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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28346

FusionGeneSummary for PPP1R16A_CLDN4

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R16A_CLDN4
Fusion gene ID: 28346
HgeneTgene
Gene symbol

PPP1R16A

CLDN4

Gene ID

84988

1364

Gene nameprotein phosphatase 1 regulatory subunit 16Aclaudin 4
SynonymsMYPT3CPE-R|CPER|CPETR|CPETR1|WBSCR8|hCPE-R
Cytomap

8q24.3

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 16Amyosin phosphatase-targeting subunit 3protein phosphatase 1, regulatory (inhibitor) subunit 16Aclaudin-4CPE-receptorClostridium perfringens enterotoxin receptor 1Williams-Beuren syndrome chromosomal region 8 protein
Modification date2018051920180527
UniProtAcc

Q96I34

O14493

Ensembl transtripts involved in fusion geneENST00000292539, ENST00000529009, 
ENST00000435887, 
ENST00000466411, 
ENST00000435050, ENST00000431918, 
ENST00000340958, 
Fusion gene scores* DoF score4 X 4 X 4=646 X 4 X 2=48
# samples 57
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP1R16A [Title/Abstract] AND CLDN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7748-01APPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000292539ENST00000466411PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-5UTRENST00000292539ENST00000435050PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-5UTRENST00000292539ENST00000431918PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-5UTRENST00000292539ENST00000340958PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
intron-intronENST00000529009ENST00000466411PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
intron-5UTRENST00000529009ENST00000435050PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
intron-5UTRENST00000529009ENST00000431918PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
intron-5UTRENST00000529009ENST00000340958PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-intronENST00000435887ENST00000466411PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-5UTRENST00000435887ENST00000435050PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-5UTRENST00000435887ENST00000431918PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+
5CDS-5UTRENST00000435887ENST00000340958PPP1R16Achr8

145727504

+CLDN4chr7

73245329

+

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FusionProtFeatures for PPP1R16A_CLDN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R16A

Q96I34

CLDN4

O14493

Inhibits protein phosphatase 1 activity towardphosphorylase, myosin light chain and myosin substrates.{ECO:0000250}. Channel-forming tight junction protein that mediatesparacellular chloride transport in the kidney. Plays a criticalrole in the paracellular reabsorption of filtered chloride in thekidney collecting ducts. Claudins play a major role in tightjunction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity.{ECO:0000250|UniProtKB:O35054}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R16A_CLDN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R16A_CLDN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R16ATRIP6, CDH24, DDX27, FSD1, IDO1, PBDC1, PAPSS1, PHPT1, RGMA, PUF60, TXNRD1, HGS, PPP1CA, PPP1CC, AES, PPP1CB, TPP2, PPP1R16A, RABGGTB, TFIP11, LZTS2CLDN4TJP1, SHBG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R16A_CLDN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R16A_CLDN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLDN4C0027643Neoplasm Recurrence, Local1CTD_human
TgeneCLDN4C0032460Polycystic Ovary Syndrome1CTD_human
TgeneCLDN4C1134719Invasive Ductal Breast Carcinoma1CTD_human
TgeneCLDN4C1458155Mammary Neoplasms1CTD_human