|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28454 |
FusionGeneSummary for PPP2R5C_FOXN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R5C_FOXN3 | Fusion gene ID: 28454 | Hgene | Tgene | Gene symbol | PPP2R5C | FOXN3 | Gene ID | 5527 | 1112 |
| Gene name | protein phosphatase 2 regulatory subunit B'gamma | forkhead box N3 | |
| Synonyms | B56G|B56gamma|PR61G | C14orf116|CHES1|PRO1635 | |
| Cytomap | 14q32.31 | 14q31.3-q32.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat | forkhead box protein N3checkpoint suppressor 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13362 | O00409 | |
| Ensembl transtripts involved in fusion gene | ENST00000422945, ENST00000556068, ENST00000554442, ENST00000328724, ENST00000350249, ENST00000445439, ENST00000334743, ENST00000557095, ENST00000556260, ENST00000556946, ENST00000557714, | ENST00000345097, ENST00000261302, ENST00000557258, ENST00000555353, ENST00000555658, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 8 X 7 X 6=336 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP2R5C [Title/Abstract] AND FOXN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP2R5C | GO:0008285 | negative regulation of cell proliferation | 17245430 |
| Tgene | FOXN3 | GO:0045892 | negative regulation of transcription, DNA-templated | 16102918 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-IN-AB1X-01A | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000422945 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000422945 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000422945 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000422945 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000422945 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556068 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556068 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556068 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556068 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556068 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000554442 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000554442 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000554442 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000554442 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000554442 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000328724 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000328724 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000328724 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000328724 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000328724 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000350249 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000350249 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000350249 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000350249 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000350249 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000445439 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000445439 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000445439 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000445439 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000445439 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000334743 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000334743 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000334743 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000334743 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000334743 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000557095 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000557095 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000557095 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000557095 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| 5CDS-intron | ENST00000557095 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556260 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556260 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556260 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556260 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556260 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556946 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556946 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556946 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556946 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000556946 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000557714 | ENST00000345097 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000557714 | ENST00000261302 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000557714 | ENST00000557258 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000557714 | ENST00000555353 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
| intron-intron | ENST00000557714 | ENST00000555658 | PPP2R5C | chr14 | 102323222 | + | FOXN3 | chr14 | 89953015 | - |
Top |
FusionProtFeatures for PPP2R5C_FOXN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R5C | FOXN3 |
| The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The PP2A-PPP2R5C holoenzyme may specificallydephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may alsoregulate the ERK signaling pathway through ERK dephosphorylation.{ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. | Acts as a transcriptional repressor. May be involved inDNA damage-inducible cell cycle arrests (checkpoints).{ECO:0000269|PubMed:16102918}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PPP2R5C_FOXN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PPP2R5C_FOXN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP2R5C | CCNG2, PPP2CA, PPP2R5A, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, MBP, TBC1D3, APP, BRCA1, PAXIP1, IER3, MAPK1, SOX2, COL4A3BP, FAF1, JMJD6, PACSIN2, UGP2, PSMG3, SWAP70, EGFR, EP300, FAM43A, CCNG1, API5, LSM6, LSM7, PPP2R2A, POLD1, PPP2R5E, RQCD1, TP53, PRR14, PPP1CA, PPP1CB, PPP1CC, TRIM25 | FOXN3 | MEN1, ELAVL1, EXOSC8, SRPK2, CHSY3, CHSY1, FOXO3B, HRNR, KBTBD7, FOXR2, RFX2, RFX3, RFX1, ZBTB34, BTRC, FBXW11, DDB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPP2R5C_FOXN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PPP2R5C_FOXN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPP2R5C | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
| Hgene | PPP2R5C | C1257806 | Chromosomal Instability | 1 | CTD_human |
| Hgene | PPP2R5C | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|