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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2829

FusionGeneSummary for ARPP21_FRMD4A

check button Fusion gene summary
Fusion gene informationFusion gene name: ARPP21_FRMD4A
Fusion gene ID: 2829
HgeneTgene
Gene symbol

ARPP21

FRMD4A

Gene ID

10777

55691

Gene namecAMP regulated phosphoprotein 21FERM domain containing 4A
SynonymsARPP-21|R3HDM3|RCS|TARPPCCAFCA|FRMD4|bA295P9.4
Cytomap

3p22.3

10p13

Type of geneprotein-codingprotein-coding
DescriptioncAMP-regulated phosphoprotein 21R3H domain containing 3cAMP regulated phosphoprotein 21kDacyclic AMP-regulated phosphoprotein, 21 kDthymocyte cAMP-regulated phosphoproteinFERM domain-containing protein 4AFERM domain containing 4
Modification date2018051920180519
UniProtAcc

Q9UBL0

Q9P2Q2

Ensembl transtripts involved in fusion geneENST00000458225, ENST00000337271, 
ENST00000444190, ENST00000187397, 
ENST00000417925, ENST00000428373, 
ENST00000427542, ENST00000474696, 
ENST00000412048, ENST00000396482, 
ENST00000432682, ENST00000396481, 
ENST00000441454, ENST00000436702, 
ENST00000438071, ENST00000476052, 
ENST00000358621, ENST00000357447, 
ENST00000378503, ENST00000342409, 
ENST00000493380, ENST00000475141, 
ENST00000492155, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 7 X 6=378
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARPP21 [Title/Abstract] AND FRMD4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-S9-A6U6-01AARPP21chr3

35725307

+FRMD4Achr10

14125812

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000458225ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000458225ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000458225ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000458225ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000458225ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000458225ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000458225ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000337271ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000337271ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000337271ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000337271ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000337271ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000337271ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000337271ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000444190ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000444190ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000444190ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000444190ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000444190ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000444190ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000444190ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000187397ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000187397ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000187397ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000187397ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000187397ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000187397ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000187397ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000417925ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000417925ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000417925ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000417925ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000417925ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000417925ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000417925ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000428373ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000428373ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000428373ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000428373ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000428373ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000428373ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000428373ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000427542ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000427542ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000427542ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000427542ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000427542ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000427542ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000427542ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000474696ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000474696ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000474696ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000474696ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000474696ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000474696ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000474696ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000412048ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000412048ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000412048ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000412048ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000412048ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000412048ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000412048ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396482ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396482ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396482ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396482ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000396482ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396482ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396482ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000432682ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000432682ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000432682ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000432682ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000432682ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000432682ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000432682ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396481ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396481ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396481ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396481ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000396481ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396481ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000396481ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000441454ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000441454ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000441454ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000441454ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000441454ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000441454ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000441454ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000436702ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000436702ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000436702ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000436702ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000436702ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000436702ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000436702ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000438071ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000438071ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000438071ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000438071ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-3UTRENST00000438071ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000438071ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
5CDS-intronENST00000438071ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-intronENST00000476052ENST00000358621ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-intronENST00000476052ENST00000357447ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-intronENST00000476052ENST00000378503ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-intronENST00000476052ENST00000342409ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-3UTRENST00000476052ENST00000493380ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-intronENST00000476052ENST00000475141ARPP21chr3

35725307

+FRMD4Achr10

14125812

-
intron-intronENST00000476052ENST00000492155ARPP21chr3

35725307

+FRMD4Achr10

14125812

-

Top

FusionProtFeatures for ARPP21_FRMD4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARPP21

Q9UBL0

FRMD4A

Q9P2Q2

Isoform 2 may act as a competitive inhibitor ofcalmodulin-dependent enzymes such as calcineurin in neurons.{ECO:0000250}. Scaffolding protein that regulates epithelial cellpolarity by connecting ARF6 activation with the PAR3 complex (Bysimilarity). Plays a redundant role with FRMD4B in epithelialpolarization (By similarity). May regulate MAPT secretion byactivating ARF6-signaling (PubMed:27044754).{ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARPP21_FRMD4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ARPP21_FRMD4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARPP21TERF1, TERF2IP, TP53FRMD4AHNRNPA1, TRAF3IP1, YEATS4, WDR83


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARPP21_FRMD4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARPP21_FRMD4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFRMD4AC0236969Substance-Related Disorders1CTD_human