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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 2844

FusionGeneSummary for ARRB1_UVRAG

check button Fusion gene summary
Fusion gene informationFusion gene name: ARRB1_UVRAG
Fusion gene ID: 2844
HgeneTgene
Gene symbol

ARRB1

UVRAG

Gene ID

408

7405

Gene namearrestin beta 1UV radiation resistance associated
SynonymsARB1|ARR1DHTX|VPS38|p63
Cytomap

11q13.4

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionbeta-arrestin-1arrestin 2non-visual arrestin-2UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
Modification date2018052220180523
UniProtAcc

P49407

Q9P2Y5

Ensembl transtripts involved in fusion geneENST00000420843, ENST00000393505, 
ENST00000360025, 
ENST00000356136, 
ENST00000528420, ENST00000533454, 
ENST00000531818, ENST00000532130, 
ENST00000539288, ENST00000525872, 
ENST00000538870, 
Fusion gene scores* DoF score15 X 6 X 6=54024 X 13 X 11=3432
# samples 2125
** MAII scorelog2(21/540*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(25/3432*10)=-3.77904955283746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARRB1 [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARRB1

GO:0031397

negative regulation of protein ubiquitination

16378096

HgeneARRB1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16378096

HgeneARRB1

GO:0032715

negative regulation of interleukin-6 production

16378096

HgeneARRB1

GO:0032717

negative regulation of interleukin-8 production

16378096

HgeneARRB1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10644702

TgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

TgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A1-A0SM-01AARRB1chr11

75062632

-UVRAGchr11

75715049

+
TCGALDLUSCTCGA-33-4587-01AARRB1chr11

75062632

-UVRAGchr11

75599873

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000420843ENST00000356136ARRB1chr11

75062632

-UVRAGchr11

75715049

+
Frame-shiftENST00000420843ENST00000528420ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000420843ENST00000533454ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000420843ENST00000531818ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000420843ENST00000532130ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000420843ENST00000539288ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-intronENST00000420843ENST00000525872ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-intronENST00000420843ENST00000538870ARRB1chr11

75062632

-UVRAGchr11

75715049

+
Frame-shiftENST00000393505ENST00000356136ARRB1chr11

75062632

-UVRAGchr11

75715049

+
Frame-shiftENST00000393505ENST00000528420ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000393505ENST00000533454ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000393505ENST00000531818ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000393505ENST00000532130ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000393505ENST00000539288ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-intronENST00000393505ENST00000525872ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-intronENST00000393505ENST00000538870ARRB1chr11

75062632

-UVRAGchr11

75715049

+
Frame-shiftENST00000360025ENST00000356136ARRB1chr11

75062632

-UVRAGchr11

75715049

+
Frame-shiftENST00000360025ENST00000528420ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000360025ENST00000533454ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000360025ENST00000531818ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000360025ENST00000532130ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-5UTRENST00000360025ENST00000539288ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-intronENST00000360025ENST00000525872ARRB1chr11

75062632

-UVRAGchr11

75715049

+
5CDS-intronENST00000360025ENST00000538870ARRB1chr11

75062632

-UVRAGchr11

75715049

+
In-frameENST00000420843ENST00000356136ARRB1chr11

75062632

-UVRAGchr11

75599873

+
In-frameENST00000420843ENST00000528420ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000420843ENST00000533454ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000420843ENST00000531818ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000420843ENST00000532130ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000420843ENST00000539288ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000420843ENST00000525872ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000420843ENST00000538870ARRB1chr11

75062632

-UVRAGchr11

75599873

+
In-frameENST00000393505ENST00000356136ARRB1chr11

75062632

-UVRAGchr11

75599873

+
In-frameENST00000393505ENST00000528420ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000393505ENST00000533454ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000393505ENST00000531818ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000393505ENST00000532130ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000393505ENST00000539288ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000393505ENST00000525872ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000393505ENST00000538870ARRB1chr11

75062632

-UVRAGchr11

75599873

+
In-frameENST00000360025ENST00000356136ARRB1chr11

75062632

-UVRAGchr11

75599873

+
In-frameENST00000360025ENST00000528420ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000360025ENST00000533454ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000360025ENST00000531818ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000360025ENST00000532130ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000360025ENST00000539288ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000360025ENST00000525872ARRB1chr11

75062632

-UVRAGchr11

75599873

+
5CDS-intronENST00000360025ENST00000538870ARRB1chr11

75062632

-UVRAGchr11

75599873

+

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FusionProtFeatures for ARRB1_UVRAG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARRB1

