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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28492

FusionGeneSummary for PPP3R1_TTC27

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP3R1_TTC27
Fusion gene ID: 28492
HgeneTgene
Gene symbol

PPP3R1

TTC27

Gene ID

5534

55622

Gene nameprotein phosphatase 3 regulatory subunit B, alphatetratricopeptide repeat domain 27
SynonymsCALNB1|CNB|CNB1-
Cytomap

2p14

2p22.3

Type of geneprotein-codingprotein-coding
Descriptioncalcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type Itetratricopeptide repeat protein 27TPR repeat protein 27
Modification date2018052220180519
UniProtAcc

P63098

Q6P3X3

Ensembl transtripts involved in fusion geneENST00000234310, ENST00000409752, 
ENST00000409377, 
ENST00000317907, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 4 X 3=48
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP3R1 [Title/Abstract] AND TTC27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3R1

GO:0033173

calcineurin-NFAT signaling cascade

22688515

HgenePPP3R1

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A0YG-01APPP3R1chr2

68479257

-TTC27chr2

33007693

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000234310ENST00000317907PPP3R1chr2

68479257

-TTC27chr2

33007693

+
intron-3CDSENST00000409752ENST00000317907PPP3R1chr2

68479257

-TTC27chr2

33007693

+
intron-3CDSENST00000409377ENST00000317907PPP3R1chr2

68479257

-TTC27chr2

33007693

+

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FusionProtFeatures for PPP3R1_TTC27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP3R1

P63098

TTC27

Q6P3X3

Regulatory subunit of calcineurin, a calcium-dependent,calmodulin stimulated protein phosphatase. Confers calciumsensitivity. {ECO:0000269|PubMed:26794871}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTC27chr2:68479257chr2:33007693ENST00000317907+1320596_628593844RepeatNote=TPR 5
TgeneTTC27chr2:68479257chr2:33007693ENST00000317907+1320629_662593844RepeatNote=TPR 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-16100_1111171Calcium binding3
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-16141_1521171Calcium binding4
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-1631_421171Calcium binding1
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-1663_741171Calcium binding2
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-16128_1631171DomainEF-hand 4
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-1618_511171DomainEF-hand 1
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-1650_851171DomainEF-hand 2
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-1687_1221171DomainEF-hand 3
HgenePPP3R1chr2:68479257chr2:33007693ENST00000234310-16131_1361171RegionCalcineurin A binding
TgeneTTC27chr2:68479257chr2:33007693ENST00000317907+1320453_486593844RepeatNote=TPR 1
TgeneTTC27chr2:68479257chr2:33007693ENST00000317907+1320492_525593844RepeatNote=TPR 2
TgeneTTC27chr2:68479257chr2:33007693ENST00000317907+1320527_560593844RepeatNote=TPR 3
TgeneTTC27chr2:68479257chr2:33007693ENST00000317907+1320561_594593844RepeatNote=TPR 4


