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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28195

FusionGeneSummary for PPIF_REEP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPIF_REEP3
Fusion gene ID: 28195
HgeneTgene
Gene symbol

PPIF

REEP3

Gene ID

10105

221035

Gene namepeptidylprolyl isomerase Freceptor accessory protein 3
SynonymsCYP3|CyP-M|Cyp-D|CypDC10orf74|Yip2b
Cytomap

10q22.3

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase F, mitochondrialPPIase Fcyclophilin 3cyclophilin Dcyclophilin Fmitochondrial cyclophilinpeptidyl-prolyl cis-trans isomerase, mitochondrialrotamase Freceptor expression-enhancing protein 3
Modification date2018052320180519
UniProtAcc

P30405

Q6NUK4

Ensembl transtripts involved in fusion geneENST00000394579, ENST00000225174, 
ENST00000492149, 
ENST00000298249, 
ENST00000373758, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 2 X 3=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPIF [Title/Abstract] AND REEP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPIF

GO:0000413

protein peptidyl-prolyl isomerization

20676357

HgenePPIF

GO:0043066

negative regulation of apoptotic process

19228691

HgenePPIF

GO:0090201

negative regulation of release of cytochrome c from mitochondria

19228691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A0AJ-01APPIFchr10

81107499

+REEP3chr10

65354538

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394579ENST00000298249PPIFchr10

81107499

+REEP3chr10

65354538

+
In-frameENST00000394579ENST00000373758PPIFchr10

81107499

+REEP3chr10

65354538

+
In-frameENST00000225174ENST00000298249PPIFchr10

81107499

+REEP3chr10

65354538

+
In-frameENST00000225174ENST00000373758PPIFchr10

81107499

+REEP3chr10

65354538

+
3UTR-3CDSENST00000492149ENST00000298249PPIFchr10

81107499

+REEP3chr10

65354538

+
3UTR-3CDSENST00000492149ENST00000373758PPIFchr10

81107499

+REEP3chr10

65354538

+

Top

FusionProtFeatures for PPIF_REEP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPIF

P30405

REEP3

Q6NUK4

PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). Involved in regulationof the mitochondrial permeability transition pore (mPTP). It isproposed that its association with the mPTP is masking a bindingsite for inhibiting inorganic phosphate (Pi) and promotes the openprobability of the mPTP leading to apoptosis or necrosis; therequirement of the PPIase activity for this function is debated.In cooperation with mitochondrial TP53 is involved in activatingoxidative stress-induced necrosis. Involved in modulation ofmitochondrial membrane F(1)F(0) ATP synthase activity andregulation of mitochondrial matrix adenine nucleotide levels. Hasanti-apoptotic activity independently of mPTP and in cooperationwith BCL2 inhibits cytochrome c-dependent apoptosis.{ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357,ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. Microtubule-binding protein required to ensure propercell division and nuclear envelope reassembly by sequestering theendoplasmic reticulum away from chromosomes during mitosis.Probably acts by clearing the endoplasmic reticulum membrane frommetaphase chromosomes. {ECO:0000269|PubMed:23911198}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneREEP3chr10:81107499chr10:65354538ENST00000373758+1835_5535256TransmembraneHelical
TgeneREEP3chr10:81107499chr10:65354538ENST00000373758+1859_7935256TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPIFchr10:81107499chr10:65354538ENST00000225174+1649_20565208DomainPPIase cyclophilin-type
TgeneREEP3chr10:81107499chr10:65354538ENST00000373758+181_2135256TransmembraneHelical


Top

FusionGeneSequence for PPIF_REEP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PPIF_ENST00000394579_chr10_81107499_+_REEP3_ENST00000298249_chr10_65354538_+_286aa
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLEVRWMMYWIVFALYTVIETVADQTVA
WFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRS
FSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRY

>In-frame_PPIF_ENST00000394579_chr10_81107499_+_REEP3_ENST00000373758_chr10_65354538_+_286aa
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLEVRWMMYWIVFALYTVIETVADQTVA
WFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRS
FSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRY

>In-frame_PPIF_ENST00000225174_chr10_81107499_+_REEP3_ENST00000298249_chr10_65354538_+_286aa
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLEVRWMMYWIVFALYTVIETVADQTVA
WFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRS
FSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRY

>In-frame_PPIF_ENST00000225174_chr10_81107499_+_REEP3_ENST00000373758_chr10_65354538_+_286aa
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLEVRWMMYWIVFALYTVIETVADQTVA
WFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRS
FSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PPIF_ENST00000394579_chr10_81107499_+_REEP3_ENST00000298249_chr10_65354538_+_858nt
ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGC
AGCAAGGGCTCCGGCGACCCGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC
CGCGTGGTGCTGGAGGTTCGATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCT
TGGTTTCCCCTGTACTATGAGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAA
TTCCTTCATCCACTTCTTTCTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAAC
TTTGGACGGCAAGGTTTAAACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGC
TTCAGTATGCATGATTTAACAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGT
AAACCAGCCCCCAGTGAATCAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCA
GATAATGAGATGTTAACACACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTAC

>In-frame_PPIF_ENST00000394579_chr10_81107499_+_REEP3_ENST00000373758_chr10_65354538_+_858nt
ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGC
AGCAAGGGCTCCGGCGACCCGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC
CGCGTGGTGCTGGAGGTTCGATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCT
TGGTTTCCCCTGTACTATGAGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAA
TTCCTTCATCCACTTCTTTCTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAAC
TTTGGACGGCAAGGTTTAAACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGC
TTCAGTATGCATGATTTAACAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGT
AAACCAGCCCCCAGTGAATCAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCA
GATAATGAGATGTTAACACACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTAC

