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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28482

FusionGeneSummary for PPP3CB_VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP3CB_VMP1
Fusion gene ID: 28482
HgeneTgene
Gene symbol

PPP3CB

VMP1

Gene ID

5532

81671

Gene nameprotein phosphatase 3 catalytic subunit betavacuole membrane protein 1
SynonymsCALNA2|CALNB|CNA2|PP2BbetaEPG3|TANGO5|TMEM49
Cytomap

10q22.2

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2B catalytic subunit beta isoformCAM-PRP catalytic subunitCNA betacalcineurin A betacalcineurin A2calmodulin-dependent calcineurin A subunit beta isoformprotein phosphatase 2B, catalytic subunit, beta isoformprovacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2018052320180523
UniProtAcc

P16298

Q96GC9

Ensembl transtripts involved in fusion geneENST00000360663, ENST00000394828, 
ENST00000394829, ENST00000342558, 
ENST00000545874, ENST00000394822, 
ENST00000544628, ENST00000495897, 
ENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
Fusion gene scores* DoF score5 X 4 X 4=8024 X 11 X 12=3168
# samples 527
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/3168*10)=-3.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP3CB [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3CB

GO:0006470

protein dephosphorylation

19154138|26794871

HgenePPP3CB

GO:0033173

calcineurin-NFAT signaling cascade

19154138|22688515

HgenePPP3CB

GO:0035690

cellular response to drug

11005320

HgenePPP3CB

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A1EB-01APPP3CBchr10

75227311

-VMP1chr17

57808782

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000360663ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000360663ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000360663ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000360663ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000360663ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-intronENST00000360663ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394828ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394828ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394828ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394828ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394828ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-intronENST00000394828ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394829ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394829ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394829ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394829ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394829ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-intronENST00000394829ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000342558ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000342558ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000342558ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000342558ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000342558ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-intronENST00000342558ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000545874ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000545874ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000545874ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000545874ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000545874ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-intronENST00000545874ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394822ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394822ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394822ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394822ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-5UTRENST00000394822ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
5CDS-intronENST00000394822ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000544628ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000544628ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000544628ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000544628ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000544628ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-intronENST00000544628ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000495897ENST00000262291PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000495897ENST00000537567PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000495897ENST00000539763PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000495897ENST00000536180PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-5UTRENST00000495897ENST00000545362PPP3CBchr10

75227311

-VMP1chr17

57808782

+
intron-intronENST00000495897ENST00000588617PPP3CBchr10

75227311

-VMP1chr17

57808782

+

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FusionProtFeatures for PPP3CB_VMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP3CB

P16298

VMP1

Q96GC9

Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals (PubMed:19154138,PubMed:26794871). Dephosphorylates and activates transcriptionfactor NFATC1 (PubMed:19154138). Dephosphorylates and inactivatestranscription factor ELK1 (PubMed:19154138). DephosphorylatesDARPP32 (PubMed:19154138). {ECO:0000269|PubMed:19154138,ECO:0000269|PubMed:26794871}. Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP3CB_VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP3CB_VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP3CBJUN, MLH1, IRAK1, IRF2, ELAVL1, PDE4D, ATG7, SRSF5, VPS25, VPS36, WDR12, WDR92, MARCH7, CEP76, TUBGCP3, RASSF2, PDHB, RCAN3, PPP3CC, RCAN2, PPP1R13B, PPP1R3A, HSPA9, RAD51, COX5A, RSRC1, PHF5A, RBM17, AHNAK, C6orf211, CALM2, GSK3A, LBH, PI4KA, PPP3R1, RCAN1, ZYX, TMEM200A, DEFA1, KLRG2, CDR2, CRTC2, LMTK2, AATK, EGFR, ROR2, PTK7, TRIM16VMP1HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP3CB_VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP3CB_VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP3CBC0019202Hepatolenticular Degeneration1CTD_human