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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28502

FusionGeneSummary for PPP4R2_AHRR

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP4R2_AHRR
Fusion gene ID: 28502
HgeneTgene
Gene symbol

PPP4R2

AHRR

Gene ID

151987

57491

Gene nameprotein phosphatase 4 regulatory subunit 2aryl-hydrocarbon receptor repressor
SynonymsPP4R2AHH|AHHR|bHLHe77
Cytomap

3p13

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 2aryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor
Modification date2018052320180523
UniProtAcc

Q9NY27

A9YTQ3

Ensembl transtripts involved in fusion geneENST00000356692, ENST00000295862, 
ENST00000394284, ENST00000495566, 
ENST00000505113, ENST00000316418, 
ENST00000512529, ENST00000515206, 
ENST00000506456, 
Fusion gene scores* DoF score5 X 2 X 5=506 X 4 X 4=96
# samples 57
** MAII scorelog2(5/50*10)=0log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP4R2 [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-0369-01APPP4R2chr3

73047309

+AHRRchr5

422844

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000356692ENST00000505113PPP4R2chr3

73047309

+AHRRchr5

422844

+
Frame-shitENST00000356692ENST00000316418PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-5UTRENST00000356692ENST00000512529PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-intronENST00000356692ENST00000515206PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-intronENST00000356692ENST00000506456PPP4R2chr3

73047309

+AHRRchr5

422844

+
5UTR-3CDSENST00000295862ENST00000505113PPP4R2chr3

73047309

+AHRRchr5

422844

+
5UTR-3CDSENST00000295862ENST00000316418PPP4R2chr3

73047309

+AHRRchr5

422844

+
5UTR-5UTRENST00000295862ENST00000512529PPP4R2chr3

73047309

+AHRRchr5

422844

+
5UTR-intronENST00000295862ENST00000515206PPP4R2chr3

73047309

+AHRRchr5

422844

+
5UTR-intronENST00000295862ENST00000506456PPP4R2chr3

73047309

+AHRRchr5

422844

+
Frame-shitENST00000394284ENST00000505113PPP4R2chr3

73047309

+AHRRchr5

422844

+
Frame-shitENST00000394284ENST00000316418PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-5UTRENST00000394284ENST00000512529PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-intronENST00000394284ENST00000515206PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-intronENST00000394284ENST00000506456PPP4R2chr3

73047309

+AHRRchr5

422844

+
Frame-shitENST00000495566ENST00000505113PPP4R2chr3

73047309

+AHRRchr5

422844

+
Frame-shitENST00000495566ENST00000316418PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-5UTRENST00000495566ENST00000512529PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-intronENST00000495566ENST00000515206PPP4R2chr3

73047309

+AHRRchr5

422844

+
5CDS-intronENST00000495566ENST00000506456PPP4R2chr3

73047309

+AHRRchr5

422844

+

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FusionProtFeatures for PPP4R2_AHRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP4R2

Q9NY27

AHRR

A9YTQ3

Regulatory subunit of serine/threonine-proteinphosphatase 4 (PP4). May regulate the activity of PPP4C atcentrosomal microtubule organizing centers. Its interaction withthe SMN complex leads to enhance the temporal localization ofsnRNPs, suggesting a role of PPP4C in maturation of spliceosomalsnRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specificallydephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX)generated during DNA replication and required for DNA doublestrand break repair. Mediates RPA2 dephosphorylation by recruitingPPP4C to RPA2 in a DNA damage-dependent manner. RPA2dephosphorylation is required for the efficient RPA2-mediatedrecruitment of RAD51 to chromatin following double strand breaks,an essential step for DNA repair. {ECO:0000269|PubMed:10769191,ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045,ECO:0000269|PubMed:20154705}. Mediates dioxin toxicity and is involved in regulationof cell growth and differentiation. Represses the transcriptionactivity of AHR by competing with this transcription factor forheterodimer formation with the ARNT and subsequently binding tothe xenobiotic response element (XRE) sequence present in thepromoter regulatory region of variety of genes. Represses CYP1A1by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/orHDAC5. Autoregulates its expression by associating with its ownXRE site. {ECO:0000269|PubMed:17890447,ECO:0000269|PubMed:18172554}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP4R2_AHRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP4R2_AHRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP4R2PPP4C, DDX20, GEMIN4, SMEK1, SMEK2, TIPRL, SRRM2, CLNS1A, IGBP1, NUBP2, TRA2B, DSTN, PLIN3, TPM1, CCT3, PAAF1, AMPD2, CCDC6, INPPL1, LRRC47, PSMA1, SF3A1, VASP, TSSC4, COMTD1, PPP2R4, LCMT1, PPME1, CUTA, DNAJA1, WDR55, SLC4A1AP, TRAPPC13, ELMSAN1, FAM133B, NPHP4, CT45A1, UBXN10, RNGTT, DHX38, CRAMP1L, ZNF785, USP10, FAM19A3, MARCKSL1, UXS1, USP15, SPAG9, MCM2, MCM4, MCM6, TRIM25AHRRARNT, ESR1, HDAC4, HDAC5, ANKRA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP4R2_AHRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP4R2_AHRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource