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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28228

FusionGeneSummary for PPM1B_SRBD1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPM1B_SRBD1
Fusion gene ID: 28228
HgeneTgene
Gene symbol

PPM1B

SRBD1

Gene ID

5495

55133

Gene nameprotein phosphatase, Mg2+/Mn2+ dependent 1BS1 RNA binding domain 1
SynonymsPP2C-beta|PP2C-beta-X|PP2CB|PP2CBETA|PPC2BETAX-
Cytomap

2p21

2p21

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1BSer/Thr protein phosphatase type 2C beta 2 isoformprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoformprotein phosphatase 2C-like proteinS1 RNA-binding domain-containing protein 1H_NH0576F01.1WUGSC:H_NH0576F01.1
Modification date2018051920180523
UniProtAcc

O75688

Q8N5C6

Ensembl transtripts involved in fusion geneENST00000409895, ENST00000409432, 
ENST00000282412, ENST00000378551, 
ENST00000378540, ENST00000345249, 
ENST00000263736, ENST00000535761, 
ENST00000490133, 
Fusion gene scores* DoF score4 X 2 X 4=323 X 2 X 3=18
# samples 43
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPM1B [Title/Abstract] AND SRBD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPM1B

GO:0035970

peptidyl-threonine dephosphorylation

20801214


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-52-7809-01APPM1Bchr2

44396413

+SRBD1chr2

45647033

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000409895ENST00000263736PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000409895ENST00000535761PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-5UTRENST00000409895ENST00000490133PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000409432ENST00000263736PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000409432ENST00000535761PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-5UTRENST00000409432ENST00000490133PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000282412ENST00000263736PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000282412ENST00000535761PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-5UTRENST00000282412ENST00000490133PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000378551ENST00000263736PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000378551ENST00000535761PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-5UTRENST00000378551ENST00000490133PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
3UTR-3CDSENST00000378540ENST00000263736PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
3UTR-3CDSENST00000378540ENST00000535761PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
3UTR-5UTRENST00000378540ENST00000490133PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000345249ENST00000263736PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-3CDSENST00000345249ENST00000535761PPM1Bchr2

44396413

+SRBD1chr2

45647033

-
5UTR-5UTRENST00000345249ENST00000490133PPM1Bchr2

44396413

+SRBD1chr2

45647033

-

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FusionProtFeatures for PPM1B_SRBD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPM1B

O75688

SRBD1

Q8N5C6

Enzyme with a broad specificity. Dephosphorylates CDK2and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. InhibitsTBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating andinactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133,ECO:0000269|PubMed:22750291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPM1B_SRBD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPM1B_SRBD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPM1BRASGRP1, KRT18, VIL1, S100A8, GSN, VCP, PABPC4, ANXA1, ANXA2, IKBKG, IKBKB, CHUK, PPP2CA, CDK2, CDK6, MAP3K7, ISG15, VHL, TLE4, VAV2, ARRB1, ARRB2, FBXO6, UBL7, EIF4A3, MAGOH, YWHAE, NOS2, PAN2, GCH1, ECHS1, AURKB, PPARG, NR1I3, PPM1A, FAM63B, FNTB, CASK, CDK1, LRRK1, MAP4K5, NAA10, ABL1, CDK13, CSNK1D, CSNK1E, DDX53, GAK, MAPK8, PAK4, PKN2, PRKCI, STK40, HERC2, XPO1, HIST1H3E, SKI, ACTA1, HIST1H2AE, HSPA2, SPTAN1, SPTBN1, VIM, KIF15, KARS, HEATR5A, FEZ2, BPGM, THUMPD3, CERKL, C9orf142, PVR, HIP1R, C1orf87, AATK, ERBB4, EGFR, ERBB3, KDR, RYK, ROR1, ROR2, PTK7, CYLD, COQ2, COX15, PARK7, SOAT1, SOD1, VDAC1, DCAF4L2SRBD1USP45, SART3, ELAVL1, TAOK1, CBX7, TARDBP, HECW2, RPA3, RPA2, RPA1, NXF1, NTRK1, HIST1H2BG, HIST1H3A, CEP89, HNRNPU, FBXW7, RCAN1, GSK3A, TRIM44, ARHGAP22, MECP2, CROCC, PPP3CC, RRP8, ZC3HC1, RPL18A, PPP3R1, ARIH1, ZBTB48, CCDC59


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPM1B_SRBD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPM1B_SRBD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPM1BC0151744Myocardial Ischemia1CTD_human
HgenePPM1BC1848030Hypotonia-Cystinuria Syndrome1CTD_human;ORPHANET