>In-frame_PPIF_ENST00000225174_chr10_81107499_+_REEP3_ENST00000298249_chr10_65354538_+_858nt
ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGC
AGCAAGGGCTCCGGCGACCCGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC
CGCGTGGTGCTGGAGGTTCGATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCT
TGGTTTCCCCTGTACTATGAGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAA
TTCCTTCATCCACTTCTTTCTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAAC
TTTGGACGGCAAGGTTTAAACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGC
TTCAGTATGCATGATTTAACAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGT
AAACCAGCCCCCAGTGAATCAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCA
GATAATGAGATGTTAACACACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTAC

>In-frame_PPIF_ENST00000225174_chr10_81107499_+_REEP3_ENST00000373758_chr10_65354538_+_858nt
ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGC
AGCAAGGGCTCCGGCGACCCGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC
CGCGTGGTGCTGGAGGTTCGATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCT
TGGTTTCCCCTGTACTATGAGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAA
TTCCTTCATCCACTTCTTTCTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAAC
TTTGGACGGCAAGGTTTAAACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGC
TTCAGTATGCATGATTTAACAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGT
AAACCAGCCCCCAGTGAATCAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCA
GATAATGAGATGTTAACACACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PPIF_ENST00000394579_chr10_81107499_+_REEP3_ENST00000298249_chr10_65354538_+_5188nt
TCGGCCTTCTGGGCGCGCGCGACGTCAGTTTGAGTTCTGTGTTCTCCCCGCCCGTGTCCCGCCCGACCCGCGCCCGCGATGCTGGCGCTG
CGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCC
GGCGACCCGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGCCGCGTGGTGCTG
GAGGTTCGATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCTTGGTTTCCCCTG
TACTATGAGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAATTCCTTCATCCA
CTTCTTTCTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAACTTTGGACGGCAA
GGTTTAAACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGCTTCAGTATGCAT
GATTTAACAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGTAAACCAGCCCCC
AGTGAATCAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCAGATAATGAGATG
TTAACACACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTACGGGTCACTAAAA
TACAAAGTGAAGAAACGACCACAAGTGTATTTTTAGTCATCTACACGTCAAATATCCCAAGACAGATTATGCTAAATACATCGACTTCAT
CTTCTAACATGATATATTCAGGATTTACACATTAAAATGATTATTTAAATTGTGGCAGTGATGGGGTTTACTTTCATGAATTTAAATTGT
TTTTATTTCTGTAACAATTGCTTCCAAATATTGACTACTAAAGGCAGTTCTGCAAGATGTACTAAATATGTATATTAGAAATTATAGAAA
ATCATGTTGTCCGTTTTCAAATTCATCAACAGCCTAGAGTGCCTGAGATATAAGATGAAACACAAATCCACAGTATACTTGAAAGGAGCC
TTTTTACGGTTCAGGATAAATCAGCCTTTGTGATGTACTGTGTTTACCTCCTTTTGTGTTGTATCTGGTAATTAAATAGGCCTCAGATTC
AGCAGTGACATAACAAGGACATAATGTAAGATAATAAAGTAGGTTTTATATATTCTTTAAATTTTTACTTATATAATACTTTCTAGTTTT
TCCACCATCAGCTGAAAGTTTTTGAAACAAATATTTGAAAACCAGGTATCCACACATAGCACTTTTATTCCTGACTAGTTTTGCACACTT
GAAAATTGTTTACTTATTTTACAACTGTTTTACTGATGCTATCTTTATTGTTTTTGCCGTATTCTGACATGTCAAATCTATGCCTTGAAT
TATATCATCTCTTTTCCTGTGGGTTTCATTTGTTAAATTCATTGGATTTTAATAATATAAAAGTATAGCTAATTGTTCAGTTTTAACTAT
TTTTAATTATCTTCTTAACAAATAAGAAGTTGCTTTAAACATTAACCAATTTTCTATATTTAGCTATACAGAGTAATTGAACTTAACATG
TTTTTGTCAACACCAATTACATTTTCAGCTTTTAAAAATGGTAGCTTTTGTGAAATAGAATCAGTGACCAGTATAGCACTTAGATCCCTT
