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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28348

FusionGeneSummary for PPP1R16A_SLC52A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R16A_SLC52A2
Fusion gene ID: 28348
HgeneTgene
Gene symbol

PPP1R16A

SLC52A2

Gene ID

84988

79581

Gene nameprotein phosphatase 1 regulatory subunit 16Asolute carrier family 52 member 2
SynonymsMYPT3BVVLS2|D15Ertd747e|GPCR41|GPR172A|PAR1|RFT3|RFVT2|hRFT3
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 16Amyosin phosphatase-targeting subunit 3protein phosphatase 1, regulatory (inhibitor) subunit 16Asolute carrier family 52, riboflavin transporter, member 2G protein-coupled receptor 172APERV-A receptor 1porcine endogenous retrovirus A receptor 1putative G-protein coupled receptor GPCR41riboflavin transporter 3solute carrier family 52 (riboflavi
Modification date2018051920180527
UniProtAcc

Q96I34

Q9HAB3

Ensembl transtripts involved in fusion geneENST00000292539, ENST00000529009, 
ENST00000435887, 		ENST00000530047, 
ENST00000527078, ENST00000402965, 
ENST00000532887, ENST00000329994, 
ENST00000526891, ENST00000540505, 
ENST00000526752, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 3=12
# samples 53
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP1R16A [Title/Abstract] AND SLC52A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC52A2

GO:0032218

riboflavin transport

20463145|27702554


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5KX-01APPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
TCGALDUCECTCGA-EO-A1Y7-01APPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000292539ENST00000530047PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-3CDSENST00000292539ENST00000527078PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-3CDSENST00000292539ENST00000402965PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-3CDSENST00000292539ENST00000532887PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-3CDSENST00000292539ENST00000329994PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-intronENST00000292539ENST00000526891PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-intronENST00000292539ENST00000540505PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
5UTR-intronENST00000292539ENST00000526752PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-3CDSENST00000529009ENST00000530047PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-3CDSENST00000529009ENST00000527078PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-3CDSENST00000529009ENST00000402965PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-3CDSENST00000529009ENST00000532887PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-3CDSENST00000529009ENST00000329994PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-intronENST00000529009ENST00000526891PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-intronENST00000529009ENST00000540505PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
3UTR-intronENST00000529009ENST00000526752PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-3CDSENST00000435887ENST00000530047PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-3CDSENST00000435887ENST00000527078PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-3CDSENST00000435887ENST00000402965PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-3CDSENST00000435887ENST00000532887PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-3CDSENST00000435887ENST00000329994PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-intronENST00000435887ENST00000526891PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-intronENST00000435887ENST00000540505PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-intronENST00000435887ENST00000526752PPP1R16Achr8

145715595

+SLC52A2chr8

145583775

+
intron-5UTRENST00000292539ENST00000530047PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000292539ENST00000527078PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000292539ENST00000402965PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000292539ENST00000532887PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000292539ENST00000329994PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-3UTRENST00000292539ENST00000526891PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000292539ENST00000540505PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000292539ENST00000526752PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000530047PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000527078PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000402965PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000532887PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000329994PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-3UTRENST00000529009ENST00000526891PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000540505PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000529009ENST00000526752PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000530047PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000527078PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000402965PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000532887PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000329994PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-3UTRENST00000435887ENST00000526891PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000540505PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+
intron-5UTRENST00000435887ENST00000526752PPP1R16Achr8

145703510

+SLC52A2chr8

145582844

+

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FusionProtFeatures for PPP1R16A_SLC52A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R16A

Q96I34

SLC52A2

Q9HAB3

Inhibits protein phosphatase 1 activity towardphosphorylase, myosin light chain and myosin substrates.{ECO:0000250}. Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is stronglyinhibited by riboflavin analogs, such as lumiflavin. Weaklyinhibited by flavin adenine dinucleotide (FAD) and flavinmononucleotide (FMN). In case of infection by retroviruses, actsas a cell receptor to retroviral envelopes similar to the porcineendogenous retrovirus (PERV-A). {ECO:0000269|PubMed:12740431,ECO:0000269|PubMed:19307586, ECO:0000269|PubMed:20463145,ECO:0000269|PubMed:22864630, ECO:0000269|PubMed:23243084,ECO:0000269|PubMed:24253200, ECO:0000269|PubMed:27702554}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R16A_SLC52A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R16A_SLC52A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R16ATRIP6, CDH24, DDX27, FSD1, IDO1, PBDC1, PAPSS1, PHPT1, RGMA, PUF60, TXNRD1, HGS, PPP1CA, PPP1CC, AES, PPP1CB, TPP2, PPP1R16A, RABGGTB, TFIP11, LZTS2SLC52A2ADRB2, CDC23, UPK1A, SPPL2B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R16A_SLC52A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R16A_SLC52A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC52A2C3553538BROWN-VIALETTO-VAN LAERE SYNDROME 24UNIPROT