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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28201

FusionGeneSummary for PPIG_PPIG

check button Fusion gene summary
Fusion gene informationFusion gene name: PPIG_PPIG
Fusion gene ID: 28201
HgeneTgene
Gene symbol

PPIG

PPIG

Gene ID

9360

9360

Gene namepeptidylprolyl isomerase Gpeptidylprolyl isomerase G
SynonymsCARS-Cyp|CYP|SCAF10|SRCypCARS-Cyp|CYP|SCAF10|SRCyp
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase Gpeptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G
Modification date2018052320180523
UniProtAcc

Q13427

Q13427

Ensembl transtripts involved in fusion geneENST00000260970, ENST00000409714, 
ENST00000462903, ENST00000448752, 
ENST00000482772, 		ENST00000260970, 
ENST00000409714, ENST00000462903, 
ENST00000448752, ENST00000482772, 
Fusion gene scores* DoF score9 X 11 X 6=5944 X 5 X 1=20
# samples 147
** MAII scorelog2(14/594*10)=-2.0850361038558
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/20*10)=1.8073549220576
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPIG [Title/Abstract] AND PPIG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPIG

GO:0000413

protein peptidyl-prolyl isomerization

20676357

TgenePPIG

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU616569PPIGchr2

170492946

-PPIGchr2

170493697

-
ChiTaRS3.1CA428637PPIGchr2

170492946

-PPIGchr2

170493697

-
ChiTaRS3.1BU622289PPIGchr2

170492946

-PPIGchr2

170493697

-
ChiTaRS3.1CN282143PPIGchr2

170493419

+PPIGchr2

170465243

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260970ENST00000260970PPIGchr2

170492946

-PPIGchr2

170493697

-
In-frameENST00000260970ENST00000409714PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000260970ENST00000462903PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000260970ENST00000448752PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000260970ENST00000482772PPIGchr2

170492946

-PPIGchr2

170493697

-
In-frameENST00000409714ENST00000260970PPIGchr2

170492946

-PPIGchr2

170493697

-
Frame-shiftENST00000409714ENST00000409714PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000409714ENST00000462903PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000409714ENST00000448752PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000409714ENST00000482772PPIGchr2

170492946

-PPIGchr2

170493697

-
intron-3CDSENST00000462903ENST00000260970PPIGchr2

170492946

-PPIGchr2

170493697

-
intron-3CDSENST00000462903ENST00000409714PPIGchr2

170492946

-PPIGchr2

170493697

-
intron-intronENST00000462903ENST00000462903PPIGchr2

170492946

-PPIGchr2

170493697

-
intron-intronENST00000462903ENST00000448752PPIGchr2

170492946

-PPIGchr2

170493697

-
intron-intronENST00000462903ENST00000482772PPIGchr2

170492946

-PPIGchr2

170493697

-
In-frameENST00000448752ENST00000260970PPIGchr2

170492946

-PPIGchr2

170493697

-
Frame-shiftENST00000448752ENST00000409714PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000448752ENST00000462903PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000448752ENST00000448752PPIGchr2

170492946

-PPIGchr2

170493697

-
5CDS-intronENST00000448752ENST00000482772PPIGchr2

170492946

-PPIGchr2

170493697

-
3UTR-3CDSENST00000482772ENST00000260970PPIGchr2

170492946

-PPIGchr2

170493697

-
3UTR-3CDSENST00000482772ENST00000409714PPIGchr2

170492946

-PPIGchr2

170493697

-
3UTR-intronENST00000482772ENST00000462903PPIGchr2

170492946

-PPIGchr2

170493697

-
3UTR-intronENST00000482772ENST00000448752PPIGchr2

170492946

-PPIGchr2

170493697

-
3UTR-intronENST00000482772ENST00000482772PPIGchr2

170492946

-PPIGchr2

170493697

-
In-frameENST00000260970ENST00000260970PPIGchr2

170493419

+PPIGchr2

170465243

+
In-frameENST00000260970ENST00000409714PPIGchr2

170493419

+PPIGchr2

170465243

+
In-frameENST00000260970ENST00000462903PPIGchr2

170493419

+PPIGchr2

170465243

+
In-frameENST00000260970ENST00000448752PPIGchr2

170493419

+PPIGchr2

170465243

+
5CDS-intronENST00000260970ENST00000482772PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000409714ENST00000260970PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000409714ENST00000409714PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000409714ENST00000462903PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000409714ENST00000448752PPIGchr2

170493419

+PPIGchr2

170465243

+
5CDS-intronENST00000409714ENST00000482772PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000462903ENST00000260970PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000462903ENST00000409714PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000462903ENST00000462903PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000462903ENST00000448752PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-intronENST00000462903ENST00000482772PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000448752ENST00000260970PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000448752ENST00000409714PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000448752ENST00000462903PPIGchr2

170493419

+PPIGchr2

170465243

+
Frame-shiftENST00000448752ENST00000448752PPIGchr2

170493419

+PPIGchr2

170465243

+
5CDS-intronENST00000448752ENST00000482772PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000482772ENST00000260970PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000482772ENST00000409714PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000482772ENST00000462903PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-3CDSENST00000482772ENST00000448752PPIGchr2

170493419

+PPIGchr2

170465243

+
intron-intronENST00000482772ENST00000482772PPIGchr2

170493419

+PPIGchr2

170465243

+

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FusionProtFeatures for PPIG_PPIG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPIG

Q13427

PPIG

Q13427

PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be implicated in thefolding, transport, and assembly of proteins. May play animportant role in the regulation of pre-mRNA splicing.{ECO:0000269|PubMed:20676357}. PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be implicated in thefolding, transport, and assembly of proteins. May play animportant role in the regulation of pre-mRNA splicing.{ECO:0000269|PubMed:20676357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPIG_PPIG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPIG_PPIG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPIG_PPIG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPIG_PPIG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource