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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28188

FusionGeneSummary for PPIA_OGDH

check button Fusion gene summary
Fusion gene informationFusion gene name: PPIA_OGDH
Fusion gene ID: 28188
HgeneTgene
Gene symbol

PPIA

OGDH

Gene ID

5478

4967

Gene namepeptidylprolyl isomerase Aoxoglutarate dehydrogenase
SynonymsCYPA|CYPH|HEL-S-69pAKGDH|E1k|OGDC
Cytomap

7p13

7p13

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase APPIase AT cell cyclophilincyclosporin A-binding proteinepididymis secretory sperm binding protein Li 69ppeptidylprolyl isomerase A (cyclophilin A)rotamase A2-oxoglutarate dehydrogenase, mitochondrial2-oxoglutarate dehydrogenase complex component E1OGDC-E1oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)oxoglutarate decarboxylaseoxoglutarate dehydrogenase (succinyl-transferring)testicular tis
Modification date2018052320180525
UniProtAcc

P62937

Q02218

Ensembl transtripts involved in fusion geneENST00000451562, ENST00000468812, 
ENST00000489459, ENST00000355968, 
ENST00000480603, 
ENST00000439616, 
ENST00000443864, ENST00000447398, 
ENST00000449767, ENST00000444676, 
ENST00000222673, ENST00000543843, 
ENST00000459672, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 4=100
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPIA [Title/Abstract] AND OGDH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPIA

GO:0000413

protein peptidyl-prolyl isomerization

14993672|20676357

TgeneOGDH

GO:0006103

2-oxoglutarate metabolic process

24495017|29211711

TgeneOGDH

GO:0006104

succinyl-CoA metabolic process

24495017|29211711

TgeneOGDH

GO:0106077

histone succinylation

29211711


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-29-1697-01APPIAchr7

44839473

+OGDHchr7

44733424

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000451562ENST00000439616PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000443864PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000447398PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000449767PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000444676PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000222673PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000543843PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000451562ENST00000459672PPIAchr7

44839473

+OGDHchr7

44733424

+
Frame-shiftENST00000468812ENST00000439616PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000443864PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000447398PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000449767PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000444676PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000222673PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000543843PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000468812ENST00000459672PPIAchr7

44839473

+OGDHchr7

44733424

+
Frame-shiftENST00000489459ENST00000439616PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000443864PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000447398PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000449767PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000444676PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000222673PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000543843PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000489459ENST00000459672PPIAchr7

44839473

+OGDHchr7

44733424

+
Frame-shiftENST00000355968ENST00000439616PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000443864PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000447398PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000449767PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000444676PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000222673PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000543843PPIAchr7

44839473

+OGDHchr7

44733424

+
5CDS-intronENST00000355968ENST00000459672PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-3CDSENST00000480603ENST00000439616PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000443864PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000447398PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000449767PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000444676PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000222673PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000543843PPIAchr7

44839473

+OGDHchr7

44733424

+
3UTR-intronENST00000480603ENST00000459672PPIAchr7

44839473

+OGDHchr7

44733424

+

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FusionProtFeatures for PPIA_OGDH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPIA

P62937

OGDH

Q02218

2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates thedecarboxylation of alpha-ketoglutarate (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex catalyzes the overallconversion of 2-oxoglutarate to succinyl-CoA and CO(2)(PubMed:24495017). The 2-oxoglutarate dehydrogenase complex ismainly active in the mitochondrion (PubMed:29211711). A fractionof the 2-oxoglutarate dehydrogenase complex also localizes in thenucleus and is required for lysine succinylation of histones:associates with KAT2A on chromatin and provides succinyl-CoA tohistone succinyltransferase KAT2A (PubMed:29211711).{ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:29211711}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPIA_OGDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPIA_OGDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPIAPRR13, JAK2, PRLR, S100A8, PRSS23, PPP3R1, PPP3CA, ITK, YY1, H2AFX, POU5F1, HDAC5, PCNA, ELAVL1, ARRB2, HNRNPA1, CHMP4A, CUL3, CUL4B, CDK2, CUL1, COPS5, NEDD8, CD99, USP4, AKT1, APP, IGBP1, TAGLN2, CPLX1, ENO1, RPA2, SNX3, RAD23B, SOD1, PTMA, RB1, LIG4, PAXIP1, FN1, VCAM1, ITGA4, RAD52, TERT, ESR1, SRPK2, SRPK1, RPL23A, HUWE1, FUS, TCF4, LNX1, NOTCH3, CUL7, OBSL1, NTRK1, CBFB, CFL1, CRIP1, DDX46, HEATR5A, HSPE1, KYNU, LDHA, LDHB, PCK2, PEBP1, PIN1, PIR, PSMD4, RAB10, EWSR1, N4BP2L2, ANXA1, ANXA7, ALDH7A1, LYST, GART, MYH9, RAB5C, CSDE1, RBM4, STX3, UBE2N, MKNK1, BCL7B, DNM1L, ZER1, ATP5S, PKN3, EPB41L4B, COPS7B, DCAF15, TMEM189, MCM2, U2AF2, RC3H1, ERRFI1, DUSP28, DUSP4, DUSP9, COX15, DLST, HSD17B10, PARK7, SDHA, SOAT1, VDAC1, TRIM25, G3BP1OGDHPLSCR1, DLD, DLST, USP13, ISG15, TSR1, PDHA1, PDHX, DLAT, PDHB, SSBP1, MRPL13, MRPL15, DHODH, MRPS2, MRPL41, SCFD1, CPSF7, MRPL38, MDM2, ENO1, MOV10, NXF1, UNK, ATP5H, COX5A, CYC1, NDUFS4, ATP1B3, NDUFS2, SUCLG1, SUCLG2, NTRK1, CAPZA2, HDAC6, EXOSC5, HSD17B10, TRIM25, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPIA_OGDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePPIAP62937DB11638ArtenimolPeptidyl-prolyl cis-trans isomerase Asmall moleculeapproved|investigational
HgenePPIAP62937DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Asmall moleculeapproved|investigational|vet_approved
TgeneOGDHQ02218DB00313Valproic Acid2-oxoglutarate dehydrogenase, mitochondrialsmall moleculeapproved|investigational
TgeneOGDHQ02218DB09092Xanthinol2-oxoglutarate dehydrogenase, mitochondrialsmall moleculeapproved|withdrawn

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RelatedDiseases for PPIA_OGDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPIAC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgenePPIAC0007137Squamous cell carcinoma1CTD_human
HgenePPIAC0026640Mouth Neoplasms1CTD_human
HgenePPIAC0027627Neoplasm Metastasis1CTD_human
HgenePPIAC0036341Schizophrenia1PSYGENET
HgenePPIAC0038356Stomach Neoplasms1CTD_human