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Fusion gene ID: 28448 |
FusionGeneSummary for PPP2R5A_CHRM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R5A_CHRM3 | Fusion gene ID: 28448 | Hgene | Tgene | Gene symbol | PPP2R5A | CHRM3 | Gene ID | 5525 | 1131 |
| Gene name | protein phosphatase 2 regulatory subunit B'alpha | cholinergic receptor muscarinic 3 | |
| Synonyms | B56A|B56alpha|PR61A | EGBRS|HM3|PBS | |
| Cytomap | 1q32.3 | 1q43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B su | muscarinic acetylcholine receptor M3acetylcholine receptor, muscarinic 3m3 muscarinic receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15172 | P20309 | |
| Ensembl transtripts involved in fusion gene | ENST00000261461, ENST00000537030, ENST00000498129, | ENST00000468573, ENST00000255380, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 12 X 12 X 4=576 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(13/576*10)=-2.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP2R5A [Title/Abstract] AND CHRM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP2R5A | GO:0006470 | protein dephosphorylation | 24157919 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-5518-01A | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000261461 | ENST00000468573 | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
| 5CDS-intron | ENST00000261461 | ENST00000255380 | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
| intron-3UTR | ENST00000537030 | ENST00000468573 | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
| intron-intron | ENST00000537030 | ENST00000255380 | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
| intron-3UTR | ENST00000498129 | ENST00000468573 | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
| intron-intron | ENST00000498129 | ENST00000255380 | PPP2R5A | chr1 | 212459633 | + | CHRM3 | chr1 | 239656009 | + |
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FusionProtFeatures for PPP2R5A_CHRM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R5A | CHRM3 |
| The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. | The muscarinic acetylcholine receptor mediates variouscellular responses, including inhibition of adenylate cyclase,breakdown of phosphoinositides and modulation of potassiumchannels through the action of G proteins. Primary transducingeffect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP2R5A_CHRM3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP2R5A_CHRM3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP2R5A | APC, BCL2, PPP2R5C, EIF2AK2, PPP2CA, PPP2R1A, PPP2R1B, AXIN1, CTLA4, MYC, CHEK2, NEK1, CBX5, ESPL1, PTTG1, PPP2R2D, DAPK1, PPP2CB, MOS, FAM43A, WNT3A, PPP2R5D, CDC20, CDC27, BUB1B, UBE2S, PRR14, TRIM25 | CHRM3 | ARF1, ARF6, CSNK1A1, SET, ATP1A4, TUBA3C, CCRN4L, PLD2, SLC4A7, FARP2, HEATR3, CAV1, YIPF4, GTPBP2, PTRH2, DCP2, IPO9, GBF1, USP46, GPN3, IPO13, DYM, STARD3, HOOK2, EXOC2, TUBA4A, PI4KA, ATL2, FASTKD1, TTI1, DNAJA3, FTSJ1, CAND2, TUBB3, C1orf112, LRP10, PIK3CB, JPH1, PPP6R1, LTN1, TUBB8, PIGX, PBXIP1, C10orf35, IPO7, ARL10, TELO2, NARS2, FLT4, STX18 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP2R5A_CHRM3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CHRM3 | P20309 | DB00185 | Cevimeline | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00202 | Succinylcholine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00246 | Ziprasidone | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00280 | Disopyramide | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00321 | Amitriptyline | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00332 | Ipratropium bromide | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00340 | Metixene | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00363 | Clozapine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00376 | Trihexyphenidyl | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00383 | Oxyphencyclimine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00387 | Procyclidine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00408 | Loxapine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00411 | Carbachol | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00424 | Hyoscyamine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00434 | Cyproheptadine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00458 | Imipramine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00540 | Nortriptyline | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00725 | Homatropine Methylbromide | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00777 | Propiomazine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00835 | Brompheniramine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01019 | Bethanechol | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01224 | Quetiapine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01226 | Mivacurium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01337 | Pancuronium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01338 | Pipecuronium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01409 | Tiotropium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB01591 | Solifenacin | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB03128 | Acetylcholine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB04843 | Mepenzolate | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB06702 | Fesoterodine | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB06787 | Hexocyclium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB08897 | Aclidinium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB09076 | Umeclidinium | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB09167 | Dosulepin | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB09357 | Dexpanthenol | Muscarinic acetylcholine receptor M3 | small molecule | approved |
| Tgene | CHRM3 | P20309 | DB00193 | Tramadol | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00334 | Olanzapine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00496 | Darifenacin | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00622 | Nicardipine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00715 | Paroxetine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00747 | Scopolamine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00809 | Tropicamide | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00934 | Maprotiline | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01036 | Tolterodine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01062 | Oxybutynin | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01069 | Promethazine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01085 | Pilocarpine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01142 | Doxepin | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01151 | Desipramine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01238 | Aripiprazole | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB01403 | Methotrimeprazine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational |
| Tgene | CHRM3 | P20309 | DB00477 | Chlorpromazine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational|vet_approved |
| Tgene | CHRM3 | P20309 | DB00986 | Glycopyrronium | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational|vet_approved |
| Tgene | CHRM3 | P20309 | DB09300 | Butylscopolamine | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational|vet_approved |
| Tgene | CHRM3 | P20309 | DB01239 | Chlorprothixene | Muscarinic acetylcholine receptor M3 | small molecule | approved|investigational|withdrawn |
| Tgene | CHRM3 | P20309 | DB00420 | Promazine | Muscarinic acetylcholine receptor M3 | small molecule | approved|vet_approved |
| Tgene | CHRM3 | P20309 | DB00572 | Atropine | Muscarinic acetylcholine receptor M3 | small molecule | approved|vet_approved |
| Tgene | CHRM3 | P20309 | DB00599 | Thiopental | Muscarinic acetylcholine receptor M3 | small molecule | approved|vet_approved |
| Tgene | CHRM3 | P20309 | DB01625 | Isopropamide | Muscarinic acetylcholine receptor M3 | small molecule | approved|vet_approved |
| Tgene | CHRM3 | P20309 | DB00342 | Terfenadine | Muscarinic acetylcholine receptor M3 | small molecule | approved|withdrawn |
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RelatedDiseases for PPP2R5A_CHRM3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPP2R5A | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
| Tgene | CHRM3 | C0003962 | Ascites | 1 | CTD_human |
| Tgene | CHRM3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | CHRM3 | C0005686 | Urinary Bladder Diseases | 1 | CTD_human |
| Tgene | CHRM3 | C0010417 | Cryptorchidism | 1 | CTD_human;HPO |
| Tgene | CHRM3 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Tgene | CHRM3 | C0033770 | Prune Belly Syndrome | 1 | CTD_human;HPO;ORPHANET |
| Tgene | CHRM3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | CHRM3 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | CHRM3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | CHRM3 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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