CTAACTCATATAATTTTTCTCAGCCAATCCATTCACAAGCTTGGCATTGACATGTGCTGCTAGTTTATAAACTGGCATTGACGAAAATCA
TTTGAATCTCTTCTGGCTGAGATAATTTGCCAATGCAAAATACAGTTGTCATTAATCCTGCACATTAGAAATTATTAGAAACATATTACT
TTTTAACTTTAAATCTCAAAGAGATTTTGAGTTATTGAATTCTTAAGGCTTTCTTAGCTTGAACTGATAACTATGCATTATGAACCCTAA
GTCAATATATTTTTGGTGGTTTTAGTGATCAGTAATCAAATTTGTACTTATTATGCTTGTTCAGGTAATTTACTTGACTGTTCTATTTGT
TTGTCCAAAAGATAAAATGATGAGAGAGATTCGAGAGGTCTTTGATCTGTCTCCCTTTTAAGAAATGAAGCCAGCTGGTAATGTATATTC
AGGACTTCCTCAGAGTATTGGCCAAGAACATAATGTTTACACAGGAGTACCTTGGTATAATGCATACATTGTCTCATGATACTAGTCATA
AAATATTTTATGGATTATTTCACATTCTTCATATATAACAAGTAAAATTAATTCAGTTTTCTTCTCCCAACGTTTAATTCTGAATAACTC
TATCTACTTTACCCTAATTTTTAGCCTCTTAATTTCTGGAAGGACTCTAATTTCTATTCCAAATTTCTATGAATTCTAATTGTAAATTAT
CGGAACAGAGTTTTATTTATATGACCTGGTACTAGACTTCTTAATATAACTGTTACACTGTCCTTGTCTTTCCTACTCAAAGACAGTATC
ATCTGAAGTTGCCTAATAAGGTCATGTGAGTCAAGAACTTTATCTGTGGGAGCTGATTTGCACCATTTTACCTTTTTTTTTTTTTTTTTT
TTGAGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTACAACCTCTGCCTCCCGGGTTCGAGCGATT
CTCCTGCCTCGGCCTCCCGAGTAACTGGGTCTACAGGCCCGTGCTACCACGCCCAGCTAATTTTTGTCTTTTTAGTAGAGACAGGGTTTA
ACCATGTTGCCCAGGATGGTCTCCATCTCTTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAACTTCTGGGATTACAGGCGTGAGCCAC
CGCACCCAGCCACCATTTTATCTCTCTAAAGTCTGGTCCCAGTATTAAACCTATTCTTTAGTAAACTCATATTACTGTTCTAAATTGAAG
AAATTATTTATTACTCTGTACTTCTAGACTCAAAATTCTTTATCAAAGATAGTCTCAAAGAGGTAGTACAAGTCCTGTTTAACTGCACTT
TTTCACATTCACAGTGCTTCCTCTGATATCTTTCCTTACATCATTATACACTGTTGATATCATTTTACTCTTCTTTCTCTTCTACATTTC
TTAAATTTTGGTTCTTTTCCTGTACATGTGTTTTAGCGGGGCCCTTTTCTTTGAACTTTGTCTAATTAGCCTGTACATTTTTGTTTCTTT
TAAGGTAGAACAGATCTTTTTTTGTTTCTCCTTTTAAGTCTACTGGTTTTAAAAGAGGTAAATGTATCCATAGACCACAGTGCCTTGCTT
TTTCCTCTGCCAGCACATGGAGCACGGGATTAGATGCACAAACCTATTTAGGGAACTATTTTGGTAGATGTTTGAGTTTATACAGAAATT
GCAGCTGGTATTTTATTTTGCTGTACATTTACTCAACTTGTCCATTAGTATTTAACTATTTCCAGAGTTTGTTTAGGAGTAAGAATTGAC
CCATTCGTTAGTTTACCATATTTTTTCCTGGTATAAAAAGGAGCCAGAAATAAGCCTTATTGCTAAATAATTAATTATGTAAGCCCACCT
AGGTCCTGCATAAGATCCCCCTCACATACTTCACAATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTG
GCTAAAAAATTATACTGCCAAAATTACTGATTATAAATACTTGACTACACTGATTGATGGGACAAAATGATTAAAGTATTTTCAGGGATC
TTATTCCATATGTCACCACCAAAGATTTCTACAGTGTTATAAAGTATATAAATATTCCAAATTTCTGTGGTTAAATATTTTTTTCTTTTT
TTTCCTTTTTTAGAATAACACAGTCTGTGCTTTCCAAAAATGCTTGAACTTTTATGTTGTTAAGAAATATATAATGATATCTTACATTAA
GCATGAGTCTAATTTGTATTAATTGGGATGGACTAAATTTTCATTTGATTATCAGGAAAATTAAGGAGTTATATATTTAAAAGCAATTTT
CTGTGTTTTCTTCTTTGTAAGTTGACTCATTTGTGAAGCAATTAGGCAAATTTTGAGAAGATCATTGTTATTGTGGTTTGCAGTATATAT
TTCTTAGTAAATATCACTTAAGATTAAATTTTTCAGAAAGAAAATTATAGCTTTTTTCCCAAAATATTTTTAAGATTTAATCTTTTTGTA
GTATGCTACAGATTTAATTATATTAACTCTTTTTTAAGACATTGACCATGACTTAACATTTTGCCTTCTAACACCTTTTAAATCTATGTA
CTTTAATAGTTAAGAGAAAATAAGTTTGCAGATTTTTAATAATCTGTTTGTAAAAGGCTATCTCTAAGCCTAGTATGTGGGTAATTTTAC
AGGTGTGTTTTTTGATAACTTTAATATAAAATAAACTCATTTTATTTGTGGCAATTCGCGTTTCTTTTTTTATGCCAGAGTACATATGTT
GGATTCCATGAATTGGTATTACTTATTATTATGTGTTGATTAAATATATGCACACACTTAGGATTACAGATCACAGAGCAAATTATGAAA
ATCATAAACATTCTGGTATGGTCATCCATAGGATTATGAAAAAGAAATACTGAATTGTTAAATTTGGATGTTAGAAAGGAAAGATAGGAA
AAACAATGAGTACAGAAATCCTCACCATCAATTTGGATGGGTTAGCTGTCTCAGGCATAAAATGTAACACAAAATTCAGATTTATGTATC
CTGGAAATGTTCTGGGGTTCCATCTGTTTTAAAGTTAGACGTCTGTCTGCCTCACATTTAAGCTTTAGAGAGAAATCCTATGTTTTAAGA
AGTTTCTTTGTGTTACTTCATTATGACACATAATGCGTGTTAAGGTCTTTCTAGATAGCATTTTAAATGGAATTATTTTCATTTTCATTA

>In-frame_PPIF_ENST00000394579_chr10_81107499_+_REEP3_ENST00000373758_chr10_65354538_+_5190nt
TCGGCCTTCTGGGCGCGCGCGACGTCAGTTTGAGTTCTGTGTTCTCCCCGCCCGTGTCCCGCCCGACCCGCGCCCGCGATGCTGGCGCTG
CGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCC
GGCGACCCGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGCCGCGTGGTGCTG
GAGGTTCGATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCTTGGTTTCCCCTG
TACTATGAGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAATTCCTTCATCCA
CTTCTTTCTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAACTTTGGACGGCAA
GGTTTAAACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGCTTCAGTATGCAT
GATTTAACAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGTAAACCAGCCCCC
AGTGAATCAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCAGATAATGAGATG
TTAACACACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTACGGGTCACTAAAA
TACAAAGTGAAGAAACGACCACAAGTGTATTTTTAGTCATCTACACGTCAAATATCCCAAGACAGATTATGCTAAATACATCGACTTCAT
CTTCTAACATGATATATTCAGGATTTACACATTAAAATGATTATTTAAATTGTGGCAGTGATGGGGTTTACTTTCATGAATTTAAATTGT
TTTTATTTCTGTAACAATTGCTTCCAAATATTGACTACTAAAGGCAGTTCTGCAAGATGTACTAAATATGTATATTAGAAATTATAGAAA
ATCATGTTGTCCGTTTTCAAATTCATCAACAGCCTAGAGTGCCTGAGATATAAGATGAAACACAAATCCACAGTATACTTGAAAGGAGCC
TTTTTACGGTTCAGGATAAATCAGCCTTTGTGATGTACTGTGTTTACCTCCTTTTGTGTTGTATCTGGTAATTAAATAGGCCTCAGATTC
AGCAGTGACATAACAAGGACATAATGTAAGATAATAAAGTAGGTTTTATATATTCTTTAAATTTTTACTTATATAATACTTTCTAGTTTT
TCCACCATCAGCTGAAAGTTTTTGAAACAAATATTTGAAAACCAGGTATCCACACATAGCACTTTTATTCCTGACTAGTTTTGCACACTT
GAAAATTGTTTACTTATTTTACAACTGTTTTACTGATGCTATCTTTATTGTTTTTGCCGTATTCTGACATGTCAAATCTATGCCTTGAAT
TATATCATCTCTTTTCCTGTGGGTTTCATTTGTTAAATTCATTGGATTTTAATAATATAAAAGTATAGCTAATTGTTCAGTTTTAACTAT
TTTTAATTATCTTCTTAACAAATAAGAAGTTGCTTTAAACATTAACCAATTTTCTATATTTAGCTATACAGAGTAATTGAACTTAACATG
TTTTTGTCAACACCAATTACATTTTCAGCTTTTAAAAATGGTAGCTTTTGTGAAATAGAATCAGTGACCAGTATAGCACTTAGATCCCTT
CTAACTCATATAATTTTTCTCAGCCAATCCATTCACAAGCTTGGCATTGACATGTGCTGCTAGTTTATAAACTGGCATTGACGAAAATCA
TTTGAATCTCTTCTGGCTGAGATAATTTGCCAATGCAAAATACAGTTGTCATTAATCCTGCACATTAGAAATTATTAGAAACATATTACT
TTTTAACTTTAAATCTCAAAGAGATTTTGAGTTATTGAATTCTTAAGGCTTTCTTAGCTTGAACTGATAACTATGCATTATGAACCCTAA
GTCAATATATTTTTGGTGGTTTTAGTGATCAGTAATCAAATTTGTACTTATTATGCTTGTTCAGGTAATTTACTTGACTGTTCTATTTGT
TTGTCCAAAAGATAAAATGATGAGAGAGATTCGAGAGGTCTTTGATCTGTCTCCCTTTTAAGAAATGAAGCCAGCTGGTAATGTATATTC
AGGACTTCCTCAGAGTATTGGCCAAGAACATAATGTTTACACAGGAGTACCTTGGTATAATGCATACATTGTCTCATGATACTAGTCATA
AAATATTTTATGGATTATTTCACATTCTTCATATATAACAAGTAAAATTAATTCAGTTTTCTTCTCCCAACGTTTAATTCTGAATAACTC
TATCTACTTTACCCTAATTTTTAGCCTCTTAATTTCTGGAAGGACTCTAATTTCTATTCCAAATTTCTATGAATTCTAATTGTAAATTAT
CGGAACAGAGTTTTATTTATATGACCTGGTACTAGACTTCTTAATATAACTGTTACACTGTCCTTGTCTTTCCTACTCAAAGACAGTATC
ATCTGAAGTTGCCTAATAAGGTCATGTGAGTCAAGAACTTTATCTGTGGGAGCTGATTTGCACCATTTTACCTTTTTTTTTTTTTTTTTT
TTGAGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTACAACCTCTGCCTCCCGGGTTCGAGCGATT
CTCCTGCCTCGGCCTCCCGAGTAACTGGGTCTACAGGCCCGTGCTACCACGCCCAGCTAATTTTTGTCTTTTTAGTAGAGACAGGGTTTA
ACCATGTTGCCCAGGATGGTCTCCATCTCTTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAACTTCTGGGATTACAGGCGTGAGCCAC
CGCACCCAGCCACCATTTTATCTCTCTAAAGTCTGGTCCCAGTATTAAACCTATTCTTTAGTAAACTCATATTACTGTTCTAAATTGAAG
AAATTATTTATTACTCTGTACTTCTAGACTCAAAATTCTTTATCAAAGATAGTCTCAAAGAGGTAGTACAAGTCCTGTTTAACTGCACTT
TTTCACATTCACAGTGCTTCCTCTGATATCTTTCCTTACATCATTATACACTGTTGATATCATTTTACTCTTCTTTCTCTTCTACATTTC
TTAAATTTTGGTTCTTTTCCTGTACATGTGTTTTAGCGGGGCCCTTTTCTTTGAACTTTGTCTAATTAGCCTGTACATTTTTGTTTCTTT
TAAGGTAGAACAGATCTTTTTTTGTTTCTCCTTTTAAGTCTACTGGTTTTAAAAGAGGTAAATGTATCCATAGACCACAGTGCCTTGCTT
TTTCCTCTGCCAGCACATGGAGCACGGGATTAGATGCACAAACCTATTTAGGGAACTATTTTGGTAGATGTTTGAGTTTATACAGAAATT
GCAGCTGGTATTTTATTTTGCTGTACATTTACTCAACTTGTCCATTAGTATTTAACTATTTCCAGAGTTTGTTTAGGAGTAAGAATTGAC
CCATTCGTTAGTTTACCATATTTTTTCCTGGTATAAAAAGGAGCCAGAAATAAGCCTTATTGCTAAATAATTAATTATGTAAGCCCACCT
AGGTCCTGCATAAGATCCCCCTCACATACTTCACAATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTG
GCTAAAAAATTATACTGCCAAAATTACTGATTATAAATACTTGACTACACTGATTGATGGGACAAAATGATTAAAGTATTTTCAGGGATC
TTATTCCATATGTCACCACCAAAGATTTCTACAGTGTTATAAAGTATATAAATATTCCAAATTTCTGTGGTTAAATATTTTTTTCTTTTT
TTTCCTTTTTTAGAATAACACAGTCTGTGCTTTCCAAAAATGCTTGAACTTTTATGTTGTTAAGAAATATATAATGATATCTTACATTAA
GCATGAGTCTAATTTGTATTAATTGGGATGGACTAAATTTTCATTTGATTATCAGGAAAATTAAGGAGTTATATATTTAAAAGCAATTTT
CTGTGTTTTCTTCTTTGTAAGTTGACTCATTTGTGAAGCAATTAGGCAAATTTTGAGAAGATCATTGTTATTGTGGTTTGCAGTATATAT
TTCTTAGTAAATATCACTTAAGATTAAATTTTTCAGAAAGAAAATTATAGCTTTTTTCCCAAAATATTTTTAAGATTTAATCTTTTTGTA
GTATGCTACAGATTTAATTATATTAACTCTTTTTTAAGACATTGACCATGACTTAACATTTTGCCTTCTAACACCTTTTAAATCTATGTA
CTTTAATAGTTAAGAGAAAATAAGTTTGCAGATTTTTAATAATCTGTTTGTAAAAGGCTATCTCTAAGCCTAGTATGTGGGTAATTTTAC
AGGTGTGTTTTTTGATAACTTTAATATAAAATAAACTCATTTTATTTGTGGCAATTCGCGTTTCTTTTTTTATGCCAGAGTACATATGTT
GGATTCCATGAATTGGTATTACTTATTATTATGTGTTGATTAAATATATGCACACACTTAGGATTACAGATCACAGAGCAAATTATGAAA
ATCATAAACATTCTGGTATGGTCATCCATAGGATTATGAAAAAGAAATACTGAATTGTTAAATTTGGATGTTAGAAAGGAAAGATAGGAA
AAACAATGAGTACAGAAATCCTCACCATCAATTTGGATGGGTTAGCTGTCTCAGGCATAAAATGTAACACAAAATTCAGATTTATGTATC
CTGGAAATGTTCTGGGGTTCCATCTGTTTTAAAGTTAGACGTCTGTCTGCCTCACATTTAAGCTTTAGAGAGAAATCCTATGTTTTAAGA
AGTTTCTTTGTGTTACTTCATTATGACACATAATGCGTGTTAAGGTCTTTCTAGATAGCATTTTAAATGGAATTATTTTCATTTTCATTA

>In-frame_PPIF_ENST00000225174_chr10_81107499_+_REEP3_ENST00000298249_chr10_65354538_+_5181nt
TCTGGGCGCGCGCGACGTCAGTTTGAGTTCTGTGTTCTCCCCGCCCGTGTCCCGCCCGACCCGCGCCCGCGATGCTGGCGCTGCGCTGCG
GCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCCGGCGACC
CGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGCCGCGTGGTGCTGGAGGTTC
GATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCTTGGTTTCCCCTGTACTATG
AGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAATTCCTTCATCCACTTCTTT
CTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAACTTTGGACGGCAAGGTTTAA
ACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGCTTCAGTATGCATGATTTAA
CAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGTAAACCAGCCCCCAGTGAAT
CAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCAGATAATGAGATGTTAACAC
ACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTACGGGTCACTAAAATACAAAG
TGAAGAAACGACCACAAGTGTATTTTTAGTCATCTACACGTCAAATATCCCAAGACAGATTATGCTAAATACATCGACTTCATCTTCTAA
CATGATATATTCAGGATTTACACATTAAAATGATTATTTAAATTGTGGCAGTGATGGGGTTTACTTTCATGAATTTAAATTGTTTTTATT
TCTGTAACAATTGCTTCCAAATATTGACTACTAAAGGCAGTTCTGCAAGATGTACTAAATATGTATATTAGAAATTATAGAAAATCATGT
TGTCCGTTTTCAAATTCATCAACAGCCTAGAGTGCCTGAGATATAAGATGAAACACAAATCCACAGTATACTTGAAAGGAGCCTTTTTAC
GGTTCAGGATAAATCAGCCTTTGTGATGTACTGTGTTTACCTCCTTTTGTGTTGTATCTGGTAATTAAATAGGCCTCAGATTCAGCAGTG
ACATAACAAGGACATAATGTAAGATAATAAAGTAGGTTTTATATATTCTTTAAATTTTTACTTATATAATACTTTCTAGTTTTTCCACCA
TCAGCTGAAAGTTTTTGAAACAAATATTTGAAAACCAGGTATCCACACATAGCACTTTTATTCCTGACTAGTTTTGCACACTTGAAAATT
GTTTACTTATTTTACAACTGTTTTACTGATGCTATCTTTATTGTTTTTGCCGTATTCTGACATGTCAAATCTATGCCTTGAATTATATCA
TCTCTTTTCCTGTGGGTTTCATTTGTTAAATTCATTGGATTTTAATAATATAAAAGTATAGCTAATTGTTCAGTTTTAACTATTTTTAAT
TATCTTCTTAACAAATAAGAAGTTGCTTTAAACATTAACCAATTTTCTATATTTAGCTATACAGAGTAATTGAACTTAACATGTTTTTGT
CAACACCAATTACATTTTCAGCTTTTAAAAATGGTAGCTTTTGTGAAATAGAATCAGTGACCAGTATAGCACTTAGATCCCTTCTAACTC
ATATAATTTTTCTCAGCCAATCCATTCACAAGCTTGGCATTGACATGTGCTGCTAGTTTATAAACTGGCATTGACGAAAATCATTTGAAT
CTCTTCTGGCTGAGATAATTTGCCAATGCAAAATACAGTTGTCATTAATCCTGCACATTAGAAATTATTAGAAACATATTACTTTTTAAC
TTTAAATCTCAAAGAGATTTTGAGTTATTGAATTCTTAAGGCTTTCTTAGCTTGAACTGATAACTATGCATTATGAACCCTAAGTCAATA
TATTTTTGGTGGTTTTAGTGATCAGTAATCAAATTTGTACTTATTATGCTTGTTCAGGTAATTTACTTGACTGTTCTATTTGTTTGTCCA
AAAGATAAAATGATGAGAGAGATTCGAGAGGTCTTTGATCTGTCTCCCTTTTAAGAAATGAAGCCAGCTGGTAATGTATATTCAGGACTT
CCTCAGAGTATTGGCCAAGAACATAATGTTTACACAGGAGTACCTTGGTATAATGCATACATTGTCTCATGATACTAGTCATAAAATATT
TTATGGATTATTTCACATTCTTCATATATAACAAGTAAAATTAATTCAGTTTTCTTCTCCCAACGTTTAATTCTGAATAACTCTATCTAC
TTTACCCTAATTTTTAGCCTCTTAATTTCTGGAAGGACTCTAATTTCTATTCCAAATTTCTATGAATTCTAATTGTAAATTATCGGAACA
