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Fusion gene ID: 28241 |
FusionGeneSummary for PPM1G_FOXO3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPM1G_FOXO3 | Fusion gene ID: 28241 | Hgene | Tgene | Gene symbol | PPM1G | FOXO3 | Gene ID | 5496 | 2309 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1G | forkhead box O3 | |
| Synonyms | PP2CG|PP2CGAMMA|PPP2CG | AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A | |
| Cytomap | 2p23.3 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1GPP2C-gammaprotein phosphatase 1Cprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoformprotein phosphatase 2, catalytic subunit, gamma isoformprotein phosphatase 2C gamma isoformprotein phosphatase 2C isoform g | forkhead box protein O3forkhead box O3Aforkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | O15355 | O43524 | |
| Ensembl transtripts involved in fusion gene | ENST00000344034, ENST00000350803, | ENST00000343882, ENST00000406360, ENST00000540898, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 4 X 4 X 2=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPM1G [Title/Abstract] AND FOXO3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPM1G | GO:0035970 | peptidyl-threonine dephosphorylation | 20801214 |
| Tgene | FOXO3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20371612 |
| Tgene | FOXO3 | GO:0006417 | regulation of translation | 21329882 |
| Tgene | FOXO3 | GO:0043065 | positive regulation of apoptotic process | 20371612 |
| Tgene | FOXO3 | GO:0045648 | positive regulation of erythrocyte differentiation | 14734530 |
| Tgene | FOXO3 | GO:0045893 | positive regulation of transcription, DNA-templated | 10102273|15084260 |
| Tgene | FOXO3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10102273|14734530 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE149668 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000344034 | ENST00000343882 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
| intron-intron | ENST00000344034 | ENST00000406360 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
| intron-intron | ENST00000344034 | ENST00000540898 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
| intron-intron | ENST00000350803 | ENST00000343882 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
| intron-intron | ENST00000350803 | ENST00000406360 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
| intron-intron | ENST00000350803 | ENST00000540898 | PPM1G | chr2 | 27604640 | + | FOXO3 | chr6 | 108915984 | + |
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FusionProtFeatures for PPM1G_FOXO3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPM1G | FOXO3 |
| Transcriptional activator which triggers apoptosis inthe absence of survival factors, including neuronal cell deathupon oxidative stress (PubMed:10102273, PubMed:16751106).Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'(PubMed:21329882). Participates in post-transcriptional regulationof MYC: following phosphorylation by MAPKAPK5, promotes inductionof miR-34b and miR-34c expression, 2 post-transcriptionalregulators of MYC that bind to the 3'UTR of MYC transcript andprevent its translation (PubMed:21329882). In response tometabolic stress, translocates into the mitochondria where itpromotes mtDNA transcription (PubMed:23283301).{ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106,ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPM1G_FOXO3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPM1G_FOXO3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPM1G_FOXO3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1G_FOXO3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPM1G | C0001956 | alcohol use disorder | 1 | PSYGENET |
| Tgene | FOXO3 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
| Tgene | FOXO3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | FOXO3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | FOXO3 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | FOXO3 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| Tgene | FOXO3 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | FOXO3 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
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