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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2812

FusionGeneSummary for ARPC2_ARPC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARPC2_ARPC2
Fusion gene ID: 2812
HgeneTgene
Gene symbol

ARPC2

ARPC2

Gene ID

10109

10109

Gene nameactin related protein 2/3 complex subunit 2actin related protein 2/3 complex subunit 2
SynonymsARC34|PNAS-139|PRO2446|p34-ArcARC34|PNAS-139|PRO2446|p34-Arc
Cytomap

2q35

2q35

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53eactin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53e
Modification date2018052320180523
UniProtAcc

O15144

O15144

Ensembl transtripts involved in fusion geneENST00000315717, ENST00000295685, 
ENST00000477992, 
ENST00000315717, 
ENST00000295685, ENST00000477992, 
Fusion gene scores* DoF score5 X 7 X 2=709 X 10 X 4=360
# samples 711
** MAII scorelog2(7/70*10)=0log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARPC2 [Title/Abstract] AND ARPC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARPC2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539

TgeneARPC2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB242231ARPC2chr2

219118749

-ARPC2chr2

219118679

+
ChiTaRS3.1BE073187ARPC2chr2

219118966

+ARPC2chr2

219093522

+
ChiTaRS3.1CB321859ARPC2chr2

219114564

-ARPC2chr2

219118619

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000315717ENST00000315717ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000315717ENST00000295685ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000315717ENST00000477992ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000295685ENST00000315717ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000295685ENST00000295685ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000295685ENST00000477992ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000315717ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000295685ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000477992ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3CDSENST00000315717ENST00000315717ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000315717ENST00000295685ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-intronENST00000315717ENST00000477992ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000295685ENST00000315717ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000295685ENST00000295685ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-intronENST00000295685ENST00000477992ARPC2chr2

219118966

+ARPC2chr2

219093522

+
intron-3CDSENST00000477992ENST00000315717ARPC2chr2

219118966

+ARPC2chr2

219093522

+
intron-3CDSENST00000477992ENST00000295685ARPC2chr2

219118966

+ARPC2chr2

219093522

+
intron-intronENST00000477992ENST00000477992ARPC2chr2

219118966

+ARPC2chr2

219093522

+
In-frameENST00000315717ENST00000315717ARPC2chr2

219114564

-ARPC2chr2

219118619

+
Frame-shiftENST00000315717ENST00000295685ARPC2chr2

219114564

-ARPC2chr2

219118619

+
5CDS-3UTRENST00000315717ENST00000477992ARPC2chr2

219114564

-ARPC2chr2

219118619

+
In-frameENST00000295685ENST00000315717ARPC2chr2

219114564

-ARPC2chr2

219118619

+
Frame-shiftENST00000295685ENST00000295685ARPC2chr2

219114564

-ARPC2chr2

219118619

+
5CDS-3UTRENST00000295685ENST00000477992ARPC2chr2

219114564

-ARPC2chr2

219118619

+
3UTR-3CDSENST00000477992ENST00000315717ARPC2chr2

219114564

-ARPC2chr2

219118619

+
3UTR-3CDSENST00000477992ENST00000295685ARPC2chr2

219114564

-ARPC2chr2

219118619

+
3UTR-3UTRENST00000477992ENST00000477992ARPC2chr2

219114564

-ARPC2chr2

219118619

+

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FusionProtFeatures for ARPC2_ARPC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARPC2

O15144

ARPC2

O15144

Functions as actin-binding component of the Arp2/3complex which is involved in regulation of actin polymerizationand together with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the mother actin filament. Functions as actin-binding component of the Arp2/3complex which is involved in regulation of actin polymerizationand together with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the mother actin filament.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARPC2_ARPC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARPC2_ARPC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARPC2_ARPC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARPC2_ARPC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARPC2C0009324Ulcerative Colitis1CTD_human
TgeneARPC2C0009324Ulcerative Colitis1CTD_human