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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28453

FusionGeneSummary for PPP2R5C_CCDC28B

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R5C_CCDC28B
Fusion gene ID: 28453
HgeneTgene
Gene symbol

PPP2R5C

CCDC28B

Gene ID

5527

79140

Gene nameprotein phosphatase 2 regulatory subunit B'gammacoiled-coil domain containing 28B
SynonymsB56G|B56gamma|PR61G-
Cytomap

14q32.31

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphatcoiled-coil domain-containing protein 28B
Modification date2018052320180523
UniProtAcc

Q13362

Q9BUN5

Ensembl transtripts involved in fusion geneENST00000422945, ENST00000556068, 
ENST00000554442, ENST00000328724, 
ENST00000350249, ENST00000445439, 
ENST00000334743, ENST00000557095, 
ENST00000556260, ENST00000556946, 
ENST00000557714, 		ENST00000373602, 
ENST00000421922, ENST00000483009, 
Fusion gene scores* DoF score5 X 4 X 5=1005 X 3 X 3=45
# samples 54
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R5C [Title/Abstract] AND CCDC28B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R5C

GO:0008285

negative regulation of cell proliferation

17245430


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-EP-A2KA-01APPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000422945ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000422945ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-3UTRENST00000422945ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000556068ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000556068ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-3UTRENST00000556068ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000554442ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000554442ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-3UTRENST00000554442ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000328724ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000328724ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-3UTRENST00000328724ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000350249ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000350249ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-3UTRENST00000350249ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000445439ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000445439ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-3UTRENST00000445439ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000334743ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000334743ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-3UTRENST00000334743ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000557095ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-5UTRENST00000557095ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
5CDS-3UTRENST00000557095ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000556260ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000556260ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-3UTRENST00000556260ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000556946ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000556946ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-3UTRENST00000556946ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000557714ENST00000373602PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-5UTRENST00000557714ENST00000421922PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+
intron-3UTRENST00000557714ENST00000483009PPP2R5Cchr14

102360897

+CCDC28Bchr1

32667514

+

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FusionProtFeatures for PPP2R5C_CCDC28B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R5C

Q13362

CCDC28B

Q9BUN5

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The PP2A-PPP2R5C holoenzyme may specificallydephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may alsoregulate the ERK signaling pathway through ERK dephosphorylation.{ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. Involved in ciliogenesis. Regulates cilia length throughits interaction with MAPKAP1/SIN1 but independently of mTORC2complex. Modulates mTORC2 complex assembly and function, possiblyenhances AKT1 phosphorylation. Does not seem to modulate assemblyand function of mTORC1 complex. {ECO:0000269|PubMed:23015189,ECO:0000269|PubMed:23727834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R5C_CCDC28B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R5C_CCDC28B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R5CCCNG2, PPP2CA, PPP2R5A, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, MBP, TBC1D3, APP, BRCA1, PAXIP1, IER3, MAPK1, SOX2, COL4A3BP, FAF1, JMJD6, PACSIN2, UGP2, PSMG3, SWAP70, EGFR, EP300, FAM43A, CCNG1, API5, LSM6, LSM7, PPP2R2A, POLD1, PPP2R5E, RQCD1, TP53, PRR14, PPP1CA, PPP1CB, PPP1CC, TRIM25CCDC28BAPP, ATRIP, OSGEP, LAGE3, PRAME, IFT81, HSPA1L, IFT74


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R5C_CCDC28B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R5C_CCDC28B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R5CC0023434Chronic Lymphocytic Leukemia1CTD_human
HgenePPP2R5CC1257806Chromosomal Instability1CTD_human
HgenePPP2R5CC1449861Micronuclei, Chromosome-Defective1CTD_human