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FusionGeneSequence for PPP3R1_TTC27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PPP3R1_ENST00000234310_chr2_68479257_-_TTC27_ENST00000317907_chr2_33007693_+_252aa
MNAEAWNNLSTSTIRLKQKVKAFRTLQEALKCNTEHWQIWENYILTSTDVGEFSEAIKATHRLLDLRDKYKDVQVLKILVRAVIDGMTDR
SGDVATGLKGKLQELFGRVTSRVTNDGEIWRLTAHVTGNGQSEKPDENEKAFQCLSKAYKCDTQSNCWEKDITSFKEVVQRALGLAHVAI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PPP3R1_ENST00000234310_chr2_68479257_-_TTC27_ENST00000317907_chr2_33007693_+_756nt
ATGAATGCTGAAGCTTGGAACAATTTGTCAACTTCCTATATCCGATTAAAACAAAAAGTAAAAGCTTTTAGAACTTTACAAGAAGCTCTC
AAGTGTAACTATGAACACTGGCAGATTTGGGAAAACTACATCCTCACCAGCACTGACGTTGGGGAATTTTCAGAAGCCATTAAAGCTTAT
CACCGGCTCTTGGACTTACGTGACAAATACAAAGATGTTCAGGTCCTTAAAATTCTAGTCAGGGCAGTGATTGATGGGATGACTGATCGA
AGTGGAGATGTTGCAACTGGCCTCAAAGGAAAGCTGCAGGAGTTATTTGGCAGAGTGACTTCAAGAGTGACAAATGATGGAGAAATCTGG
AGGCTGTATGCCCACGTATATGGAAATGGGCAGAGTGAAAAGCCTGATGAAAATGAAAAGGCATTCCAGTGCCTCTCAAAGGCATACAAG
TGTGACACCCAGTCCAATTGTTGGGAGAAAGATATTACATCATTTAAGGAAGTTGTTCAAAGAGCCTTAGGACTTGCACATGTGGCCATA
AAATGCAGTAAAAACAAATCCAGTTCCCAAGAAGCTGTACAAATGCTTTCTTCTGTTCGACTCAATTTACGGGGCTTGTTATCTAAAGCA
AAGCAACTTTTTACAGATGTGGCAACTGGAGAAATGTCCAGGGAATTAGCTGATGACATAACAGCTATGGACACCTTAGTGACAGAGCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PPP3R1_ENST00000234310_chr2_68479257_-_TTC27_ENST00000317907_chr2_33007693_+_1273nt
TGCCTTGAGGTTGCGGGTCAGCGCGAGCCGCTGCAGTGAGTCCGTCACGGCTCCGGCGCGAGCGCGAGGCTGCAGCCCCCGAGTTTCCCG
GCCGTCTTCGCCCCCTCTCCCCCTCCTTTCTTCTTCTCTGCCTCTCCTGCCTCTCGCCGCTGCTCCTCCCGCGCTCTCCGGCTCTGAATC
TCGACCTTAATTTATTTCCCCCTACCCTGCCCGCTCCCTCGCGTGCCCAATCGCCCGGCCGGCGCGGGCCCCGCGGCGCCGCCTCCCCTC
CCCCACGCGCGCCCCCTCCCCGCCGGCGACCCGAGGGCCGCAGCTGGGCCGCCGCCGCCGTTTCCTGCGAGCCAGCCTGAGCGCAACACT
TCTCCGAGCCAGCGAGCCAGCGAGCCGCCGACCCGCCGAGCAAAATGAATGCTGAAGCTTGGAACAATTTGTCAACTTCCTATATCCGAT
TAAAACAAAAAGTAAAAGCTTTTAGAACTTTACAAGAAGCTCTCAAGTGTAACTATGAACACTGGCAGATTTGGGAAAACTACATCCTCA
CCAGCACTGACGTTGGGGAATTTTCAGAAGCCATTAAAGCTTATCACCGGCTCTTGGACTTACGTGACAAATACAAAGATGTTCAGGTCC
TTAAAATTCTAGTCAGGGCAGTGATTGATGGGATGACTGATCGAAGTGGAGATGTTGCAACTGGCCTCAAAGGAAAGCTGCAGGAGTTAT
TTGGCAGAGTGACTTCAAGAGTGACAAATGATGGAGAAATCTGGAGGCTGTATGCCCACGTATATGGAAATGGGCAGAGTGAAAAGCCTG
ATGAAAATGAAAAGGCATTCCAGTGCCTCTCAAAGGCATACAAGTGTGACACCCAGTCCAATTGTTGGGAGAAAGATATTACATCATTTA
AGGAAGTTGTTCAAAGAGCCTTAGGACTTGCACATGTGGCCATAAAATGCAGTAAAAACAAATCCAGTTCCCAAGAAGCTGTACAAATGC
TTTCTTCTGTTCGACTCAATTTACGGGGCTTGTTATCTAAAGCAAAGCAACTTTTTACAGATGTGGCAACTGGAGAAATGTCCAGGGAAT
TAGCTGATGACATAACAGCTATGGACACCTTAGTGACAGAGCTCCAAGACCTAAGCAACCAGTTTCGAAATCAGTATTGATTCTGCTGGA
AGCAGATTCTGGAAAAGGTGCTTTCACCTGCTGGTAAAAGATACATCTGTATATCTGAAATGCAAGATATTGATTTTTAAAATAAATTTG


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FusionGenePPI for PPP3R1_TTC27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP3R1PPIA, CABP2, CABP5, CABP1, ELAVL1, PSMA7, PDE4D, TRAF3, PPP3CA, IQCB1, NAP1L2, TP53, FAM122A, FCGR2A, PDHB, RCAN3, PPP3CC, RCAN2, MYH7, TINF2, PPP3CB, RCAN1, DEFA1, TMEM200A, KLRG2, NFATC1, DGCR14, SMPD3, CDR2, ARHGAP22, IGFBP6, CRTC2, SRBD1, DGUOK, NUFIP1, TRIM25TTC27PHLDA3, PTP4A3, MYC, TXLNA, NPM1, HDAC11, EGFR, FBXO6, C10orf76, CD2AP, GFPT1, MAPK3, NMD3, PPP2R5D, SKIV2L2, ASNS, CSTF1, CSTF2, DHX15, UFD1L, NTRK1, KRAS, FBXL12, FAF2, TTC27, EFTUD2, SNRNP200, PRPF8, CCT5, CCT6A, CCT4, CCT7, CCT2, AAR2, TCP1, CCT3, NCDN, ECD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP3R1_TTC27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP3R1_TTC27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP3R1C0036341Schizophrenia1PSYGENET
HgenePPP3R1C0149721Left Ventricular Hypertrophy1CTD_human
HgenePPP3R1C0151744Myocardial Ischemia1CTD_human