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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28204

FusionGeneSummary for PPIG_SRSF5

check button Fusion gene summary
Fusion gene informationFusion gene name: PPIG_SRSF5
Fusion gene ID: 28204
HgeneTgene
Gene symbol

PPIG

SRSF5

Gene ID

9360

6430

Gene namepeptidylprolyl isomerase Gserine and arginine rich splicing factor 5
SynonymsCARS-Cyp|CYP|SCAF10|SRCypHRS|SFRS5|SRP40
Cytomap

2q31.1

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase Gserine/arginine-rich splicing factor 5SR splicing factor 5delayed-early protein HRSpre-mRNA-splicing factor SRP40splicing factor, arginine/serine-rich 5
Modification date2018052320180523
UniProtAcc

Q13427

Q13243

Ensembl transtripts involved in fusion geneENST00000260970, ENST00000409714, 
ENST00000462903, ENST00000448752, 
ENST00000482772, 		ENST00000553521, 
ENST00000394366, ENST00000553548, 
ENST00000557154, ENST00000451983, 
ENST00000553635, ENST00000556587, 
ENST00000555349, ENST00000554021, 
Fusion gene scores* DoF score9 X 11 X 6=5944 X 4 X 1=16
# samples 144
** MAII scorelog2(14/594*10)=-2.0850361038558
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPIG [Title/Abstract] AND SRSF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPIG

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF095300PPIGchr2

170471217

+SRSF5chr14

70235360

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260970ENST00000553521PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000260970ENST00000394366PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000260970ENST00000553548PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000260970ENST00000557154PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000260970ENST00000451983PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000260970ENST00000553635PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000260970ENST00000556587PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000260970ENST00000555349PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000260970ENST00000554021PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000409714ENST00000553521PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000409714ENST00000394366PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000409714ENST00000553548PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000409714ENST00000557154PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000409714ENST00000451983PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000409714ENST00000553635PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000409714ENST00000556587PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000409714ENST00000555349PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000409714ENST00000554021PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000462903ENST00000553521PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000462903ENST00000394366PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000462903ENST00000553548PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000462903ENST00000557154PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000462903ENST00000451983PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000462903ENST00000553635PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000462903ENST00000556587PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000462903ENST00000555349PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000462903ENST00000554021PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000448752ENST00000553521PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000448752ENST00000394366PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000448752ENST00000553548PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000448752ENST00000557154PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000448752ENST00000451983PPIGchr2

170471217

+SRSF5chr14

70235360

+
Frame-shiftENST00000448752ENST00000553635PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000448752ENST00000556587PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000448752ENST00000555349PPIGchr2

170471217

+SRSF5chr14

70235360

+
5CDS-3UTRENST00000448752ENST00000554021PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3CDSENST00000482772ENST00000553521PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3CDSENST00000482772ENST00000394366PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3CDSENST00000482772ENST00000553548PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3CDSENST00000482772ENST00000557154PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3CDSENST00000482772ENST00000451983PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3CDSENST00000482772ENST00000553635PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3UTRENST00000482772ENST00000556587PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3UTRENST00000482772ENST00000555349PPIGchr2

170471217

+SRSF5chr14

70235360

+
intron-3UTRENST00000482772ENST00000554021PPIGchr2

170471217

+SRSF5chr14

70235360

+

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FusionProtFeatures for PPIG_SRSF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPIG

Q13427

SRSF5

Q13243

PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be implicated in thefolding, transport, and assembly of proteins. May play animportant role in the regulation of pre-mRNA splicing.{ECO:0000269|PubMed:20676357}. Plays a role in constitutive splicing and can modulatethe selection of alternative splice sites.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPIG_SRSF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPIG_SRSF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPIG_SRSF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPIG_SRSF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSRSF5C0023895Liver diseases1CTD_human
TgeneSRSF5C0235032Neurotoxicity Syndromes1CTD_human