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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28339

FusionGeneSummary for PPP1R15A_EMP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R15A_EMP3
Fusion gene ID: 28339
HgeneTgene
Gene symbol

PPP1R15A

EMP3

Gene ID

23645

2014

Gene nameprotein phosphatase 1 regulatory subunit 15Aepithelial membrane protein 3
SynonymsGADD34YMP
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 15Agrowth arrest and DNA damage-inducible protein GADD34growth arrest and DNA-damage-inducible 34myeloid differentiation primary response protein MyD116 homologprotein phosphatase 1, regulatory (inhibitor) subuepithelial membrane protein 3EMP-3HNMP-1hematopoietic neural membrane protein 1
Modification date2018052320180523
UniProtAcc

O75807

P54852

Ensembl transtripts involved in fusion geneENST00000200453, ENST00000270221, 
ENST00000596315, ENST00000597279, 
Fusion gene scores* DoF score5 X 5 X 2=502 X 3 X 2=12
# samples 72
** MAII scorelog2(7/50*10)=0.485426827170242
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP1R15A [Title/Abstract] AND EMP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R15A

GO:0032515

negative regulation of phosphoprotein phosphatase activity

11564868

HgenePPP1R15A

GO:0032516

positive regulation of phosphoprotein phosphatase activity

11564868

HgenePPP1R15A

GO:0034976

response to endoplasmic reticulum stress

12556489

HgenePPP1R15A

GO:0035308

negative regulation of protein dephosphorylation

11564868

HgenePPP1R15A

GO:0036496

regulation of translational initiation by eIF2 alpha dephosphorylation

12556489

HgenePPP1R15A

GO:1902310

positive regulation of peptidyl-serine dephosphorylation

11564868|12556489|21518769

HgenePPP1R15A

GO:1903917

positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

21518769

TgeneEMP3

GO:0008219

cell death

12107182

TgeneEMP3

GO:0032060

bleb assembly

12107182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-VS-A9UT-01APPP1R15Achr19

49378155

+EMP3chr19

48830087

+
TCGALDCESCTCGA-VS-A9UT-01APPP1R15Achr19

49378155

+EMP3chr19

48825071

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000200453ENST00000270221PPP1R15Achr19

49378155

+EMP3chr19

48830087

+
5CDS-intronENST00000200453ENST00000596315PPP1R15Achr19

49378155

+EMP3chr19

48830087

+
5CDS-5UTRENST00000200453ENST00000597279PPP1R15Achr19

49378155

+EMP3chr19

48830087

+
5CDS-intronENST00000200453ENST00000270221PPP1R15Achr19

49378155

+EMP3chr19

48825071

+
5CDS-intronENST00000200453ENST00000596315PPP1R15Achr19

49378155

+EMP3chr19

48825071

+
5CDS-intronENST00000200453ENST00000597279PPP1R15Achr19

49378155

+EMP3chr19

48825071

+

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FusionProtFeatures for PPP1R15A_EMP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R15A

O75807

EMP3

P54852

Recruits the serine/threonine-protein phosphatase PP1 todephosphorylate the translation initiation factor eIF-2A/EIF2S1,thereby reversing the shut-off of protein synthesis initiated bystress-inducible kinases and facilitating recovery of cells fromstress. Down-regulates the TGF-beta signaling pathway by promotingdephosphorylation of TGFB1 by PP1. May promote apoptosis byinducing TP53 phosphorylation on 'Ser-15'.{ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489,ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519,ECO:0000269|PubMed:8139541}. Probably involved in cell proliferation and cell-cellinteractions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R15A_EMP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R15A_EMP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R15AKMT2A, BAG1, HSPA8, PPP1CA, SMARCB1, PPP1CB, PPP1CC, BCAR1, EIF2S1, TSN, LYN, HABP4, CUEDC2, IKBKB, RAD21, CUL3, COPS5, CAND1, SMAD7, ZNF512B, CTBP2, PPP1R1A, PLEKHA1, MINK1, ZNF92, POP4, MUM1, BBXEMP3CREM, EDA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R15A_EMP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R15A_EMP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEMP3C0033578Prostatic Neoplasms1CTD_human