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Fusion gene ID: 28192 |
FusionGeneSummary for PPID_SFRP2 |
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Fusion gene information | Fusion gene name: PPID_SFRP2 | Fusion gene ID: 28192 | Hgene | Tgene | Gene symbol | PPID | SFRP2 | Gene ID | 5481 | 6423 |
Gene name | peptidylprolyl isomerase D | secreted frizzled related protein 2 | |
Synonyms | CYP-40|CYPD | FRP-2|SARP1|SDF-5 | |
Cytomap | 4q32.1 | 4q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | peptidyl-prolyl cis-trans isomerase D40 kDa peptidyl-prolyl cis-trans isomerase DPPIase Dcyclophilin 40cyclophilin Dcyclophilin-related proteinrotamase Dtesticular tissue protein Li 147 | secreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q08752 | Q96HF1 | |
Ensembl transtripts involved in fusion gene | ENST00000307720, | ENST00000274063, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PPID [Title/Abstract] AND SFRP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPID | GO:0000413 | protein peptidyl-prolyl isomerization | 20676357 |
Hgene | PPID | GO:0061077 | chaperone-mediated protein folding | 11350175 |
Hgene | PPID | GO:0065003 | protein-containing complex assembly | 18708059 |
Tgene | SFRP2 | GO:0008284 | positive regulation of cell proliferation | 10980594 |
Tgene | SFRP2 | GO:0008285 | negative regulation of cell proliferation | 20208569 |
Tgene | SFRP2 | GO:0010719 | negative regulation of epithelial to mesenchymal transition | 19095296 |
Tgene | SFRP2 | GO:0030178 | negative regulation of Wnt signaling pathway | 20208569 |
Tgene | SFRP2 | GO:0030308 | negative regulation of cell growth | 20208569 |
Tgene | SFRP2 | GO:0045600 | positive regulation of fat cell differentiation | 12055200 |
Tgene | SFRP2 | GO:0045892 | negative regulation of transcription, DNA-templated | 19095296 |
Tgene | SFRP2 | GO:0050680 | negative regulation of epithelial cell proliferation | 19095296 |
Tgene | SFRP2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 17471511 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0XN-01A | PPID | chr4 | 159640332 | - | SFRP2 | chr4 | 154702907 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000307720 | ENST00000274063 | PPID | chr4 | 159640332 | - | SFRP2 | chr4 | 154702907 | - |
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FusionProtFeatures for PPID_SFRP2 |
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Hgene | Tgene |
PPID | SFRP2 |
PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:11350175, PubMed:20676357).Proposed to act as a co-chaperone in HSP90 complexes such as inunligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thusestablishing distinct HSP90-co-chaperone-receptor complexes withthe potential to exert tissue-specific receptor activity control.May have a preference for estrogen receptor complexes and is notfound in glucocorticoid receptor complexes. May be involved incytoplasmic dynein-dependent movement of the receptor from thecytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling bypromoting the formation of the AHR:ARNT dimer; the function isindependent of HSP90 but requires the chaperone activity. Involvedin regulation of UV radiation-induced apoptosis. Promotes cellviability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.{ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779,ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}. (Microbial infection) May be involved in hepatitis Cvirus (HCV) replication and release. {ECO:0000269|PubMed:19932913,ECO:0000269|PubMed:21711559}. | Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPID_SFRP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPID_SFRP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPID | HSPA8, HSP90AB1, ESR1, FES, HSF1, HAP1, KAT7, NPM1, CSNK2B, PLK1, LNX1, NR3C1, NR3C2, AR, HSP90AA1, APP, FN1, GNB2L1, RPS3, HSPA1A, XRCC6, ILF2, TUBA1A, TUBB, S100A2, S100A6, S100A1, FBXO25, HPRT1, GCLC, PSAT1, BCL2, AHSA1, CDC37, GPALPP1, PTGES3, TRIM27, PCBP4, UNK, PKM, DNAJB1, OAT, STIP1, PSMD12, SF1, NTRK1, FGB, UROD, AEN, TMA16, CCDC83, AKIRIN2, AMTN, FGF9, IQCB1 | SFRP2 | WNT4, ARMC8, MAEA, MKLN1, RMND5A, RANBP9, PPP1CC, SFRP5, PPP1CA, PPP1CB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPID_SFRP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPID_SFRP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPID | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | SFRP2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | SFRP2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | SFRP2 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
Tgene | SFRP2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |