418530PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000356692ENST00000256707PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000356692ENST00000427284PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000356692ENST00000473731PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000356692ENST00000319688PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5CDS-intronENST00000356692ENST00000436566PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5UTR-3CDSENST00000295862ENST00000418530PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5UTR-3CDSENST00000295862ENST00000256707PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5UTR-3CDSENST00000295862ENST00000427284PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5UTR-3CDSENST00000295862ENST00000473731PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5UTR-3CDSENST00000295862ENST00000319688PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5UTR-intronENST00000295862ENST00000436566PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000394284ENST00000418530PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000394284ENST00000256707PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000394284ENST00000427284PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000394284ENST00000473731PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000394284ENST00000319688PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5CDS-intronENST00000394284ENST00000436566PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000495566ENST00000418530PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000495566ENST00000256707PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000495566ENST00000427284PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000495566ENST00000473731PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
Frame-shitENST00000495566ENST00000319688PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-
5CDS-intronENST00000495566ENST00000436566PPP4R2chr3

73047309

+KIDINS220chr2

8919944

-

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FusionProtFeatures for PPP4R2_KIDINS220


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP4R2

Q9NY27

KIDINS220

Q9ULH0

Regulatory subunit of serine/threonine-proteinphosphatase 4 (PP4). May regulate the activity of PPP4C atcentrosomal microtubule organizing centers. Its interaction withthe SMN complex leads to enhance the temporal localization ofsnRNPs, suggesting a role of PPP4C in maturation of spliceosomalsnRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specificallydephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX)generated during DNA replication and required for DNA doublestrand break repair. Mediates RPA2 dephosphorylation by recruitingPPP4C to RPA2 in a DNA damage-dependent manner. RPA2dephosphorylation is required for the efficient RPA2-mediatedrecruitment of RAD51 to chromatin following double strand breaks,an essential step for DNA repair. {ECO:0000269|PubMed:10769191,ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045,ECO:0000269|PubMed:20154705}. Promotes a prolonged MAP-kinase signaling byneurotrophins through activation of a Rap1-dependent mechanism.Provides a docking site for the CRKL-C3G complex, resulting inRap1-dependent sustained ERK activation. May play an importantrole in regulating postsynaptic signal transduction through thesyntrophin-mediated localization of receptor tyrosine kinases suchas EPHA4. In cooperation with SNTA1 can enhance EPHA4-inducedJAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neuriteoutgrowth. May play a role in neurotrophin- and ephrin-mediatedneuronal outgrowth and in axon guidance during neural developmentand in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERKsignaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP4R2_KIDINS220


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP4R2_KIDINS220


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP4R2PPP4C, DDX20, GEMIN4, SMEK1, SMEK2, TIPRL, SRRM2, CLNS1A, IGBP1, NUBP2, TRA2B, DSTN, PLIN3, TPM1, CCT3, PAAF1, AMPD2, CCDC6, INPPL1, LRRC47, PSMA1, SF3A1, VASP, TSSC4, COMTD1, PPP2R4, LCMT1, PPME1, CUTA, DNAJA1, WDR55, SLC4A1AP, TRAPPC13, ELMSAN1, FAM133B, NPHP4, CT45A1, UBXN10, RNGTT, DHX38, CRAMP1L, ZNF785, USP10, FAM19A3, MARCKSL1, UXS1, USP15, SPAG9, MCM2, MCM4, MCM6, TRIM25KIDINS220MOB4, FN1, MYC, LGR4, HLA-DPA1, CEACAM21, CGRRF1, TXNDC15, VSIG4, EVA1C, FAF2, LDLRAD4, NTRK1, TMEM17, CLTC, GAK, KIF5B, PTPN1, RAB5C, RAB7A, RAB11A, VAPA, ATP6AP2, MYEF2, GOLT1B, GTSE1, CDH1, XPR1, FGFR2, VSIG1, MRAP2, B4GAT1, CLMP, MAGEE1, CD79B, TNFRSF1A, DKKL1, CDH5, MANSC1, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP4R2_KIDINS220


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP4R2_KIDINS220


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource