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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28460

FusionGeneSummary for PPP2R5E_C14orf39

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R5E_C14orf39
Fusion gene ID: 28460
HgeneTgene
Gene symbol

PPP2R5E

C14orf39

Gene ID

5529

317761

Gene nameprotein phosphatase 2 regulatory subunit B'epsilonchromosome 14 open reading frame 39
SynonymsB56E|B56epsilonSix6os1
Cytomap

14q23.2

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPP2A, B subunit, B' epsilonPP2A, B subunit, B56 epsilonPP2A, B subunit, PR61 epsilonPP2A, B subunit, R5 epsilonepsilon isoform of regulatory subunit B56, protein phosphaprotein SIX6OS1six6 opposite strand transcript 1
Modification date2018052320180331
UniProtAcc

Q16537

Ensembl transtripts involved in fusion geneENST00000337537, ENST00000555899, 
ENST00000422769, ENST00000553266, 
ENST00000321731, 
Fusion gene scores* DoF score7 X 5 X 5=1753 X 4 X 3=36
# samples 73
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R5E [Title/Abstract] AND C14orf39 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-CC-5261-01APPP2R5Echr14

64006247

-C14orf39chr14

60966148

-
TCGALDLIHCTCGA-CC-5261-01APPP2R5Echr14

64006247

-C14orf39chr14

60935254

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337537ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60966148

-
5CDS-intronENST00000555899ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60966148

-
intron-intronENST00000422769ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60966148

-
5UTR-intronENST00000553266ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60966148

-
Frame-shitENST00000337537ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60935254

-
Frame-shitENST00000555899ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60935254

-
intron-3CDSENST00000422769ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60935254

-
5UTR-3CDSENST00000553266ENST00000321731PPP2R5Echr14

64006247

-C14orf39chr14

60935254

-

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FusionProtFeatures for PPP2R5E_C14orf39


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R5E

Q16537

C14orf39

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R5E_C14orf39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R5E_C14orf39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R5EPPP2CA, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, ELAVL1, NOD2, APP, CBX5, SMAD9, EGFR, AARS, TRMT10A, TERF2IP, SAE1, TPD52L2, ZDHHC17, CLOCK, CRY1, CSNK1E, CSNK2B, DEC1, BHLHE41, FBXW11, RORC, CRY2, PPP2R5E, PPP1CA, VTI1B, MOS, DNASE2B, FAM43A, WNT3A, DCLRE1C, CDK17, CCNG1, API5, IK, PPP2R5C, MARK2, SAMHD1, CDC20, NANOG, ZNF785, PRR14, ZFPL1, DCAF11, CRIP1, KLF15, GJB7, ZNF517, LPAR4, VSIG1, TMEM206, C1QL4, CCNG2, RPS27, C19orf57, TRIM25C14orf39


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R5E_C14orf39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R5E_C14orf39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R5EC1257806Chromosomal Instability1CTD_human
HgenePPP2R5EC1449861Micronuclei, Chromosome-Defective1CTD_human