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Fusion gene ID: 28364 |
FusionGeneSummary for PPP1R2_APOD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP1R2_APOD | Fusion gene ID: 28364 | Hgene | Tgene | Gene symbol | PPP1R2 | APOD | Gene ID | 5504 | 347 |
| Gene name | protein phosphatase 1 regulatory inhibitor subunit 2 | apolipoprotein D | |
| Synonyms | IPP-2|IPP2|PPP1R2A | - | |
| Cytomap | 3q29 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase inhibitor 2phosphoprotein phosphatase | apolipoprotein Dapo-D | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P41236 | P05090 | |
| Ensembl transtripts involved in fusion gene | ENST00000328432, | ENST00000343267, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 3 X 3=27 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPP1R2 [Title/Abstract] AND APOD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | APOD | GO:0000302 | response to reactive oxygen species | 18419796 |
| Tgene | APOD | GO:0006006 | glucose metabolic process | 19176353 |
| Tgene | APOD | GO:0006629 | lipid metabolic process | 19176353 |
| Tgene | APOD | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway | 14551159 |
| Tgene | APOD | GO:0042308 | negative regulation of protein import into nucleus | 14551159 |
| Tgene | APOD | GO:0048662 | negative regulation of smooth muscle cell proliferation | 14551159 |
| Tgene | APOD | GO:0060588 | negative regulation of lipoprotein lipid oxidation | 18419796 |
| Tgene | APOD | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production | 18842892 |
| Tgene | APOD | GO:1900016 | negative regulation of cytokine production involved in inflammatory response | 18842892 |
| Tgene | APOD | GO:2000405 | negative regulation of T cell migration | 18842892 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-OR-A5J1-01A | PPP1R2 | chr3 | 195269727 | - | APOD | chr3 | 195296006 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328432 | ENST00000343267 | PPP1R2 | chr3 | 195269727 | - | APOD | chr3 | 195296006 | - |
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FusionProtFeatures for PPP1R2_APOD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP1R2 | APOD |
| Inhibitor of protein-phosphatase 1. | APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in thetransport and binding of bilin. Appears to be able to transport avariety of ligands in a number of different contexts. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPP1R2 | chr3:195269727 | chr3:195296006 | ENST00000328432 | - | 1 | 6 | 12_17 | 40 | 206 | Region | Required for binding PPP1CC |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPP1R2 | chr3:195269727 | chr3:195296006 | ENST00000328432 | - | 1 | 6 | 147_150 | 40 | 206 | Region | Required for binding PPP1CC catalytic center%2C displacing metal ions and inhibition of PPP1CC catalytic activity |
| Hgene | >PPP1R2 | chr3:195269727 | chr3:195296006 | ENST00000328432 | - | 1 | 6 | 43_55 | 40 | 206 | Region | Required for binding PPP1CC |
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FusionGeneSequence for PPP1R2_APOD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP1R2_APOD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP1R2 | PPP1CB, PPP1R9B, LMTK2, NEK2, PPP1CA, ELAVL1, TERF2IP, TINF2, PPP1CC, CIAPIN1, GSK3A, GSK3B, GINS4, ISOC1, DCPS, G6PD, MSN, NAE1, NCDN, NSFL1C, PDHA1, PDIA4, PRCP, PROSC, RAP1GDS1, TATDN1, TNFAIP8, TUFM, VCL, YWHAE, ZNF622, TP53BP2, PPP1R3A, PPP1R11, KDM2A, PDIA5, POLR2G, PPP1R7, SFN, SLK, SULT1C3, HIST1H2BG, EWSR1, THOC7, GTF2H5 | APOD | STK24, POLR2M, APOD, APOA2, CUL2, CDK2, SHBG, ESR1, APOA1, CDK19, VAPA, RPE, HAX1, DPPA4, SUMF2, RNF126, CREB3, ATF6, ATP2B2, DHX57, KIAA0355, ARHGAP36, ALCAM, EFEMP1, MAZ, MTMR9, VNN2, GK, ZIC1, GPR3, TSNARE1, CYR61, RNASE13, SERPINE2, SLC35C1, PVRL2, TOR1A, FAM60A, FCRL1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP1R2_APOD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | APOD | P05090 | DB00162 | Vitamin A | Apolipoprotein D | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for PPP1R2_APOD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | APOD | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | APOD | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | APOD | C0017638 | Glioma | 1 | CTD_human |
| Tgene | APOD | C0023186 | Learning Disorders | 1 | CTD_human |
| Tgene | APOD | C0086439 | Hypokinesia | 1 | CTD_human |
| Tgene | APOD | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
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