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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28192

FusionGeneSummary for PPID_SFRP2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPID_SFRP2
Fusion gene ID: 28192
HgeneTgene
Gene symbol

PPID

SFRP2

Gene ID

5481

6423

Gene namepeptidylprolyl isomerase Dsecreted frizzled related protein 2
SynonymsCYP-40|CYPDFRP-2|SARP1|SDF-5
Cytomap

4q32.1

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase D40 kDa peptidyl-prolyl cis-trans isomerase DPPIase Dcyclophilin 40cyclophilin Dcyclophilin-related proteinrotamase Dtesticular tissue protein Li 147secreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170
Modification date2018052320180523
UniProtAcc

Q08752

Q96HF1

Ensembl transtripts involved in fusion geneENST00000307720, ENST00000274063, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: PPID [Title/Abstract] AND SFRP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPID

GO:0000413

protein peptidyl-prolyl isomerization

20676357

HgenePPID

GO:0061077

chaperone-mediated protein folding

11350175

HgenePPID

GO:0065003

protein-containing complex assembly

18708059

TgeneSFRP2

GO:0008284

positive regulation of cell proliferation

10980594

TgeneSFRP2

GO:0008285

negative regulation of cell proliferation

20208569

TgeneSFRP2

GO:0010719

negative regulation of epithelial to mesenchymal transition

19095296

TgeneSFRP2

GO:0030178

negative regulation of Wnt signaling pathway

20208569

TgeneSFRP2

GO:0030308

negative regulation of cell growth

20208569

TgeneSFRP2

GO:0045600

positive regulation of fat cell differentiation

12055200

TgeneSFRP2

GO:0045892

negative regulation of transcription, DNA-templated

19095296

TgeneSFRP2

GO:0050680

negative regulation of epithelial cell proliferation

19095296

TgeneSFRP2

GO:0090090

negative regulation of canonical Wnt signaling pathway

17471511


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0XN-01APPIDchr4

159640332

-SFRP2chr4

154702907

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000307720ENST00000274063PPIDchr4

159640332

-SFRP2chr4

154702907

-

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FusionProtFeatures for PPID_SFRP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPID

Q08752

SFRP2

Q96HF1

PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:11350175, PubMed:20676357).Proposed to act as a co-chaperone in HSP90 complexes such as inunligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thusestablishing distinct HSP90-co-chaperone-receptor complexes withthe potential to exert tissue-specific receptor activity control.May have a preference for estrogen receptor complexes and is notfound in glucocorticoid receptor complexes. May be involved incytoplasmic dynein-dependent movement of the receptor from thecytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling bypromoting the formation of the AHR:ARNT dimer; the function isindependent of HSP90 but requires the chaperone activity. Involvedin regulation of UV radiation-induced apoptosis. Promotes cellviability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.{ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779,ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}. (Microbial infection) May be involved in hepatitis Cvirus (HCV) replication and release. {ECO:0000269|PubMed:19932913,ECO:0000269|PubMed:21711559}. Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPID_SFRP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPID_SFRP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPIDHSPA8, HSP90AB1, ESR1, FES, HSF1, HAP1, KAT7, NPM1, CSNK2B, PLK1, LNX1, NR3C1, NR3C2, AR, HSP90AA1, APP, FN1, GNB2L1, RPS3, HSPA1A, XRCC6, ILF2, TUBA1A, TUBB, S100A2, S100A6, S100A1, FBXO25, HPRT1, GCLC, PSAT1, BCL2, AHSA1, CDC37, GPALPP1, PTGES3, TRIM27, PCBP4, UNK, PKM, DNAJB1, OAT, STIP1, PSMD12, SF1, NTRK1, FGB, UROD, AEN, TMA16, CCDC83, AKIRIN2, AMTN, FGF9, IQCB1SFRP2WNT4, ARMC8, MAEA, MKLN1, RMND5A, RANBP9, PPP1CC, SFRP5, PPP1CA, PPP1CB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPID_SFRP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPID_SFRP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPIDC0005586Bipolar Disorder1PSYGENET
TgeneSFRP2C0009404Colorectal Neoplasms2CTD_human
TgeneSFRP2C0007134Renal Cell Carcinoma1CTD_human
TgeneSFRP2C0021390Inflammatory Bowel Diseases1CTD_human
TgeneSFRP2C1458155Mammary Neoplasms1CTD_human