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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28422

FusionGeneSummary for PPP2R2A_MATR3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2A_MATR3
Fusion gene ID: 28422
HgeneTgene
Gene symbol

PPP2R2A

MATR3

Gene ID

5520

9782

Gene nameprotein phosphatase 2 regulatory subunit Balphamatrin 3
SynonymsB55A|B55ALPHA|PR52A|PR55A|PR55alphaALS21|MPD2|VCPDM
Cytomap

8p21.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformprotein phosphatase 2, regulatory subunit B, alphamatrin-3vocal cord and pharyngeal weakness with distal myopathy
Modification date2018052320180519
UniProtAcc

P63151

P43243

Ensembl transtripts involved in fusion geneENST00000380737, ENST00000315985, 
ENST00000523473, 
ENST00000509990, 
ENST00000361059, ENST00000504203, 
ENST00000502929, ENST00000394800, 
ENST00000507197, ENST00000394805, 
ENST00000502499, ENST00000510056, 
ENST00000503811, 
Fusion gene scores* DoF score15 X 9 X 8=10804 X 4 X 3=48
# samples 214
** MAII scorelog2(21/1080*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R2A [Title/Abstract] AND MATR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R2A

GO:0006470

protein dephosphorylation

1849734

TgeneMATR3

GO:0002218

activation of innate immune response

28712728

TgeneMATR3

GO:0010608

posttranscriptional regulation of gene expression

21771347


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A8NI-01APPP2R2Achr8

26151256

+MATR3chr5

138650364

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380737ENST00000509990PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
Frame-shiftENST00000380737ENST00000361059PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-5UTRENST00000380737ENST00000504203PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-5UTRENST00000380737ENST00000502929PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-5UTRENST00000380737ENST00000394800PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000380737ENST00000507197PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000380737ENST00000394805PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000380737ENST00000502499PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000380737ENST00000510056PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000380737ENST00000503811PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
Frame-shiftENST00000315985ENST00000509990PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
Frame-shiftENST00000315985ENST00000361059PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-5UTRENST00000315985ENST00000504203PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-5UTRENST00000315985ENST00000502929PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-5UTRENST00000315985ENST00000394800PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000315985ENST00000507197PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000315985ENST00000394805PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000315985ENST00000502499PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000315985ENST00000510056PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
5CDS-intronENST00000315985ENST00000503811PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-3CDSENST00000523473ENST00000509990PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-3CDSENST00000523473ENST00000361059PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-5UTRENST00000523473ENST00000504203PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-5UTRENST00000523473ENST00000502929PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-5UTRENST00000523473ENST00000394800PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-intronENST00000523473ENST00000507197PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-intronENST00000523473ENST00000394805PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-intronENST00000523473ENST00000502499PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-intronENST00000523473ENST00000510056PPP2R2Achr8

26151256

+MATR3chr5

138650364

+
3UTR-intronENST00000523473ENST00000503811PPP2R2Achr8

26151256

+MATR3chr5

138650364

+

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FusionProtFeatures for PPP2R2A_MATR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R2A

P63151

MATR3

P43243

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. May play a role in transcription or may interact withother nuclear matrix proteins to form the internal fibrogranularnetwork. In association with the SFPQ-NONO heteromer may play arole in nuclear retention of defective RNAs. Plays a role in theregulation of DNA virus-mediated innate immune response byassembling into the HDP-RNP complex, a complex that serves as aplatform for IRF3 phosphorylation and subsequent innate immuneresponse activation through the cGAS-STING pathway(PubMed:28712728). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:11525732,ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R2A_MATR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R2A_MATR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R2AFAM107A, TCEAL1, PPP2CA, PPP2R1B, EIF4EBP1, MTOR, RPS6KB1, RRN3, PPP2R1A, PPP2CB, TGFBR1, MLH1, PPP2R2D, CDCA4, SKIV2L2, CCT5, CCT8, CCT2, CCT4, CCT7, TUBA4A, CCT3, TCP1, FABP5, DSP, DSG1, CCT6A, GAPDH, HDAC5, NDRG1, ELAVL1, CUL3, PTPN14, GRK5, NOTCH1, SMURF1, GRB2, CFTR, EGFR, CDK17, CDK16, LATS2, HSPA4L, NRD1, CACNA1S, PPP3CA, THUMPD1, ABCE1, FAM122A, SERTAD4, IER2, RPS6KB2, NCAPD3, PPP2R5C, PPP2R5D, WDR4, NTRK1, AHI1, XPO1, PPME1, FOXC1, FOXC2, GC, RPS28, YARS, RBM7, RAB11FIP5, ECSIT, FBXL16, CRY2, MCM2, NOSIP, C1orf131, PTAR1, WWP2, DERL1, DUSP19, PHLPP1, PPP4C, PTPDC1, FOXD4, FAM19A3, AR, UBE2AMATR3HNRNPK, GSTK1, RUVBL2, CDK9, MEPCE, EGFR, H2AFX, UBC, CALM1, DISC1, TNFRSF21, AIMP2, SNAP23, SMARCAD1, NFX1, CUL3, CDK2, CUL1, COPS5, CAND1, NEDD8, GFI1B, PCBP1, SMU1, SAP18, STOML2, RANBP2, UTP14A, IARS2, RRP7A, PPT2, S100A9, SARS2, RRS1, NAA15, PRKCDBP, MYOF, MRPL19, MAGOH, EIF4A3, FN1, PTBP2, IFIT2, MAP1LC3A, ITGA4, PAN2, TARDBP, PARK2, RPA3, RPA2, RPA1, WWOX, ERG, LGR4, STAU1, AURKA, CEP250, MATR3, RASD1, CUL7, OBSL1, CCDC8, UBE2I, EED, SIRT6, HNRNPA1, FBXW11, UNK, NTRK1, BTF3, CALR, EEF1D, HNRNPU, ATP5A1, PUF60, RPL7, RUVBL1, SF3A3, SNRNP70, SNRPC, SRSF3, SUB1, YBX1, SRPK2, B9D2, ADAR, COPA, DDX3X, DDX5, DHX9, EWSR1, FUS, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPL, ILF2, ILF3, HNRNPM, NAP1L4, NUMA1, PKP2, PPP1CA, PPP1CB, PTBP1, RBM3, RCN1, SAFB, SET, SNRPA, TAF15, PKP4, EIF3D, SRSF9, TNK1, FUBP3, APOBEC3B, SAFB2, PUM1, MPHOSPH8, HNRNPDL, PTBP3, DNAJB6, SUGP2, RBM6, ALYREF, HNRNPR, AKAP8, RBM14, DDX17, KHDRBS1, HNRNPA0, HNRNPUL1, PKP3, RALY, FAM120A, FAM208A, RBFOX2, TIMM13, AKAP8L, STAU2, RBMX, ZNF638, RBM15B, RTCB, PPHLN1, C14orf166, POLR3B, DDX28, YLPM1, NCOA5, SQRDL, ZNF106, ZNF668, SLTM, PRR3, RBM4B, GSG2, DPY30, NLRP5, ESCO2, HNRNPA3, HNRNPUL2, CXorf23, ZNF326, RBM12B, EIF2AK4, RBMXL1, CRY1, CRY2, ALKBH3, MCM5, SENP3, U2AF2, RC3H1, CRBN, ELAVL2, CDK5RAP1, CYLD, TRIM25, BRCA1, LMNA, YAP1, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R2A_MATR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R2A_MATR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R2AC0013990Pathological accumulation of air in tissues1CTD_human
HgenePPP2R2AC1257806Chromosomal Instability1CTD_human
HgenePPP2R2AC1449861Micronuclei, Chromosome-Defective1CTD_human
TgeneMATR3C3807521AMYOTROPHIC LATERAL SCLEROSIS 212ORPHANET;UNIPROT