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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28375

FusionGeneSummary for PPP1R37_PAFAH1B3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R37_PAFAH1B3
Fusion gene ID: 28375
HgeneTgene
Gene symbol

PPP1R37

PAFAH1B3

Gene ID

284352

5050

Gene nameprotein phosphatase 1 regulatory subunit 37platelet activating factor acetylhydrolase 1b catalytic subunit 3
SynonymsLRRC68PAFAHG
Cytomap

19q13.32

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68platelet-activating factor acetylhydrolase IB subunit gammaPAF acetylhydrolase 29 kDa subunitPAF-AH 29 kDa subunitPAF-AH subunit gammaPAF-AH1b alpha 1 subunitPAFAH subunit gammaplatelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kD
Modification date2018051920180523
UniProtAcc

O75864

Q15102

Ensembl transtripts involved in fusion geneENST00000421905, ENST00000221462, 
ENST00000496125, 
ENST00000262890, 
ENST00000538771, 
Fusion gene scores* DoF score12 X 2 X 9=2161 X 1 X 1=1
# samples 121
** MAII scorelog2(12/216*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PPP1R37 [Title/Abstract] AND PAFAH1B3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R37

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1558-01APPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000421905ENST00000262890PPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-
5CDS-5UTRENST00000421905ENST00000538771PPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-
5CDS-5UTRENST00000221462ENST00000262890PPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-
5CDS-5UTRENST00000221462ENST00000538771PPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-
3UTR-5UTRENST00000496125ENST00000262890PPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-
3UTR-5UTRENST00000496125ENST00000538771PPP1R37chr19

45596785

+PAFAH1B3chr19

42806477

-

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FusionProtFeatures for PPP1R37_PAFAH1B3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R37

O75864

PAFAH1B3

Q15102

Inhibits phosphatase activity of protein phosphatase 1(PP1) complexes. {ECO:0000269|PubMed:19389623}. Inactivates paf by removing the acetyl group at the sn-2position. This is a catalytic subunit. Plays an important roleduring the development of brain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R37_PAFAH1B3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R37_PAFAH1B3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R37ZMYND19, BEND7, PPP1CA, DCP1A, SEH1L, CDH1PAFAH1B3PAFAH1B2, LNX1, PAFAH1B3, CHMP7, SDCBP2, HSPH1, DDX24, ECH1, GBP2, GDF9, CCDC90B, IGSF21, PLEKHM1, C14orf1, COPS6, XRCC6, SETDB1, ZHX1, ZBTB16, MED31, RBM48, GAPDH, LRIF1, TLE1, TP53, TUBB2A, UNC119, BRD7, CRMP1, EEF1A1, PAFAH1B1, TERF1, TERF2IP, VCAM1, ITGA4, HNRNPD, LDHA, LDHB, CUL7, C14orf166, VARS, NTRK1, DLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R37_PAFAH1B3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R37_PAFAH1B3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource