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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28414

FusionGeneSummary for PPP2R1B_IDH2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R1B_IDH2
Fusion gene ID: 28414
HgeneTgene
Gene symbol

PPP2R1B

IDH2

Gene ID

5519

3418

Gene nameprotein phosphatase 2 scaffold subunit Abetaisocitrate dehydrogenase (NADP(+)) 2, mitochondrial
SynonymsPP2A-Abeta|PR65BD2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH
Cytomap

11q23.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPP2A, subunit A, PR65-beta isoformPP2A, subunit A, R1-beta isoformprotein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoformprotein phosphatase 2, regulatory isocitrate dehydrogenase [NADP], mitochondrialNADP(+)-specific ICDHisocitrate dehydrogenase 2 (NADP+), mitochondrialoxalosuccinate decarboxylase
Modification date2018052320180522
UniProtAcc

P30154

P48735

Ensembl transtripts involved in fusion geneENST00000311129, ENST00000426998, 
ENST00000530787, ENST00000527614, 
ENST00000427203, ENST00000341980, 
ENST00000393055, 
ENST00000330062, 
ENST00000539790, ENST00000559482, 
ENST00000540499, 
Fusion gene scores* DoF score2 X 3 X 3=184 X 4 X 3=48
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP2R1B [Title/Abstract] AND IDH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-7298-01APPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000311129ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000311129ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000311129ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-5UTRENST00000311129ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
Frame-shitENST00000426998ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000426998ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000426998ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-5UTRENST00000426998ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
intron-3CDSENST00000530787ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
intron-intronENST00000530787ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
intron-intronENST00000530787ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
intron-5UTRENST00000530787ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
Frame-shitENST00000527614ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000527614ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000527614ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-5UTRENST00000527614ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
Frame-shitENST00000427203ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000427203ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000427203ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-5UTRENST00000427203ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
Frame-shitENST00000341980ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000341980ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000341980ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-5UTRENST00000341980ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
Frame-shitENST00000393055ENST00000330062PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000393055ENST00000539790PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-intronENST00000393055ENST00000559482PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-
5CDS-5UTRENST00000393055ENST00000540499PPP2R1Bchr11

111613247

-IDH2chr15

90634876

-

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FusionProtFeatures for PPP2R1B_IDH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R1B

P30154

IDH2

P48735

Plays a role in intermediary metabolism and energyproduction. It may tightly associate or interact with the pyruvatedehydrogenase complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R1B_IDH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R1B_IDH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R1BPPP2R2A, CTTNBP2NL, MOB4, PDCD10, PPP2CA, PPP2R1A, STK24, STK25, STRN, PPP2R2C, PPP2R5A, JAK2, PPP2CB, PPP2R3B, PPP2R5D, PPP2R5C, PPP2R5B, PPP2R5E, TNFAIP3, ZRANB1, USP53, INTS1, INTS3, INTS5, INTS6, PPP2R2B, PPP2R2D, PRKAA1, RALA, STRN3, CDK1, CDK4, HDAC1, MCM3, PRDX1, PRDX2, PARK7, RAB18, RAB7A, RAB11A, MARCH1, EEF2, ANXA5, FGFR1, STAT3, CAV1, CFTR, POLA1, FBXW4, EGFR, DNAAF5, ARPC1A, ARPC5, IKBKG, UNC5B, DAPK1, CSNK2B, DEC1, RORC, CLOCK, CRY1, CRY2, BHLHE41, FBXW11, PPP2R1B, ZNF219, FOXS1, SERTAD4, FAM43A, SGOL2, WNT3A, ZNF114, IER2, SLMAP, PDCD4, ACADM, CLTC, SLC25A3, RPN1, NCBP1, PPP4R1, FGFR1OP2, SIKE1, FOXO3, SNW1, VPRBP, PPP2R3A, FOXD4, TBCCD1, CDCA4, PRR14, PTPDC1, ZNF550, TRIM35, TRAF3IP3, NCAPD3, FAM19A3, ZNF331, ZNF785, TRIM25IDH2CDK2, HDAC1, ADRB2, PYGL, EGFR, KCMF1, IDH1, G6PD, IDH3A, IDH3B, IDH3G, NTRK1, MUS81, KBTBD7, ZNF746, SLC39A9, C1orf85, MAS1, SLC15A1, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, EIF5B, GPI, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, COQ2, SOAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R1B_IDH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R1B_IDH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIDH2C0014084Enchondromatosis2CTD_human;HPO;ORPHANET
TgeneIDH2C0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneIDH2C0936248Chondroma2CTD_human
TgeneIDH2C2750850GLIOMA SUSCEPTIBILITY 12UNIPROT
TgeneIDH2C0018916Hemangioma1CTD_human
TgeneIDH2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
TgeneIDH2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneIDH2C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneIDH2C0027643Neoplasm Recurrence, Local1CTD_human
TgeneIDH2C0028945oligodendroglioma1CTD_human;ORPHANET
TgeneIDH2C0029408Degenerative polyarthritis1CTD_human
TgeneIDH2C0029456Osteoporosis1CTD_human
TgeneIDH2C0206698Cholangiocarcinoma1CTD_human
TgeneIDH2C3150909D-2-HYDROXYGLUTARIC ACIDURIA 21UNIPROT