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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28363

FusionGeneSummary for PPP1R21_ZBTB20

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R21_ZBTB20
Fusion gene ID: 28363
HgeneTgene
Gene symbol

PPP1R21

ZBTB20

Gene ID

129285

26137

Gene nameprotein phosphatase 1 regulatory subunit 21zinc finger and BTB domain containing 20
SynonymsCCDC128|KLRAQ1DPZF|HOF|ODA-8S|PRIMS|ZNF288
Cytomap

2p16.3

3q13.31

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 21KLRAQ motif containing 1KLRAQ motif-containing protein 1coiled-coil domain containing 128coiled-coil domain-containing protein 128zinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288
Modification date2018051920180526
UniProtAcc

Q6ZMI0

Q9HC78

Ensembl transtripts involved in fusion geneENST00000281394, ENST00000294952, 
ENST00000449090, ENST00000476199, 
ENST00000462705, ENST00000393785, 
ENST00000481632, ENST00000471418, 
ENST00000357258, ENST00000464560, 
ENST00000488663, ENST00000474710, 
Fusion gene scores* DoF score5 X 5 X 4=1005 X 5 X 4=100
# samples 55
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R21 [Title/Abstract] AND ZBTB20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A27H-01APPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000281394ENST00000462705PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000393785PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000481632PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000471418PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000357258PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000464560PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000488663PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000281394ENST00000474710PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000462705PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000393785PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000481632PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000471418PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000357258PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000464560PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000488663PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000294952ENST00000474710PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000462705PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000393785PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000481632PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000471418PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000357258PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000464560PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000488663PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
5CDS-intronENST00000449090ENST00000474710PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000462705PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000393785PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000481632PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000471418PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000357258PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000464560PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000488663PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-
intron-intronENST00000476199ENST00000474710PPP1R21chr2

48713897

+ZBTB20chr3

114301113

-

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FusionProtFeatures for PPP1R21_ZBTB20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R21

Q6ZMI0

ZBTB20

Q9HC78

May be a transcription factor that may be involved inhematopoiesis, oncogenesis, and immune responses(PubMed:11352661). Plays a role in postnatal myogenesis, may beinvolved in the regulation of satellite cells self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q8K0L9,ECO:0000269|PubMed:11352661}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R21_ZBTB20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R21_ZBTB20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R21SH3GL2, CUL2, TXNDC5, ZDHHC17, CRYZL1, PIBF1, SH2D2A, CEP170, FEN1, MYBPH, TAF6, TOX4, CEP162, ERC1, MRPL18, NDUFAF1, C12orf4, TBCK, PDDC1, KMT2D, TCP10L, IL6R, FBXL14, THBS2, WDTC1, KBTBD7, BTBD9, KLHL26, KLHL24, KBTBD6, TXLNA, KCTD10, MTNR1BZBTB20NR3C1, PPARG, CHD7, ELAVL1, HSP90AA1, FLNA, MYH9, IQGAP1, SYNPO, LIMA1, ANLN, MYO19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R21_ZBTB20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R21_ZBTB20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZBTB20C0038356Stomach Neoplasms1CTD_human
TgeneZBTB20C0796121Primrose syndrome1CTD_human;ORPHANET;UNIPROT