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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2850

FusionGeneSummary for ARRDC3_ACSL4

check button Fusion gene summary
Fusion gene informationFusion gene name: ARRDC3_ACSL4
Fusion gene ID: 2850
HgeneTgene
Gene symbol

ARRDC3

ACSL4

Gene ID

57561

2182

Gene namearrestin domain containing 3acyl-CoA synthetase long chain family member 4
SynonymsTLIMPACS4|FACL4|LACS4|MRX63|MRX68
Cytomap

5q14.3

Xq23

Type of geneprotein-codingprotein-coding
Descriptionarrestin domain-containing protein 3TBP-2-like inducible membrane proteinalpha-arrestin 3long-chain-fatty-acid--CoA ligase 4LACS 4acyl-CoA synthetase 4fatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4
Modification date2018051920180527
UniProtAcc

Q96B67

O60488

Ensembl transtripts involved in fusion geneENST00000265138, ENST00000503192, 
ENST00000469796, ENST00000340800, 
ENST00000348502, ENST00000504383, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARRDC3 [Title/Abstract] AND ACSL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACSL4

GO:0006629

lipid metabolic process

9598324


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI133031ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000265138ENST00000469796ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000265138ENST00000340800ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000265138ENST00000348502ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000265138ENST00000504383ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000503192ENST00000469796ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000503192ENST00000340800ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000503192ENST00000348502ARRDC3chr5

90678709

+ACSL4chrX

108971287

-
intron-intronENST00000503192ENST00000504383ARRDC3chr5

90678709

+ACSL4chrX

108971287

-

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FusionProtFeatures for ARRDC3_ACSL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARRDC3

Q96B67

ACSL4

O60488

Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also otherG protein-coupled receptors (PubMed:20559325, PubMed:21982743,PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinationand endocytosis af activated ADRB2 and subsequent ADRB2degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4to ADRB2 (PubMed:20559325). Alternatively, may function as adapterprotein that does not play a major role in recruiting NEDD4 toADRB2, but rather plays a role in a targeting ADRB2 to endosomes(PubMed:23208550). {ECO:0000269|PubMed:20559325,ECO:0000269|PubMed:23208550}. Activation of long-chain fatty acids for both synthesisof cellular lipids, and degradation via beta-oxidation.Preferentially uses arachidonate and eicosapentaenoate assubstrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARRDC3_ACSL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARRDC3_ACSL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARRDC3_ACSL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneACSL4O60488DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4small moleculeapproved|investigational

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RelatedDiseases for ARRDC3_ACSL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARRDC3C1458155Mammary Neoplasms1CTD_human
TgeneACSL4C0011581Depressive disorder1CTD_human
TgeneACSL4C0033578Prostatic Neoplasms1CTD_human
TgeneACSL4C0036341Schizophrenia1PSYGENET
TgeneACSL4C0041834Erythema1CTD_human
TgeneACSL4C0993582Arthritis, Experimental1CTD_human
TgeneACSL4C1845672Mental Retardation, X-Linked 631CTD_human;UNIPROT
TgeneACSL4C2239176Liver carcinoma1CTD_human