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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28493

FusionGeneSummary for PPP3R1_WDR92

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP3R1_WDR92
Fusion gene ID: 28493
HgeneTgene
Gene symbol

PPP3R1

WDR92

Gene ID

5534

116143

Gene nameprotein phosphatase 3 regulatory subunit B, alphaWD repeat domain 92
SynonymsCALNB1|CNB|CNB1-
Cytomap

2p14

2p14

Type of geneprotein-codingprotein-coding
Descriptioncalcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type IWD repeat-containing protein 92WD repeat-containing protein Monadmonadtesticular secretory protein Li 67
Modification date2018052220180523
UniProtAcc

P63098

Q96MX6

Ensembl transtripts involved in fusion geneENST00000234310, ENST00000409752, 
ENST00000409377, 
ENST00000492039, 
ENST00000295121, ENST00000406245, 
ENST00000409164, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: PPP3R1 [Title/Abstract] AND WDR92 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3R1

GO:0033173

calcineurin-NFAT signaling cascade

22688515

HgenePPP3R1

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5KX-01APPP3R1chr2

68479257

-WDR92chr2

68371847

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000234310ENST00000492039PPP3R1chr2

68479257

-WDR92chr2

68371847

-
5CDS-5UTRENST00000234310ENST00000295121PPP3R1chr2

68479257

-WDR92chr2

68371847

-
5CDS-5UTRENST00000234310ENST00000406245PPP3R1chr2

68479257

-WDR92chr2

68371847

-
5CDS-5UTRENST00000234310ENST00000409164PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409752ENST00000492039PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409752ENST00000295121PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409752ENST00000406245PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409752ENST00000409164PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409377ENST00000492039PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409377ENST00000295121PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409377ENST00000406245PPP3R1chr2

68479257

-WDR92chr2

68371847

-
intron-5UTRENST00000409377ENST00000409164PPP3R1chr2

68479257

-WDR92chr2

68371847

-

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FusionProtFeatures for PPP3R1_WDR92


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP3R1

P63098

WDR92

Q96MX6

Regulatory subunit of calcineurin, a calcium-dependent,calmodulin stimulated protein phosphatase. Confers calciumsensitivity. {ECO:0000269|PubMed:26794871}. Seems to act as a modulator of apoptosis.{ECO:0000269|PubMed:16487927}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP3R1_WDR92


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP3R1_WDR92


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP3R1PPIA, CABP2, CABP5, CABP1, ELAVL1, PSMA7, PDE4D, TRAF3, PPP3CA, IQCB1, NAP1L2, TP53, FAM122A, FCGR2A, PDHB, RCAN3, PPP3CC, RCAN2, MYH7, TINF2, PPP3CB, RCAN1, DEFA1, TMEM200A, KLRG2, NFATC1, DGCR14, SMPD3, CDR2, ARHGAP22, IGFBP6, CRTC2, SRBD1, DGUOK, NUFIP1, TRIM25WDR92PARD6A, RPAP3, ZNF316, PMVK, S100A10, PPP6R2, ATG7, PPP3CB, TERF2IP, THG1L, UBE3C, WDR12, WDR4, VPS25, AREG, EXOSC8, PIH1D1, CCT6B, CCT3, PPP1CC, PPP1CA, PPP1R3A, PFDN2, HERC2, OFD1, NPHP1, XPO1, PPP1CB, SEC16A, POLR1A, POLR3E, PPEF2, UXT, ASB7, PPP1R7, DNAAF2, RUVBL2, TBC1D7, TSC1, URI1, CCT2, CCT4, CCT5, CCT6A, CCT7, CCT8, CSNK1A1, CTU1, DPCD, ECD, EFTUD2, FAM83H, PDRG1, PFDN6, POLR1C, POLR2A, POLR2B, POLR2C, POLR2E, POLR2H, POLR2M, POLR3A, PRPF8, RPAP2, RUVBL1, SEC13, SNRNP200, SPAG1, TANGO6, TCP1, TELO2, TSC2, WDR92, ZNHIT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP3R1_WDR92


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP3R1_WDR92


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP3R1C0036341Schizophrenia1PSYGENET
HgenePPP3R1C0149721Left Ventricular Hypertrophy1CTD_human
HgenePPP3R1C0151744Myocardial Ischemia1CTD_human