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Fusion gene ID: 28223 |
FusionGeneSummary for PPM1A_ADCK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPM1A_ADCK4 | Fusion gene ID: 28223 | Hgene | Tgene | Gene symbol | PPM1A | ADCK4 | Gene ID | 5494 | 79934 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1A | coenzyme Q8B | |
| Synonyms | PP2C-ALPHA|PP2CA|PP2Calpha | ADCK4|NPHS9 | |
| Cytomap | 14q23.1 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1Aprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | atypical kinase COQ8B, mitochondrialaarF domain containing kinase 4aarF domain-containing protein kinase 4coenzyme Q protein 8B | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P35813 | ||
| Ensembl transtripts involved in fusion gene | ENST00000325642, ENST00000529574, ENST00000395076, ENST00000325658, | ENST00000324464, ENST00000450541, ENST00000243583, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPM1A [Title/Abstract] AND ADCK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPM1A | GO:0010991 | negative regulation of SMAD protein complex assembly | 16751101 |
| Hgene | PPM1A | GO:0016055 | Wnt signaling pathway | 10644691 |
| Hgene | PPM1A | GO:0016311 | dephosphorylation | 10644691 |
| Hgene | PPM1A | GO:0030177 | positive regulation of Wnt signaling pathway | 10644691 |
| Hgene | PPM1A | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 16751101 |
| Hgene | PPM1A | GO:0035970 | peptidyl-threonine dephosphorylation | 11559703|20801214 |
| Hgene | PPM1A | GO:0045893 | positive regulation of transcription, DNA-templated | 10644691 |
| Tgene | ADCK4 | GO:0006468 | protein phosphorylation | 27499294 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-P5-A5F2-01A | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000325642 | ENST00000324464 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| intron-3CDS | ENST00000325642 | ENST00000450541 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| intron-3CDS | ENST00000325642 | ENST00000243583 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| intron-3CDS | ENST00000529574 | ENST00000324464 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| intron-3CDS | ENST00000529574 | ENST00000450541 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| intron-3CDS | ENST00000529574 | ENST00000243583 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| 5UTR-3CDS | ENST00000395076 | ENST00000324464 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| 5UTR-3CDS | ENST00000395076 | ENST00000450541 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| 5UTR-3CDS | ENST00000395076 | ENST00000243583 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| 5UTR-3CDS | ENST00000325658 | ENST00000324464 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| 5UTR-3CDS | ENST00000325658 | ENST00000450541 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
| 5UTR-3CDS | ENST00000325658 | ENST00000243583 | PPM1A | chr14 | 60716395 | + | ADCK4 | chr19 | 41220302 | - |
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FusionProtFeatures for PPM1A_ADCK4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPM1A | ADCK4 |
| Enzyme with a broad specificity. Negatively regulatesTGF-beta signaling through dephosphorylating SMAD2 and SMAD3,resulting in their dissociation from SMAD4, nuclear export of theSMADs and termination of the TGF-beta-mediated signaling.Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in thetermination of TNF-alpha-mediated NF-kappa-B activation throughdephosphorylating and inactivating IKBKB/IKKB.{ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPM1A_ADCK4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPM1A_ADCK4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPM1A | LXN, GRM3, ARRB1, ARRB2, SMAD1, SMURF1, FGFR2, NR4A1, HSPB1, RPLP0, ASB2, DCP1B, HSFY1, PRKAA1, FBXW11, CER1, PRSS22, ADAMTS12, CHST10, VWA9, INPPL1, PPM1B, RTEL1, GDF3, RNASE13, CHEK1, MAP4K5, NAA10, MAPK9, PKN1, PRKCI, HNRNPD, XRCC5, TOR1AIP1, ACTR5, PIGS, NEDD1, AKT1, EGFR, IGF1R, INSR, BCKDK, FANCI, GCN1L1, HSD17B4, HSDL2, IWS1, LETM1, PAK4, SLC25A5, SLFN11, UGGT1, DUSP12, DUSP22, HAO2, CERKL, TECPR2, QARS, INSL6, PDDC1, HIP1R, CCL22, ZDHHC11, UBE3D, ALDH3B1, FBXL14, MTERF2, LMTK2, AATK, ERBB4, ERBB2, ERBB3, KDR, ROR2, ALK, PTK7, PAK1, PAK2, CDC42BPA, CDC42BPB, PRKCA, CYLD, COQ2, SOAT1, SOD1, VDAC1 | ADCK4 | CD27, P2RX4, ADCK4, COQ5, STOML2, PMPCA, PMPCB, COQ9, PITRM1, COQ6, ADCK3, COQ7, CHCHD2, CLPB, ATP5O, ATP5H, ATP5F1, POLDIP2, ATP5E, COQ3, ERAL1, GOLPH3, ATP5C1, C1QBP, TIMM44, TIMM50, CD70, VIPR2, SLC2A12, C5AR2, APLNR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPM1A_ADCK4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1A_ADCK4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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