P49407

UVRAG

Q9P2Y5

Functions in regulating agonist-mediated G-proteincoupled receptor (GPCR) signaling by mediating both receptordesensitization and resensitization processes. During homologousdesensitization, beta-arrestins bind to the GPRK-phosphorylatedreceptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptordeterminants exposed only in the active receptor conformation. Thebeta-arrestins target many receptors for internalization by actingas endocytic adapters (CLASPs, clathrin-associated sortingproteins) and recruiting the GPRCs to the adapter protein 2complex 2 (AP-2) in clathrin-coated pits (CCPs). However, theextent of beta-arrestin involvement appears to vary significantlydepending on the receptor, agonist and cell type. Internalizedarrestin-receptor complexes traffic to intracellular endosomes,where they remain uncoupled from G-proteins. Two different modesof arrestin-mediated internalization occur. Class A receptors,like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapidrecycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR andTACR1 internalize as a complex with arrestin and traffic with itto endosomal vesicles, presumably as desensitized receptors, forextended periods of time. Receptor resensitization then requiresthat receptor-bound arrestin is removed so that the receptor canbe dephosphorylated and returned to the plasma membrane. Involvedin internalization of P2RY4 and UTP-stimulated internalization ofP2RY2. Involved in phosphorylation-dependent internalization ofOPRD1 ands subsequent recycling. Involved in the degradation ofcAMP by recruiting cAMP phosphodiesterases to ligand-activatedreceptors. Beta-arrestins function as multivalent adapter proteinsthat can switch the GPCR from a G-protein signaling mode thattransmits short-lived signals from the plasma membrane via smallmolecule second messengers and ion channels to a beta-arrestinsignaling mode that transmits a distinct set of signals that areinitiated as the receptor internalizes and transits theintracellular compartment. Acts as signaling scaffold for MAPKpathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus andconfined to cytoplasmic locations such as endocytic vesicles, alsocalled beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependentregulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs thebeta-arrestin-mediated signaling relies on either ARRB1 or ARRB2and is inhibited by the other respective beta-arrestin form(reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- andAVPR2-mediated activation (reciprocal regulation). Is required forSP-stimulated endocytosis of NK1R and recruits c-Src/SRC tointernalized NK1R resulting in ERK1/2 activation, which isrequired for the antiapoptotic effects of SP. Is involved inproteinase-activated F2RL1-mediated ERK activity. Acts assignaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulatedAKT1 signaling leading to increased protection from apoptosis.Involved in activation of the p38 MAPK signaling pathway and inactin bundle formation. Involved in F2RL1-mediated cytoskeletalrearrangement and chemotaxis. Involved in AGTR1-mediated stressfiber formation by acting together with GNAQ to activate RHOA.Appears to function as signaling scaffold involved in regulationof MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved inattenuation of NF-kappa-B-dependent transcription in response toGPCR or cytokine stimulation by interacting with and stabilizingCHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1Band FOS promoter regions and recruiting EP300 resulting inacetylation of histone H4. Involved in regulation of LEF1transcriptional activity via interaction with DVL1 and/or DVL2Also involved in regulation of receptors other than GPCRs.Involved in Toll-like receptor and IL-1 receptor signaling throughthe interaction with TRAF6 which prevents TRAF6 autoubiquitinationand oligomerization required for activation of NF-kappa-B and JUN.Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6)(By similarity). Involved in IL8-mediated granule release inneutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin(CFL1) and for the up-regulation of ACKR2 from endosomalcompartment to cell membrane, increasing its efficiency inchemokine uptake and degradation. Involved in the internalizationof the atypical chemokine receptor ACKR3. Negatively regulates theNOTCH signaling pathway by mediating the ubiquitination anddegradation of NOTCH1 by ITCH. Participates to the recruitment ofthe ubiquitin-protein ligase to the receptor (PubMed:23886940).{ECO:0000250, ECO:0000269|PubMed:12464600,ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15475570,ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:15671180,ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840,ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096,ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16709866,ECO:0000269|PubMed:18337459, ECO:0000269|PubMed:18419762,ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177,ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23341447,ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:23886940}. Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUVRAGchr11:75062632chr11:75599873ENST00000356136+315224_305144700Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARRB1chr11:75062632chr11:75599873ENST00000360025-115385_3956411MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
HgeneARRB1chr11:75062632chr11:75599873ENST00000420843-116385_3956419MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
TgeneUVRAGchr11:75062632chr11:75599873ENST00000356136+31544_128144700DomainNote=C2


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FusionGeneSequence for ARRB1_UVRAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ARRB1_ENST00000420843_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_562aa
MGDKGTRFMPETKMKXFLGXMMDTMVLHLNIRVIQMLRRLFFCRWIRTVFAILTMSSLCYGFIEPSVQLNRLRXLFRKLERKLKKNXDSH
LQAMNXKKKVNACSXKFWCFRMNWNGRRKLWDGRWHYCISNKLHYKTKEVHFQLSTSNFNSRRNPXMSXGRSALQKENSSXRLMLSXQFV
AGSYSLSFPTFTLLIXMNIRITLYAVSSCLILRTSKQKMMEALLLPLVILHIWSPXFPFSYKCPSDILXFIRGLDQQSKTISMTNXRKRR
ESFHCIQKEGRSCSLIMVSIFXTKIXHSXDINMDXGLQTCGKPFPTXKTSWSMDXWSGVTDITPPVQSLFLRDKAPYLGVQMXASLGGSL
HQTKDIENGPALRMRDFSTKPLLPVTTQHXPSLXPPSPPWERPRERXHLYPPPWIPPWTSPKKTRKKERIXLAAXTEATRMCTLAKNKEK
PSPGTGPQSMALSYPASRPGPPVSSFQASSTQSQKLSSAVLWSKQKKSSGWKPQVSPQVISXKHLTASQWTVLWQXSVTNKFWENLKSSP

>In-frame_ARRB1_ENST00000420843_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_562aa
MGDKGTRFMPETKMKXFLGXMMDTMVLHLNIRVIQMLRRLFFCRWIRTVFAILTMSSLCYGFIEPSVQLNRLRXLFRKLERKLKKNXDSH
LQAMNXKKKVNACSXKFWCFRMNWNGRRKLWDGRWHYCISNKLHYKTKEVHFQLSTSNFNSRRNPXMSXGRSALQKENSSXRLMLSXQFV
AGSYSLSFPTFTLLIXMNIRITLYAVSSCLILRTSKQKMMEALLLPLVILHIWSPXFPFSYKCPSDILXFIRGLDQQSKTISMTNXRKRR
ESFHCIQKEGRSCSLIMVSIFXTKIXHSXDINMDXGLQTCGKPFPTXKTSWSMDXWSGVTDITPPVQSLFLRDKAPYLGVQMXASLGGSL
HQTKDIENGPALRMRDFSTKPLLPVTTQHXPSLXPPSPPWERPRERXHLYPPPWIPPWTSPKKTRKKERIXLAAXTEATRMCTLAKNKEK
PSPGTGPQSMALSYPASRPGPPVSSFQASSTQSQKLSSAVLWSKQKKSSGWKPQVSPQVISXKHLTASQWTVLWQXSVTNKFWENLKSSP

>In-frame_ARRB1_ENST00000393505_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_562aa
MGDKGTRFMPETKMKXFLGXMMDTMVLHLNIRVIQMLRRLFFCRWIRTVFAILTMSSLCYGFIEPSVQLNRLRXLFRKLERKLKKNXDSH
LQAMNXKKKVNACSXKFWCFRMNWNGRRKLWDGRWHYCISNKLHYKTKEVHFQLSTSNFNSRRNPXMSXGRSALQKENSSXRLMLSXQFV
AGSYSLSFPTFTLLIXMNIRITLYAVSSCLILRTSKQKMMEALLLPLVILHIWSPXFPFSYKCPSDILXFIRGLDQQSKTISMTNXRKRR
ESFHCIQKEGRSCSLIMVSIFXTKIXHSXDINMDXGLQTCGKPFPTXKTSWSMDXWSGVTDITPPVQSLFLRDKAPYLGVQMXASLGGSL
HQTKDIENGPALRMRDFSTKPLLPVTTQHXPSLXPPSPPWERPRERXHLYPPPWIPPWTSPKKTRKKERIXLAAXTEATRMCTLAKNKEK
PSPGTGPQSMALSYPASRPGPPVSSFQASSTQSQKLSSAVLWSKQKKSSGWKPQVSPQVISXKHLTASQWTVLWQXSVTNKFWENLKSSP

>In-frame_ARRB1_ENST00000393505_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_562aa
MGDKGTRFMPETKMKXFLGXMMDTMVLHLNIRVIQMLRRLFFCRWIRTVFAILTMSSLCYGFIEPSVQLNRLRXLFRKLERKLKKNXDSH
LQAMNXKKKVNACSXKFWCFRMNWNGRRKLWDGRWHYCISNKLHYKTKEVHFQLSTSNFNSRRNPXMSXGRSALQKENSSXRLMLSXQFV
AGSYSLSFPTFTLLIXMNIRITLYAVSSCLILRTSKQKMMEALLLPLVILHIWSPXFPFSYKCPSDILXFIRGLDQQSKTISMTNXRKRR
ESFHCIQKEGRSCSLIMVSIFXTKIXHSXDINMDXGLQTCGKPFPTXKTSWSMDXWSGVTDITPPVQSLFLRDKAPYLGVQMXASLGGSL
HQTKDIENGPALRMRDFSTKPLLPVTTQHXPSLXPPSPPWERPRERXHLYPPPWIPPWTSPKKTRKKERIXLAAXTEATRMCTLAKNKEK
PSPGTGPQSMALSYPASRPGPPVSSFQASSTQSQKLSSAVLWSKQKKSSGWKPQVSPQVISXKHLTASQWTVLWQXSVTNKFWENLKSSP

>In-frame_ARRB1_ENST00000360025_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_562aa
MGDKGTRFMPETKMKXFLGXMMDTMVLHLNIRVIQMLRRLFFCRWIRTVFAILTMSSLCYGFIEPSVQLNRLRXLFRKLERKLKKNXDSH
LQAMNXKKKVNACSXKFWCFRMNWNGRRKLWDGRWHYCISNKLHYKTKEVHFQLSTSNFNSRRNPXMSXGRSALQKENSSXRLMLSXQFV
AGSYSLSFPTFTLLIXMNIRITLYAVSSCLILRTSKQKMMEALLLPLVILHIWSPXFPFSYKCPSDILXFIRGLDQQSKTISMTNXRKRR
ESFHCIQKEGRSCSLIMVSIFXTKIXHSXDINMDXGLQTCGKPFPTXKTSWSMDXWSGVTDITPPVQSLFLRDKAPYLGVQMXASLGGSL
HQTKDIENGPALRMRDFSTKPLLPVTTQHXPSLXPPSPPWERPRERXHLYPPPWIPPWTSPKKTRKKERIXLAAXTEATRMCTLAKNKEK
PSPGTGPQSMALSYPASRPGPPVSSFQASSTQSQKLSSAVLWSKQKKSSGWKPQVSPQVISXKHLTASQWTVLWQXSVTNKFWENLKSSP

>In-frame_ARRB1_ENST00000360025_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_562aa
MGDKGTRFMPETKMKXFLGXMMDTMVLHLNIRVIQMLRRLFFCRWIRTVFAILTMSSLCYGFIEPSVQLNRLRXLFRKLERKLKKNXDSH
LQAMNXKKKVNACSXKFWCFRMNWNGRRKLWDGRWHYCISNKLHYKTKEVHFQLSTSNFNSRRNPXMSXGRSALQKENSSXRLMLSXQFV
AGSYSLSFPTFTLLIXMNIRITLYAVSSCLILRTSKQKMMEALLLPLVILHIWSPXFPFSYKCPSDILXFIRGLDQQSKTISMTNXRKRR
ESFHCIQKEGRSCSLIMVSIFXTKIXHSXDINMDXGLQTCGKPFPTXKTSWSMDXWSGVTDITPPVQSLFLRDKAPYLGVQMXASLGGSL
HQTKDIENGPALRMRDFSTKPLLPVTTQHXPSLXPPSPPWERPRERXHLYPPPWIPPWTSPKKTRKKERIXLAAXTEATRMCTLAKNKEK
PSPGTGPQSMALSYPASRPGPPVSSFQASSTQSQKLSSAVLWSKQKKSSGWKPQVSPQVISXKHLTASQWTVLWQXSVTNKFWENLKSSP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ARRB1_ENST00000420843_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_1688nt
ATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAAC
ATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTAC
GGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACAT
CTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTT
TGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAAC
TCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTT
GCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTA
ATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCC
TACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGA
GAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGAT
ATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACA
GACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTT
CACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAG
CCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCT
CCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAG
CCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCC
ACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATC
AGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCC

>In-frame_ARRB1_ENST00000420843_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_1688nt
ATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAAC
ATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTAC
GGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACAT
CTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTT
TGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAAC
TCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTT
GCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTA
ATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCC
TACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGA
GAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGAT
ATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACA
GACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTT
CACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAG
CCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCT
CCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAG
CCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCC
ACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATC
AGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCC

>In-frame_ARRB1_ENST00000393505_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_1688nt
ATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAAC
ATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTAC
GGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACAT
CTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTT
TGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAAC
TCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTT
GCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTA
ATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCC
TACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGA
GAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGAT
ATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACA
GACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTT
CACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAG
CCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCT
CCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAG
CCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCC
ACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATC
AGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCC

>In-frame_ARRB1_ENST00000393505_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_1688nt
ATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAAC
ATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTAC
GGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACAT
CTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTT
TGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAAC
TCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTT
GCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTA
ATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCC
TACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGA
GAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGAT
ATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACA
GACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTT
CACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAG
CCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCT
CCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAG
CCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCC
ACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATC
AGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCC

>In-frame_ARRB1_ENST00000360025_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_1688nt
ATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAAC
ATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTAC
GGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACAT
CTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTT
TGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAAC
TCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTT
GCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTA
ATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCC
TACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGA
GAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGAT
ATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACA
GACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTT
CACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAG
CCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCT
CCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAG
CCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCC
ACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATC
AGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCC

>In-frame_ARRB1_ENST00000360025_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_1688nt
ATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAAC
ATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTAC
GGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACAT
CTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTT
TGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAAC
TCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTT
GCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTA
ATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCC
TACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGA
GAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGAT
ATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACA
GACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTT
CACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAG
CCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCT
CCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAG
CCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCC
ACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATC
AGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ARRB1_ENST00000420843_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_3568nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCC
ATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTC
TTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAG
ACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAA
GAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAA
ACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGAC
AATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAA
GTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTC
CTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGA
AAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACA
GCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAG
GTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGG
GATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTC
AGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTT
GGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACA
AGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGG
CGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTC
AGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGA
GTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAA
CAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAAT
GGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTC
AAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTG
TCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAA
GCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCAT
CTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACCT
TTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTAG
CTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTGC
TCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGT
GGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTTA
TTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGA
TAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTTG
TCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAA
ATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGACCTGATTTTTTTTTACCAGCTTGGAAATTCC
TCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCATGTCTATCTAAGCGGAGGCTGTTGACTTCATT
CAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCACATTTGTCCTGCATAACAGCTTCACTCACAG
GCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGCTACATTGTTGTTTTCCATGTAGAGAACTCAC
AGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATCTGCAGAAGCCCATCTTCCTCCACATGAAGAA
GTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTTTGGAGTCAGTGTGGGTGGAGACAGCATCGTG

>In-frame_ARRB1_ENST00000420843_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_2167nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCC
ATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTC
TTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAG
ACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAA
GAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAA
ACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGAC
AATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAA
GTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTC
CTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGA
AAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACA
GCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAG
GTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGG
GATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTC
AGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTT
GGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACA
AGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGG
CGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTC
AGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGA
GTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAA
CAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAAT
GGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTC
AAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTG
TCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAA

>In-frame_ARRB1_ENST00000393505_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_3692nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAA
TTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATC
AGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTC
AGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAA
TTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAG
ACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAA
GAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGA
ATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCC
TTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAA
CAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATT
ATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACC
TGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCA
TATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGAC
TTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGA
TAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACG
GAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCG
AGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAG
AAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAG
AGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGC
GCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCC
TTTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCAT
TGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAA
GAGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAA
ATAATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATA
GGTTTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGT
CCCTCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACA
GGACATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCC
TTAATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCC
ATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGAC
AAAAATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGG
GGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTT
CATGAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGA
CATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACC
CGACCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGC
CATGTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCG
CCACATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTAT
AGCTACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGG
ATCTGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCA
TTTTGGAGTCAGTGTGGGTGGAGACAGCATCGTGGATATGCACGTGCTGCGGGGCCCTCCAGGGAAGTAACATTTACCAAAAAAAAAGAA

>In-frame_ARRB1_ENST00000393505_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_2291nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAA
TTTTTGGGCTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATC
AGAACTGTGTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTC
AGAAAATTGGAAAGGAAATTGAAGAAAAACTAAGACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAA
TTTTGGTGCTTCAGAATGAACTGGAACGGCAGAAGAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAG
ACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAAACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAA
GAGAACTCTTCTTGAAGACTAATGCTCAGTTGACAATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGA
ATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCC
TTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAA
CAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATT
ATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACC
TGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCA
TATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGAC
TTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGA
TAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACG
GAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCG
AGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAG
AAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAG
AGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGC
GCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCC
TTTGTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCAT
TGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAA
GAGCTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAA

>In-frame_ARRB1_ENST00000360025_chr11_75062632_-_UVRAG_ENST00000356136_chr11_75599873_+_3568nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCC
ATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTC
TTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAG
ACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAA
GAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAA
ACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGAC
AATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAA
GTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTC
CTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGA
AAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACA
GCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAG
GTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGG
GATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTC
AGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTT
GGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACA
AGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGG
CGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTC
AGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGA
GTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAA
CAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAAT
GGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTC
AAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTG
TCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAA
GCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGTTTCCGCCATGTACTGAAAGGTCTGTGGCCAT
CTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCCTCTTCCTGCCCCCGGGTACCACAGTCCACCT
TTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGACATCAGATTCACTGGTTCTGTAACCCAGTAG
CTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTAATGCGGCCCTCAGATTAGATGAAAAACTTGC
TCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATCTCATCCCCTGTGGGGGCCAAAGTTTTTATGT
GGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAAAATCCCTTGATGTAAATCCCATGTTAATTTA
TTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGTGTCTGGTAGGCAAACTGCAAGGCAGTTGAGA
TAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCATGAATATTAAATTATGTTTCGAAGTCCAGTTG
TCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACATTGCCTCAGGGTTGCAAACTCTTTAAAGGAAA
ATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGACCTGATTTTTTTTTACCAGCTTGGAAATTCC
TCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCATGTCTATCTAAGCGGAGGCTGTTGACTTCATT
CAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCACATTTGTCCTGCATAACAGCTTCACTCACAG
GCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGCTACATTGTTGTTTTCCATGTAGAGAACTCAC
AGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATCTGCAGAAGCCCATCTTCCTCCACATGAAGAA
GTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTTTGGAGTCAGTGTGGGTGGAGACAGCATCGTG

>In-frame_ARRB1_ENST00000360025_chr11_75062632_-_UVRAG_ENST00000528420_chr11_75599873_+_2167nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGGATACTATGGTGCTCC
ATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTCTTACGATGTCTTCTC
TTTGCTACGGCTTCATAGAGCCCAGTGTGCAATTAAACAGACTCAGGTAACTGTTCAGAAAATTGGAAAGGAAATTGAAGAAAAACTAAG
ACTCACATCTACAAGCAATGAACTGAAAAAAAAAAGTGAATGCCTGCAGTTAAAAATTTTGGTGCTTCAGAATGAACTGGAACGGCAGAA
GAAAGCTTTGGGACGGGAGGTGGCATTACTGCATAAGCAACAAATTGCATTACAAGACAAAGGAAGTGCATTTTCAGCTGAGCACCTCAA
ACTTCAACTCCAGAAGGAATCCCTAAATGAGCTGAGGAAGGAGTGCACTGCAAAAAGAGAACTCTTCTTGAAGACTAATGCTCAGTTGAC
AATTCGTTGCAGGCAGTTACTCTCTGAGCTTTCCTACATTTACCCTATTGATTTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAA
GTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTC
CTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGA
AAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACA
GCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAG
GTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGG
GATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTC
AGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTT
GGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACA
AGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGG
CGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTC
AGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGA
GTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCAGGAGTTCCGATAAGTGAAGTGAGCAGGTCAA
CAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTTGTGATAATGATGACACAAAATGAATATTAAT
GGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGTTATCAGTGGGCCAAAGTTAGATTTTGCTTTC
AAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAGCTTACAGCTCGAGTCACCTTTTAGCTATTTG
TCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATAATATAATGAACACACCCTTAGTTTCTCATAA


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FusionGenePPI for ARRB1_UVRAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARRB1ZBTB43, GNMT, KHK, NOLC1, AP3B1, TCOF1, CHD1, BOP1, ARR3, ARRB2, PES1, DDX27, KPNA3, ZRANB2, RPL7L1, CCL14, JAK1, RTF1, HDGFRP2, CSNK2A1, CMBL, CCR5, MAPK10, DVL2, DVL1, RALGDS, ARF6, CYTH2, OPRD1, CXCR2, ADRB1, CSK, MDM2, NSF, PTHLH, NEDD4, ITCH, CDC42, JUN, SREBF2, USP33, PARK2, HGS, STAM, SLC9A1, MAP3K5, STUB1, PDE4D, MAPK3, MAPK1, GSK3B, IGF1R, SAG, YWHAB, YWHAG, YWHAQ, YWHAH, YWHAE, YWHAZ, RANBP9, STK38, SCYL2, DGKZ, DGKE, DGKG, ROCK1, YES1, ATR, PPM1A, PPM1B, CLTA, CLTC, AP3D1, RAB11FIP5, LRP4, LRP1B, DNM1, RGS3, RAB1A, ANXA2, PTCH2, SDC3, HIST1H1C, HIST1H2BO, HIST2H4A, HIST2H2AB, H3F3B, PRMT5, NPM1, POLR1A, POLR1C, POLR1E, CD3EAP, THRAP3, TMPO, YBX1, ALYREF, NOP10, RBM10, SF3B2, NCL, SNRPD1, SRRM2, HNRNPM, HNRNPK, DKC1, HNRNPA3, EIF4B, EEF1A2, RPL22, RPS3A, RPS17, IGF2BP2, ACTA1, TUBA4A, TUBA3C, TUBA1C, TUBB, VIM, TUBB2A, FLNA, GSN, LIMA1, MPRIP, CALD1, MAP1B, SPTAN1, TPM4, CKAP4, MYH9, MYL12B, KIF26A, MYH1, FASN, PKM, DHRS2, ATP5A1, ATP5B, PFKFB3, P4HB, HSPA8, HSP90AA1, CNGA3, HSPA5, APLP1, HSPA9, BCLAF1, RPS27A, UBB, UBC, UBA52, CPA1, CSN2, WDR77, DGKH, STK38L, MAP3K1, PIK3R2, PIK3C2A, STXBP5, CPNE8, ARHGAP32, G3BP1, S100A9, ZYX, HIST1H2AG, H2AFX, H1FX, XRCC5, POLR2E, BACH2, HNRNPU, HNRNPH1, HNRNPA1, RPL3, RPS2, RPS8, RPL6, RPL7A, EIF3I, TMOD3, CFL1, CTTN, ARPC5, KTN1, TTN, INA, DMD, MYO1C, MYL6, KIF2C, KIF3A, DNAH3, ACACA, HSPA1B, HSPA7, KCTD3, USP24, SPIN1, HDLBP, DPY30, CALM3, PRPF4, POT1, ADRBK1, TRAF6, HCRTR1, GNB1, GNG2, SNCA, SLC9A5, GPR50, C5AR1, ARRDC3, ARRDC4, NFKBIA, YY1, EDNRA, SRC, AXIN1, MAP2K4, AGTR1, AKT1, PDXP, LIMK1, PTAFR, AP2A1, MAP2K3, MAPK14, ARRDC1, NOTCH1, RPL15, BAG1, NEK6, BTK, ADH6, MAPK9, PTGER4, EGFR, CYTH1, DRD4, KLHL12, CUL3, KBTBD8, BRPF1, DOCK4, ALDH4A1, LYRM7, ACIN1, DCAF5, ELMO2UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARRB1chr11:75062632chr11:75599873ENST00000360025-11545_866411CHRM2
HgeneARRB1chr11:75062632chr11:75599873ENST00000420843-11645_866419CHRM2
HgeneARRB1chr11:75062632chr11:75599873ENST00000360025-1151_1636411SRC
HgeneARRB1chr11:75062632chr11:75599873ENST00000420843-1161_1636419SRC
HgeneARRB1chr11:75062632chr11:75599873ENST00000360025-115318_4186411TRAF6
HgeneARRB1chr11:75062632chr11:75599873ENST00000420843-116318_4186419TRAF6


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARRB1_UVRAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARRB1_UVRAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARRB1C0023890Liver Cirrhosis1CTD_human
HgeneARRB1C0041696Unipolar Depression1PSYGENET
HgeneARRB1C1269683Major Depressive Disorder1PSYGENET
HgeneARRB1C3178803Social Anhedonia1PSYGENET