GAGTTTTATTTATATGACCTGGTACTAGACTTCTTAATATAACTGTTACACTGTCCTTGTCTTTCCTACTCAAAGACAGTATCATCTGAA
GTTGCCTAATAAGGTCATGTGAGTCAAGAACTTTATCTGTGGGAGCTGATTTGCACCATTTTACCTTTTTTTTTTTTTTTTTTTTGAGAC
GGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTACAACCTCTGCCTCCCGGGTTCGAGCGATTCTCCTGC
CTCGGCCTCCCGAGTAACTGGGTCTACAGGCCCGTGCTACCACGCCCAGCTAATTTTTGTCTTTTTAGTAGAGACAGGGTTTAACCATGT
TGCCCAGGATGGTCTCCATCTCTTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAACTTCTGGGATTACAGGCGTGAGCCACCGCACCC
AGCCACCATTTTATCTCTCTAAAGTCTGGTCCCAGTATTAAACCTATTCTTTAGTAAACTCATATTACTGTTCTAAATTGAAGAAATTAT
TTATTACTCTGTACTTCTAGACTCAAAATTCTTTATCAAAGATAGTCTCAAAGAGGTAGTACAAGTCCTGTTTAACTGCACTTTTTCACA
TTCACAGTGCTTCCTCTGATATCTTTCCTTACATCATTATACACTGTTGATATCATTTTACTCTTCTTTCTCTTCTACATTTCTTAAATT
TTGGTTCTTTTCCTGTACATGTGTTTTAGCGGGGCCCTTTTCTTTGAACTTTGTCTAATTAGCCTGTACATTTTTGTTTCTTTTAAGGTA
GAACAGATCTTTTTTTGTTTCTCCTTTTAAGTCTACTGGTTTTAAAAGAGGTAAATGTATCCATAGACCACAGTGCCTTGCTTTTTCCTC
TGCCAGCACATGGAGCACGGGATTAGATGCACAAACCTATTTAGGGAACTATTTTGGTAGATGTTTGAGTTTATACAGAAATTGCAGCTG
GTATTTTATTTTGCTGTACATTTACTCAACTTGTCCATTAGTATTTAACTATTTCCAGAGTTTGTTTAGGAGTAAGAATTGACCCATTCG
TTAGTTTACCATATTTTTTCCTGGTATAAAAAGGAGCCAGAAATAAGCCTTATTGCTAAATAATTAATTATGTAAGCCCACCTAGGTCCT
GCATAAGATCCCCCTCACATACTTCACAATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGGCTAAAA
AATTATACTGCCAAAATTACTGATTATAAATACTTGACTACACTGATTGATGGGACAAAATGATTAAAGTATTTTCAGGGATCTTATTCC
ATATGTCACCACCAAAGATTTCTACAGTGTTATAAAGTATATAAATATTCCAAATTTCTGTGGTTAAATATTTTTTTCTTTTTTTTCCTT
TTTTAGAATAACACAGTCTGTGCTTTCCAAAAATGCTTGAACTTTTATGTTGTTAAGAAATATATAATGATATCTTACATTAAGCATGAG
TCTAATTTGTATTAATTGGGATGGACTAAATTTTCATTTGATTATCAGGAAAATTAAGGAGTTATATATTTAAAAGCAATTTTCTGTGTT
TTCTTCTTTGTAAGTTGACTCATTTGTGAAGCAATTAGGCAAATTTTGAGAAGATCATTGTTATTGTGGTTTGCAGTATATATTTCTTAG
TAAATATCACTTAAGATTAAATTTTTCAGAAAGAAAATTATAGCTTTTTTCCCAAAATATTTTTAAGATTTAATCTTTTTGTAGTATGCT
ACAGATTTAATTATATTAACTCTTTTTTAAGACATTGACCATGACTTAACATTTTGCCTTCTAACACCTTTTAAATCTATGTACTTTAAT
AGTTAAGAGAAAATAAGTTTGCAGATTTTTAATAATCTGTTTGTAAAAGGCTATCTCTAAGCCTAGTATGTGGGTAATTTTACAGGTGTG
TTTTTTGATAACTTTAATATAAAATAAACTCATTTTATTTGTGGCAATTCGCGTTTCTTTTTTTATGCCAGAGTACATATGTTGGATTCC
ATGAATTGGTATTACTTATTATTATGTGTTGATTAAATATATGCACACACTTAGGATTACAGATCACAGAGCAAATTATGAAAATCATAA
ACATTCTGGTATGGTCATCCATAGGATTATGAAAAAGAAATACTGAATTGTTAAATTTGGATGTTAGAAAGGAAAGATAGGAAAAACAAT
GAGTACAGAAATCCTCACCATCAATTTGGATGGGTTAGCTGTCTCAGGCATAAAATGTAACACAAAATTCAGATTTATGTATCCTGGAAA
TGTTCTGGGGTTCCATCTGTTTTAAAGTTAGACGTCTGTCTGCCTCACATTTAAGCTTTAGAGAGAAATCCTATGTTTTAAGAAGTTTCT
TTGTGTTACTTCATTATGACACATAATGCGTGTTAAGGTCTTTCTAGATAGCATTTTAAATGGAATTATTTTCATTTTCATTATGAGGTA

