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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28374

FusionGeneSummary for PPP1R37_IGSF23

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R37_IGSF23
Fusion gene ID: 28374
HgeneTgene
Gene symbol

PPP1R37

IGSF23

Gene ID

284352

147710

Gene nameprotein phosphatase 1 regulatory subunit 37immunoglobulin superfamily member 23
SynonymsLRRC68-
Cytomap

19q13.32

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68immunoglobulin superfamily member 23
Modification date2018051920180329
UniProtAcc

O75864

A1L1A6

Ensembl transtripts involved in fusion geneENST00000421905, ENST00000221462, 
ENST00000496125, 
ENST00000402988, 
Fusion gene scores* DoF score12 X 2 X 9=2165 X 4 X 4=80
# samples 125
** MAII scorelog2(12/216*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R37 [Title/Abstract] AND IGSF23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R37

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1403-01APPP1R37chr19

45596785

+IGSF23chr19

45127000

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000421905ENST00000402988PPP1R37chr19

45596785

+IGSF23chr19

45127000

+
Frame-shiftENST00000221462ENST00000402988PPP1R37chr19

45596785

+IGSF23chr19

45127000

+
3UTR-3CDSENST00000496125ENST00000402988PPP1R37chr19

45596785

+IGSF23chr19

45127000

+

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FusionProtFeatures for PPP1R37_IGSF23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R37

O75864

IGSF23

A1L1A6

Inhibits phosphatase activity of protein phosphatase 1(PP1) complexes. {ECO:0000269|PubMed:19389623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R37_IGSF23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R37_IGSF23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R37ZMYND19, BEND7, PPP1CA, DCP1A, SEH1L, CDH1IGSF23


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R37_IGSF23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R37_IGSF23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource