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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28350

FusionGeneSummary for PPP1R18_PNMA5

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R18_PNMA5
Fusion gene ID: 28350
HgeneTgene
Gene symbol

PPP1R18

PNMA5

Gene ID

170954

114824

Gene nameprotein phosphatase 1 regulatory subunit 18PNMA family member 5
SynonymsHKMT1098|KIAA1949-
Cytomap

6p21.33

Xq28

Type of geneprotein-codingprotein-coding
Descriptionphostensinprotein phosphatase 1 F-actin cytoskeleton targeting subunitparaneoplastic antigen-like protein 5paraneoplastic Ma antigen family member 5tumor antigen BJ-HCC-25
Modification date2018051920180519
UniProtAcc

Q6NYC8

Q96PV4

Ensembl transtripts involved in fusion geneENST00000488324, ENST00000399199, 
ENST00000274853, ENST00000498031, 
ENST00000444206, ENST00000438815, 
ENST00000552716, ENST00000491628, 
ENST00000435929, ENST00000412189, 
ENST00000548255, ENST00000493833, 
ENST00000438945, ENST00000455935, 
ENST00000551049, ENST00000472334, 
ENST00000451544, ENST00000437121, 
ENST00000551034, ENST00000465704, 
ENST00000383573, ENST00000400554, 
ENST00000550073, ENST00000492746, 
ENST00000449705, ENST00000443517, 
ENST00000551784, ENST00000487859, 
ENST00000435006, 
ENST00000361887, 
ENST00000439251, ENST00000452693, 
ENST00000535214, 
Fusion gene scores* DoF score4 X 6 X 3=721 X 1 X 1=1
# samples 61
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PPP1R18 [Title/Abstract] AND PNMA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX392220PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000488324ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000488324ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000488324ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000488324ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000399199ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000399199ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000399199ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000399199ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000274853ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000274853ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000274853ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000274853ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000498031ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000498031ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000498031ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000498031ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000444206ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000444206ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000444206ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000444206ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438815ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438815ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438815ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438815ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000552716ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000552716ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000552716ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000552716ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000491628ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000491628ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000491628ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000491628ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435929ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435929ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435929ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435929ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000412189ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000412189ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000412189ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000412189ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000548255ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000548255ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000548255ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000548255ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000493833ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000493833ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000493833ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000493833ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438945ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438945ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438945ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000438945ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000455935ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000455935ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000455935ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000455935ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551049ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551049ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551049ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551049ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000472334ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000472334ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000472334ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000472334ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000451544ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000451544ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000451544ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000451544ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000437121ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000437121ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000437121ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000437121ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551034ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551034ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551034ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551034ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000465704ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000465704ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000465704ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000465704ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000383573ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000383573ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000383573ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000383573ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000400554ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000400554ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000400554ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000400554ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000550073ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000550073ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000550073ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000550073ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000492746ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000492746ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000492746ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000492746ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000449705ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000449705ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000449705ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000449705ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000443517ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000443517ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000443517ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000443517ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551784ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551784ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551784ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000551784ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000487859ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000487859ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000487859ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000487859ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435006ENST00000361887PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435006ENST00000439251PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435006ENST00000452693PPP1R18chr6

1976835

+PNMA5chrX

152159705

+
intron-3CDSENST00000435006ENST00000535214PPP1R18chr6

1976835

+PNMA5chrX

152159705

+

Top

FusionProtFeatures for PPP1R18_PNMA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R18

Q6NYC8

PNMA5

Q96PV4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R18_PNMA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R18_PNMA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PPP1R18_PNMA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PPP1R18_PNMA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP1R18C0023893Liver Cirrhosis, Experimental1CTD_human