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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28385

FusionGeneSummary for PPP1R3F_PPP1R3F

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R3F_PPP1R3F
Fusion gene ID: 28385
HgeneTgene
Gene symbol

PPP1R3F

PPP1R3F

Gene ID

89801

89801

Gene nameprotein phosphatase 1 regulatory subunit 3Fprotein phosphatase 1 regulatory subunit 3F
SynonymsHB2E|LL0XNC01-7P3.1|R3FHB2E|LL0XNC01-7P3.1|R3F
Cytomap

Xp11.23

Xp11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 3Fprotein phosphatase 1, regulatory (inhibitor) subunit 3Fprotein phosphatase 1 regulatory subunit 3Fprotein phosphatase 1, regulatory (inhibitor) subunit 3F
Modification date2018051920180519
UniProtAcc

Q6ZSY5

Q6ZSY5

Ensembl transtripts involved in fusion geneENST00000438316, ENST00000466508, 
ENST00000055335, ENST00000495799, 
ENST00000376188, 		ENST00000438316, 
ENST00000466508, ENST00000055335, 
ENST00000495799, ENST00000376188, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: PPP1R3F [Title/Abstract] AND PPP1R3F [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R3F

GO:0005979

regulation of glycogen biosynthetic process

21668450

HgenePPP1R3F

GO:2000465

regulation of glycogen (starch) synthase activity

21668450

TgenePPP1R3F

GO:0005979

regulation of glycogen biosynthetic process

21668450

TgenePPP1R3F

GO:2000465

regulation of glycogen (starch) synthase activity

21668450


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI457539PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000438316ENST00000438316PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000438316ENST00000466508PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000438316ENST00000055335PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000438316ENST00000495799PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000438316ENST00000376188PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000466508ENST00000438316PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000466508ENST00000466508PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000466508ENST00000055335PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000466508ENST00000495799PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000466508ENST00000376188PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
5CDS-5UTRENST00000055335ENST00000438316PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
5CDS-5UTRENST00000055335ENST00000466508PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
5CDS-5UTRENST00000055335ENST00000055335PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
5CDS-intronENST00000055335ENST00000495799PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
5CDS-intronENST00000055335ENST00000376188PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000495799ENST00000438316PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000495799ENST00000466508PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000495799ENST00000055335PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000495799ENST00000495799PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000495799ENST00000376188PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000376188ENST00000438316PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000376188ENST00000466508PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-5UTRENST00000376188ENST00000055335PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000376188ENST00000495799PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+
intron-intronENST00000376188ENST00000376188PPP1R3FchrX

49126907

-PPP1R3FchrX

49127116

+

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FusionProtFeatures for PPP1R3F_PPP1R3F


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R3F

Q6ZSY5

PPP1R3F

Q6ZSY5

Glycogen-targeting subunit for protein phosphatase 1(PP1). {ECO:0000269|PubMed:21668450}. Glycogen-targeting subunit for protein phosphatase 1(PP1). {ECO:0000269|PubMed:21668450}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R3F_PPP1R3F


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R3F_PPP1R3F


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R3F_PPP1R3F


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R3F_PPP1R3F


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource