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Fusion gene ID: 28366 |
FusionGeneSummary for PPP1R2_GMNC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP1R2_GMNC | Fusion gene ID: 28366 | Hgene | Tgene | Gene symbol | PPP1R2 | GMNC | Gene ID | 5504 | 647309 |
| Gene name | protein phosphatase 1 regulatory inhibitor subunit 2 | geminin coiled-coil domain containing | |
| Synonyms | IPP-2|IPP2|PPP1R2A | GEMC1 | |
| Cytomap | 3q29 | 3q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase inhibitor 2phosphoprotein phosphatase | geminin coiled-coil domain-containing protein 1 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | P41236 | A6NCL1 | |
| Ensembl transtripts involved in fusion gene | ENST00000328432, | ENST00000442080, ENST00000479491, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PPP1R2 [Title/Abstract] AND GMNC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CQ-A4CB-01A | PPP1R2 | chr3 | 195269727 | - | GMNC | chr3 | 190578647 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328432 | ENST00000442080 | PPP1R2 | chr3 | 195269727 | - | GMNC | chr3 | 190578647 | - |
| 5CDS-intron | ENST00000328432 | ENST00000479491 | PPP1R2 | chr3 | 195269727 | - | GMNC | chr3 | 190578647 | - |
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FusionProtFeatures for PPP1R2_GMNC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP1R2 | GMNC |
| Inhibitor of protein-phosphatase 1. | Regulator of DNA replication. Promotes initiation ofchromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPP1R2 | chr3:195269727 | chr3:190578647 | ENST00000328432 | - | 1 | 6 | 12_17 | 40 | 206 | Region | Required for binding PPP1CC |
| Tgene | >GMNC | chr3:195269727 | chr3:190578647 | ENST00000442080 | - | 0 | 5 | 82_119 | 1 | 335 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPP1R2 | chr3:195269727 | chr3:190578647 | ENST00000328432 | - | 1 | 6 | 147_150 | 40 | 206 | Region | Required for binding PPP1CC catalytic center%2C displacing metal ions and inhibition of PPP1CC catalytic activity |
| Hgene | >PPP1R2 | chr3:195269727 | chr3:190578647 | ENST00000328432 | - | 1 | 6 | 43_55 | 40 | 206 | Region | Required for binding PPP1CC |
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FusionGeneSequence for PPP1R2_GMNC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPP1R2_ENST00000328432_chr3_195269727_-_GMNC_ENST00000442080_chr3_190578647_-_374aa MAASTASHRPIKGILKNKTSTTSSMVASAEQPRGNVDEELRTPFCLAKTSTLXEARAIIARIPLQRQNLVLTFPRRLGSLSGLLVSWTTE SSNKHHRHRNHSVTQIFLFRTCAHGKRLSFPLSSTEISSCKIPWCRRKKNSPGYTKRIITSDNTXILLWLNVLKKRPRNCSHLMSSPKHM ENSGRGRENPKSKDTLLLRFPIPKMPKETSLVNLLTVKNKLGPLWIPGSFKHLGXKTLTLSMTPHQLTTVPSHLIPEESPAHFPSFRMMQ LIIKISPERICQLTIEVTEQPPCTALPLMEKISTSFLNFQIPQWGXKLFLTILLMCHPTRQRWHFPHPXALIVMXKLIPSTRDKPLCVEM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPP1R2_ENST00000328432_chr3_195269727_-_GMNC_ENST00000442080_chr3_190578647_-_1124nt