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Fusion gene ID: 28132 |
FusionGeneSummary for PPFIA1_GSTP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PPFIA1_GSTP1 | Fusion gene ID: 28132 | Hgene | Tgene | Gene symbol | PPFIA1 | GSTP1 | Gene ID | 8500 | 2950 |
Gene name | PTPRF interacting protein alpha 1 | glutathione S-transferase pi 1 | |
Synonyms | LIP.1|LIP1|LIPRIN | DFN7|FAEES3|GST3|GSTP|HEL-S-22|PI | |
Cytomap | 11q13.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | liprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | glutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q13136 | P09211 | |
Ensembl transtripts involved in fusion gene | ENST00000253925, ENST00000389547, ENST00000530548, | ENST00000398606, ENST00000398603, ENST00000498765, | |
Fusion gene scores | * DoF score | 36 X 13 X 14=6552 | 3 X 2 X 3=18 |
# samples | 41 | 3 | |
** MAII score | log2(41/6552*10)=-3.99823954213556 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PPFIA1 [Title/Abstract] AND GSTP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GSTP1 | GO:0006469 | negative regulation of protein kinase activity | 16636664 |
Tgene | GSTP1 | GO:0006749 | glutathione metabolic process | 1540159 |
Tgene | GSTP1 | GO:0006805 | xenobiotic metabolic process | 1540159 |
Tgene | GSTP1 | GO:0009890 | negative regulation of biosynthetic process | 18962899 |
Tgene | GSTP1 | GO:0032691 | negative regulation of interleukin-1 beta production | 18962899 |
Tgene | GSTP1 | GO:0032720 | negative regulation of tumor necrosis factor production | 18962899 |
Tgene | GSTP1 | GO:0043407 | negative regulation of MAP kinase activity | 11408560 |
Tgene | GSTP1 | GO:0043508 | negative regulation of JUN kinase activity | 16636664 |
Tgene | GSTP1 | GO:0043651 | linoleic acid metabolic process | 16624487 |
Tgene | GSTP1 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process | 18962899 |
Tgene | GSTP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11408560 |
Tgene | GSTP1 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production | 18962899 |
Tgene | GSTP1 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 16636664 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-2V-A95S-01A | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000253925 | ENST00000398606 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
In-frame | ENST00000253925 | ENST00000398603 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
5CDS-3UTR | ENST00000253925 | ENST00000498765 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
In-frame | ENST00000389547 | ENST00000398606 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
In-frame | ENST00000389547 | ENST00000398603 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
5CDS-3UTR | ENST00000389547 | ENST00000498765 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
intron-3CDS | ENST00000530548 | ENST00000398606 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
intron-3CDS | ENST00000530548 | ENST00000398603 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
intron-3UTR | ENST00000530548 | ENST00000498765 | PPFIA1 | chr11 | 70118542 | + | GSTP1 | chr11 | 67352156 | + |
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FusionProtFeatures for PPFIA1_GSTP1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PPFIA1 | GSTP1 |
May regulate the disassembly of focal adhesions. Maylocalize receptor-like tyrosine phosphatases type 2A at specificsites on the plasma membrane, possibly regulating theirinteraction with the extracellular environment and theirassociation with substrates. {ECO:0000269|PubMed:7796809}. | Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles. Regulatesnegatively CDK5 activity via p25/p35 translocation to preventneurodegeneration. {ECO:0000269|PubMed:21668448}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 17_25 | 88 | 1597 | Compositional bias | Note=Poly-Gly |
Hgene | PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 17_25 | 88 | 1186 | Compositional bias | Note=Poly-Gly |
Tgene | >GSTP1 | chr11:70118542 | chr11:67352156 | ENST00000398606 | + | 2 | 7 | 83_204 | 48 | 211 | Domain | Note=GST C-terminal |
Tgene | >GSTP1 | chr11:70118542 | chr11:67352156 | ENST00000398606 | + | 2 | 7 | 52_53 | 48 | 211 | Region | Glutathione binding |
Tgene | >GSTP1 | chr11:70118542 | chr11:67352156 | ENST00000398606 | + | 2 | 7 | 65_66 | 48 | 211 | Region | Glutathione binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 1021_1050 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 176_214 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 249_521 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 34_141 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 623_669 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 847_871 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 1021_1050 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 176_214 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 249_521 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 34_141 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 623_669 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 847_871 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 1051_1120 | 88 | 1597 | Domain | SAM 3 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 878_944 | 88 | 1597 | Domain | SAM 1 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000253925 | + | 2 | 28 | 963_1027 | 88 | 1597 | Domain | SAM 2 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 1051_1120 | 88 | 1186 | Domain | SAM 3 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 878_944 | 88 | 1186 | Domain | SAM 1 |
Hgene | >PPFIA1 | chr11:70118542 | chr11:67352156 | ENST00000389547 | + | 2 | 26 | 963_1027 | 88 | 1186 | Domain | SAM 2 |
Tgene | GSTP1 | chr11:70118542 | chr11:67352156 | ENST00000398606 | + | 2 | 7 | 2_81 | 48 | 211 | Domain | Note=GST N-terminal |
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FusionGeneSequence for PPFIA1_GSTP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_GSTP1_ENST00000398606_chr11_67352156_+_251aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQLY GQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGG >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_GSTP1_ENST00000398603_chr11_67352156_+_215aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQLY GQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYISFADYNLLDLLLIHEVLAPGCLDAFPL >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_GSTP1_ENST00000398606_chr11_67352156_+_251aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQLY GQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGG >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_GSTP1_ENST00000398603_chr11_67352156_+_215aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQLY GQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYISFADYNLLDLLLIHEVLAPGCLDAFPL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_GSTP1_ENST00000398606_chr11_67352156_+_753nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGCTATAC GGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACC AACTATGAGGCGGGCAAGGATGACTATGTGAAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGC CTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_GSTP1_ENST00000398603_chr11_67352156_+_645nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGCTATAC GGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACC AACTATATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTG CTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTGAACCTCCCCATCAATGGC >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_GSTP1_ENST00000398606_chr11_67352156_+_753nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGCTATAC GGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACC AACTATGAGGCGGGCAAGGATGACTATGTGAAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGC CTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_GSTP1_ENST00000398603_chr11_67352156_+_645nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGCTATAC GGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACC AACTATATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTG CTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTGAACCTCCCCATCAATGGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_GSTP1_ENST00000398606_chr11_67352156_+_1051nt GCCGCGCAGCCGGGCCCGCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGC GGCGTGGGGCGGGCAGGCGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCG CGGAGCCTCCTCGCCCGCTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAG GTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACC GCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGC AGAGACAGCTCAACACGGCACTTCCACAGCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCA TCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTATGGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGG ACCTCCGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTGAAGGCACTGCCCGGGCAACTGAAGC CTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGCAAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACT TGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCA AGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGAGGGTTGGGGGGACTCTGAGCGG >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_GSTP1_ENST00000398603_chr11_67352156_+_933nt GCCGCGCAGCCGGGCCCGCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGC GGCGTGGGGCGGGCAGGCGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCG CGGAGCCTCCTCGCCCGCTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAG GTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACC GCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGC AGAGACAGCTCAACACGGCACTTCCACAGCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCA TCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTATGGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGG ACCTCCGCTGCAAATACATCTCCCTCATCTACACCAACTATATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGG TCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGG CCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGAGGGTTGGGGGGACTCTGAGCGGGAGGCAGAGTTTGCCTTC >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_GSTP1_ENST00000398606_chr11_67352156_+_1034nt GCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGCGGCGTGGGGCGGGCAGG CGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCGCGGAGCCTCCTCGCCCG CTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCC GGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTG AGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACG GCACTTCCACAGCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGC CGCACCCTTGGGCTCTATGGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATAC ATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTGAAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTG TCCCAGAACCAGGGAGGCAAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAG GTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTG GCCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGAGGGTTGGGGGGACTCTGAGCGGGAGGCAGAGTTTGCCTT >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_GSTP1_ENST00000398603_chr11_67352156_+_916nt GCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGCGGCGTGGGGCGGGCAGG CGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCGCGGAGCCTCCTCGCCCG CTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCC GGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTG AGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACG GCACTTCCACAGCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGC CGCACCCTTGGGCTCTATGGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATAC ATCTCCCTCATCTACACCAACTATATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGC CTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG AACCTCCCCATCAATGGCAACGGGAAACAGTGAGGGTTGGGGGGACTCTGAGCGGGAGGCAGAGTTTGCCTTCCTTTCTCCAGGACCAAT |
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FusionGenePPI for PPFIA1_GSTP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPFIA1 | GIT1, ERC2, PPP2R5D, TNNT1, MBIP, GRIP2, PTPRF, PTPRD, PTPRS, NCOA2, PPP2CA, PPP2R1A, PPFIA1, PPFIA2, ING4, PPP2CB, CUL2, AGTPBP1, CEP70, AMOT, LATS2, YWHAB, IKBKG, PSMC4, PSMD1, PSMD13, PSMD8, SPTAN1, DROSHA, NDN, AURKB, CDKN1A, CCNH, DTNB, FAM161A, TXLNA, BRCA1, GPS2, C16orf70, CYP4X1, NTRK1, OSBP, PPFIA3, PPFIBP1, PPFIBP2, CAGE1, TUBG1, XRCC1, GBA2, CDC5L, NF2, IL17RE, LLGL2, SERPINB2, STX11, EXOC8, TTC9B, CCDC120, TRIM25 | GSTP1 | FANCC, TGM2, PNO1, PTN, GSTP1, MAPK8, SIRT7, ISG15, CUL3, CUL2, CDK2, COPS5, TRAF2, MAPK1, MAP3K1, ACTA2, LIG4, FN1, VCAM1, ATF2, MLH1, ITGA4, SCAF1, FUS, KRT31, APPBP2, KRTAP10-7, KRTAP10-9, KRTAP10-3, NOTCH2NL, CUL7, HNRNPA1, NTRK1, GSTT2, GSTT2B, ACY1, GABPB1, ZNF518A, TXNL4A, RBMX, UBE2O, FOXD4, FBXL12, MCM2, PRDX6, EGFR, DLD, DLST, SOD1, UBE2A, DCAF4L2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPFIA1_GSTP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | GSTP1 | P09211 | DB00316 | Acetaminophen | Glutathione S-transferase P | small molecule | approved |
Tgene | GSTP1 | P09211 | DB00363 | Clozapine | Glutathione S-transferase P | small molecule | approved |
Tgene | GSTP1 | P09211 | DB01015 | Sulfamethoxazole | Glutathione S-transferase P | small molecule | approved |
Tgene | GSTP1 | P09211 | DB00903 | Etacrynic acid | Glutathione S-transferase P | small molecule | approved|investigational |
Tgene | GSTP1 | P09211 | DB04339 | Carbocisteine | Glutathione S-transferase P | small molecule | approved|investigational |
Tgene | GSTP1 | P09211 | DB09462 | Glycerin | Glutathione S-transferase P | small molecule | approved|investigational |
Tgene | GSTP1 | P09211 | DB00143 | Glutathione | Glutathione S-transferase P | small molecule | approved|investigational|nutraceutical |
Tgene | GSTP1 | P09211 | DB01242 | Clomipramine | Glutathione S-transferase P | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for PPFIA1_GSTP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GSTP1 | C0032927 | Precancerous Conditions | 5 | CTD_human |
Tgene | GSTP1 | C0033578 | Prostatic Neoplasms | 5 | CTD_human |
Tgene | GSTP1 | C0023904 | Liver Neoplasms, Experimental | 4 | CTD_human |
Tgene | GSTP1 | C0004096 | Asthma | 3 | CTD_human |
Tgene | GSTP1 | C0005695 | Bladder Neoplasm | 3 | CTD_human |
Tgene | GSTP1 | C0030567 | Parkinson Disease | 2 | CTD_human |
Tgene | GSTP1 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | GSTP1 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
Tgene | GSTP1 | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human |
Tgene | GSTP1 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Tgene | GSTP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | GSTP1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | GSTP1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | GSTP1 | C0007273 | Carotid Artery Diseases | 1 | CTD_human |
Tgene | GSTP1 | C0008625 | Chromosome Aberrations | 1 | CTD_human |
Tgene | GSTP1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | GSTP1 | C0013182 | Drug Allergy | 1 | CTD_human |
Tgene | GSTP1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | GSTP1 | C0019829 | Hodgkin Disease | 1 | CTD_human |
Tgene | GSTP1 | C0022650 | Kidney Calculi | 1 | CTD_human |
Tgene | GSTP1 | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | GSTP1 | C0023473 | Myeloid Leukemia, Chronic | 1 | CTD_human |
Tgene | GSTP1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | GSTP1 | C0027540 | Necrosis | 1 | CTD_human |
Tgene | GSTP1 | C0029463 | Osteosarcoma | 1 | CTD_human |
Tgene | GSTP1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Tgene | GSTP1 | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
Tgene | GSTP1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | GSTP1 | C0035234 | Respiratory Sounds | 1 | CTD_human |
Tgene | GSTP1 | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET |
Tgene | GSTP1 | C0042594 | Vestibular Diseases | 1 | CTD_human |
Tgene | GSTP1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | GSTP1 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | GSTP1 | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
Tgene | GSTP1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | GSTP1 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
Tgene | GSTP1 | C0600427 | Cocaine Dependence | 1 | PSYGENET |
Tgene | GSTP1 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Tgene | GSTP1 | C1261473 | Sarcoma | 1 | CTD_human |
Tgene | GSTP1 | C1456865 | Ureteral Calculi | 1 | CTD_human |
Tgene | GSTP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | GSTP1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | GSTP1 | C2609414 | Acute kidney injury | 1 | CTD_human |