|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28192 |
FusionGeneSummary for PPID_SFRP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPID_SFRP2 | Fusion gene ID: 28192 | Hgene | Tgene | Gene symbol | PPID | SFRP2 | Gene ID | 5481 | 6423 |
| Gene name | peptidylprolyl isomerase D | secreted frizzled related protein 2 | |
| Synonyms | CYP-40|CYPD | FRP-2|SARP1|SDF-5 | |
| Cytomap | 4q32.1 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peptidyl-prolyl cis-trans isomerase D40 kDa peptidyl-prolyl cis-trans isomerase DPPIase Dcyclophilin 40cyclophilin Dcyclophilin-related proteinrotamase Dtesticular tissue protein Li 147 | secreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q08752 | Q96HF1 | |
| Ensembl transtripts involved in fusion gene | ENST00000307720, | ENST00000274063, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPID [Title/Abstract] AND SFRP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPID | GO:0000413 | protein peptidyl-prolyl isomerization | 20676357 |
| Hgene | PPID | GO:0061077 | chaperone-mediated protein folding | 11350175 |
| Hgene | PPID | GO:0065003 | protein-containing complex assembly | 18708059 |
| Tgene | SFRP2 | GO:0008284 | positive regulation of cell proliferation | 10980594 |
| Tgene | SFRP2 | GO:0008285 | negative regulation of cell proliferation | 20208569 |
| Tgene | SFRP2 | GO:0010719 | negative regulation of epithelial to mesenchymal transition | 19095296 |
| Tgene | SFRP2 | GO:0030178 | negative regulation of Wnt signaling pathway | 20208569 |
| Tgene | SFRP2 | GO:0030308 | negative regulation of cell growth | 20208569 |
| Tgene | SFRP2 | GO:0045600 | positive regulation of fat cell differentiation | 12055200 |
| Tgene | SFRP2 | GO:0045892 | negative regulation of transcription, DNA-templated | 19095296 |
| Tgene | SFRP2 | GO:0050680 | negative regulation of epithelial cell proliferation | 19095296 |
| Tgene | SFRP2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 17471511 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0XN-01A | PPID | chr4 | 159640332 | - | SFRP2 | chr4 | 154702907 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000307720 | ENST00000274063 | PPID | chr4 | 159640332 | - | SFRP2 | chr4 | 154702907 | - |
Top |
FusionProtFeatures for PPID_SFRP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPID | SFRP2 |
| PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:11350175, PubMed:20676357).Proposed to act as a co-chaperone in HSP90 complexes such as inunligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thusestablishing distinct HSP90-co-chaperone-receptor complexes withthe potential to exert tissue-specific receptor activity control.May have a preference for estrogen receptor complexes and is notfound in glucocorticoid receptor complexes. May be involved incytoplasmic dynein-dependent movement of the receptor from thecytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling bypromoting the formation of the AHR:ARNT dimer; the function isindependent of HSP90 but requires the chaperone activity. Involvedin regulation of UV radiation-induced apoptosis. Promotes cellviability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.{ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779,ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}. (Microbial infection) May be involved in hepatitis Cvirus (HCV) replication and release. {ECO:0000269|PubMed:19932913,ECO:0000269|PubMed:21711559}. | Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PPID_SFRP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PPID_SFRP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPID | HSPA8, HSP90AB1, ESR1, FES, HSF1, HAP1, KAT7, NPM1, CSNK2B, PLK1, LNX1, NR3C1, NR3C2, AR, HSP90AA1, APP, FN1, GNB2L1, RPS3, HSPA1A, XRCC6, ILF2, TUBA1A, TUBB, S100A2, S100A6, S100A1, FBXO25, HPRT1, GCLC, PSAT1, BCL2, AHSA1, CDC37, GPALPP1, PTGES3, TRIM27, PCBP4, UNK, PKM, DNAJB1, OAT, STIP1, PSMD12, SF1, NTRK1, FGB, UROD, AEN, TMA16, CCDC83, AKIRIN2, AMTN, FGF9, IQCB1 | SFRP2 | WNT4, ARMC8, MAEA, MKLN1, RMND5A, RANBP9, PPP1CC, SFRP5, PPP1CA, PPP1CB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPID_SFRP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PPID_SFRP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPID | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | SFRP2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | SFRP2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | SFRP2 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
| Tgene | SFRP2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|