ATGGCGGCCTCGACGGCCTCGCACCGGCCCATCAAGGGGATCTTGAAGAACAAGACCTCTACGACTTCCTCTATGGTGGCGTCGGCCGAA CAGCCCCGCGGGAATGTCGACGAGGAGCTGAGAACACCATTCTGCCTTGCCAAGACCAGTACTTTGTAGGAGGCCAGAGCTATAATTGCC CGTATTCCACTACAACGTCAGAATCTAGTGTTGACGTTTCCACGGAGACTTGGGTCTCTTTCTGGGCTGCTGGTCTCCTGGACAACAGAG AGCTCCAACAAGCACCACAGGCACAGGAATCATTCAGTGACTCAAATTTTCCTCTTCCGGACTTGTGCTCATGGGAAGAGGCTCAGCTTT CCTCTCAGCTCTACAGAAATAAGCAGCTGCAAGATACCCTGGTGCAGAAGGAAGAAGAACTCGCCAGGTTACACGAAGAGAATAATCACC TCAGACAATACCTGAATTCTGCTTTGGTTAAATGTCTTGAAGAAAAGGCCAAGAAATTGCTCTCATCTGATGAGTTCTCCAAAGCATATG GAAAATTCAGGAAGGGGAAGAGAAAATCCAAAGAGCAAAGATACTCTCCTGCTGAGATTCCCCATCCCAAAAATGCCAAAAGAAACCTCT CTAGTGAATTTGCTAACTGTGAAGAACAAGCTGGGCCCCCTGTGGATCCCTGGGTCCTTCAAACACTTGGGTTAAAAGACCTTGACACTA TCGATGACACCTCATCAGCTAACTACAGTGCCCTCGCATCTCATCCCAGAAGAGTCGCCAGCACATTTTCCCAGTTTCCGGATGATGCAG TTGATTATAAAAATATCCCCAGAGAGGATATGCCAATTGACTATAGAGGTGACAGAACAACCCCCTTGCACAGCACTGCCACTCATGGAG AAGATTTCCACATCCTTTCTCAACTTTCAAATCCCCCAGTGGGGCTGAAAACTCTTCCTTACTATACTGCTCATGTGTCACCCAACAAGA CAGAGATGGCATTTTCCACATCCCTGAGCCCTCATTGTAATGTGAAAACTCATTCCTTCCACCAGGGACAAGCCTTTGTGCGTCGAGATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPP1R2_ENST00000328432_chr3_195269727_-_GMNC_ENST00000442080_chr3_190578647_-_3902nt GTTCTCGCCCCGCCCTCTCCCCGCCTCCTCCCTAGATATCGCGAGAGGGCGGGTCCGCTTGGCTTCGGCGTCGCGTCGCTCCTGCGCTGG AGCTCTAGGCCGGCGTCTCTCCGCGAGCCGCGGGTCAAGTGGCAGTGGCTAAGGGTGCGCGAGTAGCCGCCACCCGTTCGGCGTTGGCTC TGGCGTCGGGGTCGTTGTGTCGTGACAACCGCTGCGGTAGCCGTTTCCGAGGCAGCAGTTGCGGCCGCTTTAGCCCTGAGCGGGATCTGC GGCTGCCTGCGAGTCTCTGCTGTGCCGACCCTTCTCTTCGCGGACCCCACGCCAAGCAGCGACCCTGAGCCGACAGCCGGAGCGCCCGGC AATGGCGGCCTCGACGGCCTCGCACCGGCCCATCAAGGGGATCTTGAAGAACAAGACCTCTACGACTTCCTCTATGGTGGCGTCGGCCGA ACAGCCCCGCGGGAATGTCGACGAGGAGCTGAGAACACCATTCTGCCTTGCCAAGACCAGTACTTTGTAGGAGGCCAGAGCTATAATTGC CCGTATTCCACTACAACGTCAGAATCTAGTGTTGACGTTTCCACGGAGACTTGGGTCTCTTTCTGGGCTGCTGGTCTCCTGGACAACAGA GAGCTCCAACAAGCACCACAGGCACAGGAATCATTCAGTGACTCAAATTTTCCTCTTCCGGACTTGTGCTCATGGGAAGAGGCTCAGCTT TCCTCTCAGCTCTACAGAAATAAGCAGCTGCAAGATACCCTGGTGCAGAAGGAAGAAGAACTCGCCAGGTTACACGAAGAGAATAATCAC CTCAGACAATACCTGAATTCTGCTTTGGTTAAATGTCTTGAAGAAAAGGCCAAGAAATTGCTCTCATCTGATGAGTTCTCCAAAGCATAT GGAAAATTCAGGAAGGGGAAGAGAAAATCCAAAGAGCAAAGATACTCTCCTGCTGAGATTCCCCATCCCAAAAATGCCAAAAGAAACCTC TCTAGTGAATTTGCTAACTGTGAAGAACAAGCTGGGCCCCCTGTGGATCCCTGGGTCCTTCAAACACTTGGGTTAAAAGACCTTGACACT ATCGATGACACCTCATCAGCTAACTACAGTGCCCTCGCATCTCATCCCAGAAGAGTCGCCAGCACATTTTCCCAGTTTCCGGATGATGCA GTTGATTATAAAAATATCCCCAGAGAGGATATGCCAATTGACTATAGAGGTGACAGAACAACCCCCTTGCACAGCACTGCCACTCATGGA GAAGATTTCCACATCCTTTCTCAACTTTCAAATCCCCCAGTGGGGCTGAAAACTCTTCCTTACTATACTGCTCATGTGTCACCCAACAAG ACAGAGATGGCATTTTCCACATCCCTGAGCCCTCATTGTAATGTGAAAACTCATTCCTTCCACCAGGGACAAGCCTTTGTGCGTCGAGAT GAGGAGGGAGGCTGGAAGTTTACCTGGGTCCCTAAGCAGTCTTAGTGACCCCTCTTTTATCACAAAGCACTGCCACGAACTCTGTTTACA AAGACCTCTCTTGCACTTGAATTTGACTATGTGGAACACAGAAGCTGTTGCTTAGACTGTCTCCTGCCACTTTAAATGTCACTCTCAATT ACCCACTTAAATCTGCAGGGAATGGCTTCCAAGAATCCATAATGAAACGTGTCCGCGCTTCTTTTACCTAAATTTGACTTGTTTACACAC