>In-frame_PPIF_ENST00000225174_chr10_81107499_+_REEP3_ENST00000373758_chr10_65354538_+_5183nt
TCTGGGCGCGCGCGACGTCAGTTTGAGTTCTGTGTTCTCCCCGCCCGTGTCCCGCCCGACCCGCGCCCGCGATGCTGGCGCTGCGCTGCG
GCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTGCCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCCGGCGACC
CGTCCTCTTCCTCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGCCGCGTGGTGCTGGAGGTTC
GATGGATGATGTACTGGATTGTTTTTGCTCTCTATACTGTGATTGAAACAGTAGCCGATCAAACAGTTGCTTGGTTTCCCCTGTACTATG
AGCTGAAGATTGCTTTTGTCATATGGCTGCTTTCTCCCTATACCAAAGGAGCAAGTTTAATATATAGAAAATTCCTTCATCCACTTCTTT
CTTCAAAGGAAAGGGAGATTGATGATTATATTGTACAAGCAAAGGAACGAGGCTATGAAACCATGGTAAACTTTGGACGGCAAGGTTTAA
ACCTTGCAGCTACTGCTGCTGTTACTGCAGCAGTAAAGAGCCAAGGAGCAATAACTGAACGTTTAAGAAGCTTCAGTATGCATGATTTAA
CAACTATCCAAGGTGATGAGCCTGTGGGACAAAGACCATACCAACCTCTACCAGAAGCAAAAAAGAAAAGTAAACCAGCCCCCAGTGAAT
CAGCAGGTTATGGAATTCCACTGAAAGACGGAGATGAGAAAACAGATGAAGAAGCAGAGGGGCCATATTCAGATAATGAGATGTTAACAC
ACAAAGGGCTTCGAAGATCGCAAAGCATGAAATCTGTGAAAACCACCAAAGGCCGCAAAGAGGTGCGGTACGGGTCACTAAAATACAAAG
TGAAGAAACGACCACAAGTGTATTTTTAGTCATCTACACGTCAAATATCCCAAGACAGATTATGCTAAATACATCGACTTCATCTTCTAA
CATGATATATTCAGGATTTACACATTAAAATGATTATTTAAATTGTGGCAGTGATGGGGTTTACTTTCATGAATTTAAATTGTTTTTATT
TCTGTAACAATTGCTTCCAAATATTGACTACTAAAGGCAGTTCTGCAAGATGTACTAAATATGTATATTAGAAATTATAGAAAATCATGT
TGTCCGTTTTCAAATTCATCAACAGCCTAGAGTGCCTGAGATATAAGATGAAACACAAATCCACAGTATACTTGAAAGGAGCCTTTTTAC
GGTTCAGGATAAATCAGCCTTTGTGATGTACTGTGTTTACCTCCTTTTGTGTTGTATCTGGTAATTAAATAGGCCTCAGATTCAGCAGTG
ACATAACAAGGACATAATGTAAGATAATAAAGTAGGTTTTATATATTCTTTAAATTTTTACTTATATAATACTTTCTAGTTTTTCCACCA
TCAGCTGAAAGTTTTTGAAACAAATATTTGAAAACCAGGTATCCACACATAGCACTTTTATTCCTGACTAGTTTTGCACACTTGAAAATT
GTTTACTTATTTTACAACTGTTTTACTGATGCTATCTTTATTGTTTTTGCCGTATTCTGACATGTCAAATCTATGCCTTGAATTATATCA
TCTCTTTTCCTGTGGGTTTCATTTGTTAAATTCATTGGATTTTAATAATATAAAAGTATAGCTAATTGTTCAGTTTTAACTATTTTTAAT
TATCTTCTTAACAAATAAGAAGTTGCTTTAAACATTAACCAATTTTCTATATTTAGCTATACAGAGTAATTGAACTTAACATGTTTTTGT
CAACACCAATTACATTTTCAGCTTTTAAAAATGGTAGCTTTTGTGAAATAGAATCAGTGACCAGTATAGCACTTAGATCCCTTCTAACTC
ATATAATTTTTCTCAGCCAATCCATTCACAAGCTTGGCATTGACATGTGCTGCTAGTTTATAAACTGGCATTGACGAAAATCATTTGAAT
CTCTTCTGGCTGAGATAATTTGCCAATGCAAAATACAGTTGTCATTAATCCTGCACATTAGAAATTATTAGAAACATATTACTTTTTAAC
TTTAAATCTCAAAGAGATTTTGAGTTATTGAATTCTTAAGGCTTTCTTAGCTTGAACTGATAACTATGCATTATGAACCCTAAGTCAATA
TATTTTTGGTGGTTTTAGTGATCAGTAATCAAATTTGTACTTATTATGCTTGTTCAGGTAATTTACTTGACTGTTCTATTTGTTTGTCCA
AAAGATAAAATGATGAGAGAGATTCGAGAGGTCTTTGATCTGTCTCCCTTTTAAGAAATGAAGCCAGCTGGTAATGTATATTCAGGACTT
CCTCAGAGTATTGGCCAAGAACATAATGTTTACACAGGAGTACCTTGGTATAATGCATACATTGTCTCATGATACTAGTCATAAAATATT
TTATGGATTATTTCACATTCTTCATATATAACAAGTAAAATTAATTCAGTTTTCTTCTCCCAACGTTTAATTCTGAATAACTCTATCTAC
TTTACCCTAATTTTTAGCCTCTTAATTTCTGGAAGGACTCTAATTTCTATTCCAAATTTCTATGAATTCTAATTGTAAATTATCGGAACA
GAGTTTTATTTATATGACCTGGTACTAGACTTCTTAATATAACTGTTACACTGTCCTTGTCTTTCCTACTCAAAGACAGTATCATCTGAA
GTTGCCTAATAAGGTCATGTGAGTCAAGAACTTTATCTGTGGGAGCTGATTTGCACCATTTTACCTTTTTTTTTTTTTTTTTTTTGAGAC
GGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTACAACCTCTGCCTCCCGGGTTCGAGCGATTCTCCTGC
CTCGGCCTCCCGAGTAACTGGGTCTACAGGCCCGTGCTACCACGCCCAGCTAATTTTTGTCTTTTTAGTAGAGACAGGGTTTAACCATGT
