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Fusion gene ID: 28436 |
FusionGeneSummary for PPP2R2D_CPNE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R2D_CPNE2 | Fusion gene ID: 28436 | Hgene | Tgene | Gene symbol | PPP2R2D | CPNE2 | Gene ID | 55844 | 221184 |
| Gene name | protein phosphatase 2 regulatory subunit Bdelta | copine 2 | |
| Synonyms | B55D|B55delta|MDS026 | COPN2|CPN2 | |
| Cytomap | 10q26.3 | 16q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformPP2A subunit B isoform B55-deltaPP2A subunit B isoform PR55-deltaPP2A subunit B isoform R2-deltaPP2A subunit B isoform deltaprotein phosphatase 2 regulatory subunit B, d | copine-2copine II | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q66LE6 | Q96FN4 | |
| Ensembl transtripts involved in fusion gene | ENST00000422256, ENST00000470416, | ENST00000290776, ENST00000537605, ENST00000535318, ENST00000565874, ENST00000565951, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/4*10)=2.90689059560852 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP2R2D [Title/Abstract] AND CPNE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF542551 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + | ||
| ChiTaRS3.1 | BC010627 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000422256 | ENST00000290776 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| 3UTR-5UTR | ENST00000422256 | ENST00000537605 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| 3UTR-5UTR | ENST00000422256 | ENST00000535318 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| 3UTR-5UTR | ENST00000422256 | ENST00000565874 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| 3UTR-intron | ENST00000422256 | ENST00000565951 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| intron-3CDS | ENST00000470416 | ENST00000290776 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| intron-5UTR | ENST00000470416 | ENST00000537605 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| intron-5UTR | ENST00000470416 | ENST00000535318 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| intron-5UTR | ENST00000470416 | ENST00000565874 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
| intron-intron | ENST00000470416 | ENST00000565951 | PPP2R2D | chr10 | 133769311 | + | CPNE2 | chr16 | 57144810 | + |
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FusionProtFeatures for PPP2R2D_CPNE2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R2D | CPNE2 |
| B regulatory subunit of protein phosphatase 2A (PP2A)that plays a key role in cell cycle by controlling mitosis entryand exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high ininterphase and low in mitosis. During mitosis, activity of PP2A isinhibited via interaction with phosphorylated ENSA and ARPP19inhibitors. Within the PP2A complexes, the B regulatory subunitsmodulate substrate selectivity and catalytic activity, and alsomay direct the localization of the catalytic enzyme to aparticular subcellular compartment (By similarity). {ECO:0000250}. | Calcium-dependent phospholipid-binding protein thatplays a role in calcium-mediated intracellular processes. Exhibitscalcium-dependent cell membrane binding properties.{ECO:0000250|UniProtKB:P59108}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP2R2D_CPNE2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP2R2D_CPNE2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP2R2D_CPNE2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP2R2D_CPNE2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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