CAATACCTGCTATTGACATCCTCTCTTTGCCCTATACTTGATAAGGTATTTTCCACTCACTTCTATATTCCTTTAAGACCTAGATACATT TTTCCAATTTTAACCAGTTTAACAGATTTTCCTCTTTTAAGTAGTTGAAATATTCACAGCCCTTTTACTTTTCTCCCTTTGTCATTTCTG AAAACTGTCTTTAGAATGAGCCCTATTTTTGCTTCAAGTACTTGCTACTGCATGTTCAAATAGCTGAGGGTGGGGTTGAAACAAGTGTCT TTGCCCATCACCACTACTCCTGAAGACATAATGTGGATGTGTGTAGCATTATGTTCATGGCAGTTCAAAAAGTTCAGTGCCCCATAGTGG CATTGACAAAGCCTCTTAAAACAACTGTAACTCCACTAATAATCAATATCACAGATAAACTTTAAAATTACAAAGAATTTAAATTATTTT TAAATGCCTCATGATGTATCAGCTTCTATATGTACCCAGCATCATTTCTTTAACCAACATGACTCCAAGAAGAACATTTTGAGGGACTGT GGTAACAAAACTAGTCATCATCTGCAACTACCCAGATGCTGACAAACTCCTATTGCTGAAAATAGACTAACCTAGCTCAGCCATTGTCTC ATTCATTCATTCATTCGCGTATTCATTTTTTCATTGATCAGTCCACCCAAGAAATCTGTAGAATACCTAATGCCTACTTTGTACCAGGCA CTATGCTATGTGATGGTGATAAAATACAAGCAATTTAGACACTGTGGCCACCATCATGAGACTTAGACCTACTCATCTGCTATGACTTTG CGAAAACGACTTCCCTTTTGTGAAGGTTCAGTTTCCCAACTGTAGAATACAGAAGTTGGACTAGATAATTACTAATATTCTATGAATTGA GGCTGGGTCCTATCAGATTTACTCCAACATGGCAGTTTCAGGTCACTGAAGAAACTAAAGAGAAGTCTTTAGATAGGCACTGCAAGTATT AGGTAGGGTAAACTTTATGTACAATTAATAAAATTCAAAAACATAAGTCATTTGAAGTTAACATTAGAAATCATTGCTCTGATCACAGTA CTCTTTTTCTAGAGCCCATTTTGCAGTTAACTCGGCGTAACTGTGTAAGAATAATTTGCCTCTAAAAATAGATACATATTAATTTTTAAA TAAGTGCGGATAGATTGCATATAAATATTGCTATCAAGGACTTCATATTTCTAAATTTGAAACAATATATTTTCAGTGCTTGTGCTAGTT TTCTTCTTTCCCATCTCTCAAGACCCCTATCATTCCCAGAATAATTTGCACATCCTGCATGTGCACCTATGTTTTTTGGACAAACTTCAA TTAATGATGAAATCTTTCATGTTGAAACCTGTTCTCATTTTTCTCTTTTCCACATCTCAATAAGTCATCTTGCACAATCAATATCTCGTA GGTCAACTGTGTTGGTTAGGATTCTTTGTAACAGAGACATGCCTTTCATTGTTGTTTCTGTTTGGTTGTTGCTTTATTTTGGTGATGTAA GCAAAGGGTCTGTTTTATAAAGTTTTGTTGCCACCCACTTTTAAAAATAATTTATGAAGAAAATCCAATATAGTAATTAATATTACTCTC TGGAGTACTTTAAGAAGTAGAACACATTCCATTTTCTAAAAAATAAAATAAAATAAATAACTGTGCCTTTTACATTCTGGTATCTGGGCC CCTGGTCGGTGAAATTTGTCGCTTTTTAGAATAAGAGATTTAAGGATTCGAATTATTGTACTTTATGACACTAGGAATTGAGAAAGTAAT ATAACTAATTTTGAAAGTCTAATAATCAAGCTGTAAAAGGAAATGTATGAGTTAACAAATATTTATTTTGCATTCTTTGTGTGCCTTATC ATGTGTTAAGTACCATGAGGGTACACCCAGGCTTAGCACAATGCATTTGGTATACAAAACCATGTAAAATGTCATAGCTTTTGATAGCTT TTAAATGAAACTTAATTTTGGCCCAGTTTAAAGATATTACCGAACATTTGGGATAAAATGTGATGGTTTCCTGGCTTCTATCATGGACGA TGTTATGGAAGACAATTACCACGTTTTTGAAATCATGTCTATAAATATTTAATATCCATTTAAATTATGTATAGAAAATTATTTTGTTCA |
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FusionGenePPI for PPP1R2_GMNC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP1R2 | PPP1CB, PPP1R9B, LMTK2, NEK2, PPP1CA, ELAVL1, TERF2IP, TINF2, PPP1CC, CIAPIN1, GSK3A, GSK3B, GINS4, ISOC1, DCPS, G6PD, MSN, NAE1, NCDN, NSFL1C, PDHA1, PDIA4, PRCP, PROSC, RAP1GDS1, TATDN1, TNFAIP8, TUFM, VCL, YWHAE, ZNF622, TP53BP2, PPP1R3A, PPP1R11, KDM2A, PDIA5, POLR2G, PPP1R7, SFN, SLK, SULT1C3, HIST1H2BG, EWSR1, THOC7, GTF2H5 | GMNC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP1R2_GMNC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP1R2_GMNC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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