TGCCCAGGATGGTCTCCATCTCTTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAACTTCTGGGATTACAGGCGTGAGCCACCGCACCC
AGCCACCATTTTATCTCTCTAAAGTCTGGTCCCAGTATTAAACCTATTCTTTAGTAAACTCATATTACTGTTCTAAATTGAAGAAATTAT
TTATTACTCTGTACTTCTAGACTCAAAATTCTTTATCAAAGATAGTCTCAAAGAGGTAGTACAAGTCCTGTTTAACTGCACTTTTTCACA
TTCACAGTGCTTCCTCTGATATCTTTCCTTACATCATTATACACTGTTGATATCATTTTACTCTTCTTTCTCTTCTACATTTCTTAAATT
TTGGTTCTTTTCCTGTACATGTGTTTTAGCGGGGCCCTTTTCTTTGAACTTTGTCTAATTAGCCTGTACATTTTTGTTTCTTTTAAGGTA
GAACAGATCTTTTTTTGTTTCTCCTTTTAAGTCTACTGGTTTTAAAAGAGGTAAATGTATCCATAGACCACAGTGCCTTGCTTTTTCCTC
TGCCAGCACATGGAGCACGGGATTAGATGCACAAACCTATTTAGGGAACTATTTTGGTAGATGTTTGAGTTTATACAGAAATTGCAGCTG
GTATTTTATTTTGCTGTACATTTACTCAACTTGTCCATTAGTATTTAACTATTTCCAGAGTTTGTTTAGGAGTAAGAATTGACCCATTCG
TTAGTTTACCATATTTTTTCCTGGTATAAAAAGGAGCCAGAAATAAGCCTTATTGCTAAATAATTAATTATGTAAGCCCACCTAGGTCCT
GCATAAGATCCCCCTCACATACTTCACAATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGGCTAAAA
AATTATACTGCCAAAATTACTGATTATAAATACTTGACTACACTGATTGATGGGACAAAATGATTAAAGTATTTTCAGGGATCTTATTCC
ATATGTCACCACCAAAGATTTCTACAGTGTTATAAAGTATATAAATATTCCAAATTTCTGTGGTTAAATATTTTTTTCTTTTTTTTCCTT
TTTTAGAATAACACAGTCTGTGCTTTCCAAAAATGCTTGAACTTTTATGTTGTTAAGAAATATATAATGATATCTTACATTAAGCATGAG
TCTAATTTGTATTAATTGGGATGGACTAAATTTTCATTTGATTATCAGGAAAATTAAGGAGTTATATATTTAAAAGCAATTTTCTGTGTT
TTCTTCTTTGTAAGTTGACTCATTTGTGAAGCAATTAGGCAAATTTTGAGAAGATCATTGTTATTGTGGTTTGCAGTATATATTTCTTAG
TAAATATCACTTAAGATTAAATTTTTCAGAAAGAAAATTATAGCTTTTTTCCCAAAATATTTTTAAGATTTAATCTTTTTGTAGTATGCT
ACAGATTTAATTATATTAACTCTTTTTTAAGACATTGACCATGACTTAACATTTTGCCTTCTAACACCTTTTAAATCTATGTACTTTAAT
AGTTAAGAGAAAATAAGTTTGCAGATTTTTAATAATCTGTTTGTAAAAGGCTATCTCTAAGCCTAGTATGTGGGTAATTTTACAGGTGTG
TTTTTTGATAACTTTAATATAAAATAAACTCATTTTATTTGTGGCAATTCGCGTTTCTTTTTTTATGCCAGAGTACATATGTTGGATTCC
ATGAATTGGTATTACTTATTATTATGTGTTGATTAAATATATGCACACACTTAGGATTACAGATCACAGAGCAAATTATGAAAATCATAA
ACATTCTGGTATGGTCATCCATAGGATTATGAAAAAGAAATACTGAATTGTTAAATTTGGATGTTAGAAAGGAAAGATAGGAAAAACAAT
GAGTACAGAAATCCTCACCATCAATTTGGATGGGTTAGCTGTCTCAGGCATAAAATGTAACACAAAATTCAGATTTATGTATCCTGGAAA
TGTTCTGGGGTTCCATCTGTTTTAAAGTTAGACGTCTGTCTGCCTCACATTTAAGCTTTAGAGAGAAATCCTATGTTTTAAGAAGTTTCT
TTGTGTTACTTCATTATGACACATAATGCGTGTTAAGGTCTTTCTAGATAGCATTTTAAATGGAATTATTTTCATTTTCATTATGAGGTA


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FusionGenePPI for PPIF_REEP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPIFSLC25A4, VDAC3, ATP6V1E1, NABP2, SUGP1, TIMM44, STX7, MPLKIP, RBMS1, MRRF, MRPL14, ZC3H11A, RRBP1, MRPL53, SLIRP, TPX2, SRPRB, NDUFAF2, RANGAP1, UBE4B, PTPN11, ATF2, ABI2, BANP, CMTM5, GSTK1, AIFM3, FKBP1A, GPX4, HSPE1, NME1-NME2, SOD1, S100A10, TANGO2, TBL1XR1, SERPINB5REEP3YEATS4, MRPL50, SAMD1, BAG6, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CBY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPIF_REEP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePPIFP30405DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialsmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for PPIF_REEP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPIFC0021831Intestinal Diseases1CTD_human
HgenePPIFC0041582Ulcer1CTD_human
TgeneREEP3C0004352Autistic Disorder1CTD_human