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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28211

FusionGeneSummary for PPIL3_NEMF

check button Fusion gene summary
Fusion gene informationFusion gene name: PPIL3_NEMF
Fusion gene ID: 28211
HgeneTgene
Gene symbol

PPIL3

NEMF

Gene ID

53938

9147

Gene namepeptidylprolyl isomerase like 3nuclear export mediator factor
SynonymsCYPJNY-CO-1|SDCCAG1
Cytomap

2q33.1

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase-like 3PPIasePPIase-like protein 3cyclophilin Jcyclophilin-like protein 3cyclophilin-like protein PPIL3peptidylprolyl cis-trans isomerase-like protein 3peptidylprolyl isomerase (cyclophilin)-like 3rotamase PPIL3nuclear export mediator factor NEMFantigen NY-CO-1serologically defined colon cancer antigen 1
Modification date2018052320180523
UniProtAcc

Q9H2H8

O60524

Ensembl transtripts involved in fusion geneENST00000286175, ENST00000392283, 
ENST00000465823, ENST00000409361, 
ENST00000409449, 		ENST00000298310, 
ENST00000382135, ENST00000545773, 
ENST00000556925, ENST00000546046, 
ENST00000556672, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 11 X 2=176
# samples 213
** MAII scorelog2(2/4*10)=2.32192809488736log2(13/176*10)=-0.437063805608843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPIL3 [Title/Abstract] AND NEMF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK027315PPIL3chr2

201736043

-NEMFchr14

50065705

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000286175ENST00000298310PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000286175ENST00000382135PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000286175ENST00000545773PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000286175ENST00000556925PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000286175ENST00000546046PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000286175ENST00000556672PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000392283ENST00000298310PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000392283ENST00000382135PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000392283ENST00000545773PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000392283ENST00000556925PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000392283ENST00000546046PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000392283ENST00000556672PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000465823ENST00000298310PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000465823ENST00000382135PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000465823ENST00000545773PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000465823ENST00000556925PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000465823ENST00000546046PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000465823ENST00000556672PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409361ENST00000298310PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409361ENST00000382135PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409361ENST00000545773PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409361ENST00000556925PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409361ENST00000546046PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409361ENST00000556672PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409449ENST00000298310PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409449ENST00000382135PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409449ENST00000545773PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409449ENST00000556925PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409449ENST00000546046PPIL3chr2

201736043

-NEMFchr14

50065705

+
intron-intronENST00000409449ENST00000556672PPIL3chr2

201736043

-NEMFchr14

50065705

+

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FusionProtFeatures for PPIL3_NEMF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPIL3

Q9H2H8

NEMF

O60524

PPIases accelerate the folding of proteins. It catalyzesthe cis-trans isomerization of proline imidic peptide bonds inoligopeptides. May be involved in pre-mRNA splicing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPIL3_NEMF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPIL3_NEMF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPIL3_NEMF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPIL3_NEMF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource