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Fusion gene ID: 28054 |
FusionGeneSummary for POU2F1_MAEL |
Fusion gene summary |
Fusion gene information | Fusion gene name: POU2F1_MAEL | Fusion gene ID: 28054 | Hgene | Tgene | Gene symbol | POU2F1 | MAEL | Gene ID | 5451 | 84944 |
Gene name | POU class 2 homeobox 1 | maelstrom spermatogenic transposon silencer | |
Synonyms | OCT1|OTF1|oct-1B | CT128|SPATA35 | |
Cytomap | 1q24.2 | 1q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | POU domain, class 2, transcription factor 1NF-A1OTF-1Octamer-binding transcription factor-1oct-1octamer-binding protein 1octamer-binding transcription factor 1 | protein maelstrom homologcancer/testis antigen 128maelstrom homologspermatogenesis associated 35testicular tissue protein Li 116 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P14859 | Q96JY0 | |
Ensembl transtripts involved in fusion gene | ENST00000367866, ENST00000452019, ENST00000429375, ENST00000367865, ENST00000541643, ENST00000420254, ENST00000367862, | ENST00000367872, ENST00000367870, ENST00000491055, | |
Fusion gene scores | * DoF score | 9 X 5 X 8=360 | 3 X 4 X 4=48 |
# samples | 10 | 4 | |
** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: POU2F1 [Title/Abstract] AND MAEL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | POU2F1 | GO:0045892 | negative regulation of transcription, DNA-templated | 11891224|11997177 |
Hgene | POU2F1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15252056 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-2H-A9GG-01A | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
TCGA | LD | OV | TCGA-13-1405-01A | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000367866 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
In-frame | ENST00000367866 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5CDS-3UTR | ENST00000367866 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3CDS | ENST00000452019 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3CDS | ENST00000452019 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3UTR | ENST00000452019 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
In-frame | ENST00000429375 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
In-frame | ENST00000429375 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5CDS-3UTR | ENST00000429375 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
3UTR-3CDS | ENST00000367865 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
3UTR-3CDS | ENST00000367865 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
3UTR-3UTR | ENST00000367865 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3CDS | ENST00000541643 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3CDS | ENST00000541643 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3UTR | ENST00000541643 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3CDS | ENST00000420254 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3CDS | ENST00000420254 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
5UTR-3UTR | ENST00000420254 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
intron-3CDS | ENST00000367862 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
intron-3CDS | ENST00000367862 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
intron-3UTR | ENST00000367862 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166973417 | + |
Frame-shift | ENST00000367866 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
Frame-shift | ENST00000367866 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5CDS-3UTR | ENST00000367866 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3CDS | ENST00000452019 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3CDS | ENST00000452019 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3UTR | ENST00000452019 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
Frame-shift | ENST00000429375 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
Frame-shift | ENST00000429375 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5CDS-3UTR | ENST00000429375 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
3UTR-3CDS | ENST00000367865 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
3UTR-3CDS | ENST00000367865 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
3UTR-3UTR | ENST00000367865 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3CDS | ENST00000541643 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3CDS | ENST00000541643 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3UTR | ENST00000541643 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3CDS | ENST00000420254 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3CDS | ENST00000420254 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
5UTR-3UTR | ENST00000420254 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
intron-3CDS | ENST00000367862 | ENST00000367872 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
intron-3CDS | ENST00000367862 | ENST00000367870 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
intron-3UTR | ENST00000367862 | ENST00000491055 | POU2F1 | chr1 | 167190195 | + | MAEL | chr1 | 166960615 | + |
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FusionProtFeatures for POU2F1_MAEL |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
POU2F1 | MAEL |
Plays a central role during spermatogenesis byrepressing transposable elements and preventing theirmobilization, which is essential for the germline integrity. Actsvia the piRNA metabolic process, which mediates the repression oftransposable elements during meiosis by forming complexes composedof piRNAs and Piwi proteins and governs the methylation andsubsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolicprocess. Required for the localization of germ-cell factors to themeiotic nuage (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000367862 | + | 1 | 16 | 379_438 | -79 | 756 | DNA binding | Homeobox |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000420254 | + | 1 | 17 | 379_438 | -37 | 654 | DNA binding | Homeobox |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000429375 | + | 1 | 15 | 379_438 | 20 | 704 | DNA binding | Homeobox |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000541643 | + | 1 | 17 | 379_438 | -37 | 744 | DNA binding | Homeobox |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000367862 | + | 1 | 16 | 280_354 | -79 | 756 | Domain | POU-specific |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000420254 | + | 1 | 17 | 280_354 | -37 | 654 | Domain | POU-specific |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000429375 | + | 1 | 15 | 280_354 | 20 | 704 | Domain | POU-specific |
Hgene | >POU2F1 | chr1:167190195 | chr1:166973417 | ENST00000541643 | + | 1 | 17 | 280_354 | -37 | 744 | Domain | POU-specific |
Tgene | MAEL | chr1:167190195 | chr1:166973417 | ENST00000367870 | + | 3 | 11 | 4_73 | 143 | 404 | DNA binding | Note=HMG box |
Tgene | MAEL | chr1:167190195 | chr1:166973417 | ENST00000367872 | + | 4 | 12 | 4_73 | 174 | 435 | DNA binding | Note=HMG box |
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FusionGeneSequence for POU2F1_MAEL |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_POU2F1_ENST00000367866_chr1_167190195_+_MAEL_ENST00000367872_chr1_166973417_+_281aa MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK >In-frame_POU2F1_ENST00000367866_chr1_167190195_+_MAEL_ENST00000367870_chr1_166973417_+_281aa MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_MAEL_ENST00000367872_chr1_166973417_+_281aa MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_MAEL_ENST00000367870_chr1_166973417_+_281aa MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_POU2F1_ENST00000367866_chr1_167190195_+_MAEL_ENST00000367872_chr1_166973417_+_843nt ATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCA AATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTAC TGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACT GTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATG TGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTAC TGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTG ACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAG GAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACC CGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAA >In-frame_POU2F1_ENST00000367866_chr1_167190195_+_MAEL_ENST00000367870_chr1_166973417_+_843nt ATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCA AATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTAC TGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACT GTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATG TGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTAC TGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTG ACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAG GAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACC CGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAA >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_MAEL_ENST00000367872_chr1_166973417_+_843nt ATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCA AATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTAC TGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACT GTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATG TGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTAC TGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTG ACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAG GAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACC CGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAA >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_MAEL_ENST00000367870_chr1_166973417_+_843nt ATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCA AATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTAC TGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACT GTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATG TGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTAC TGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTG ACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAG GAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACC CGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_POU2F1_ENST00000367866_chr1_167190195_+_MAEL_ENST00000367872_chr1_166973417_+_1271nt GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAAC CAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACC AGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGG ATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACA AGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCC ACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTG GATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCC ATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCC AATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCT TCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCAC ATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCT TGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAA AACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGATAATAAAGGTATTGAATATCTGTTATGAA >In-frame_POU2F1_ENST00000367866_chr1_167190195_+_MAEL_ENST00000367870_chr1_166973417_+_1234nt GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAAC CAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACC AGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGG ATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACA AGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCC ACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTG GATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCC ATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCC AATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCT TCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCAC ATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCT TGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAA >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_MAEL_ENST00000367872_chr1_166973417_+_1209nt ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCC TATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACC TATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACT TCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGT GGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGAT TGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAA TAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTC TAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGG AATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTC CCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTT CTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGAT TTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATC ATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGAT >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_MAEL_ENST00000367870_chr1_166973417_+_1172nt ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCC TATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACC TATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACT TCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGT GGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGAT TGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAA TAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTC TAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGG AATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTC CCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTT CTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGAT TTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATC ATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGAT |
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FusionGenePPI for POU2F1_MAEL |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
POU2F1 | GAPDH, NPAT, STIP1, NCOR2, ESR1, RXRA, RARA, THRA, AR, PGR, NR3C1, POU2AF1, MNAT1, XRCC6, XRCC5, SNAPC4, SP1, POU2F1, HCFC1, TXNRD1, VDR, TBP, TNF, RELA, BRCA1, BRD7, PRKACA, PRKDC, HDAC1, CEBPE, TLX2, HOXC9, IRF9, HOXB13, CREB1, STAT5B, PBX1, PKNOX1, HMGA1, LMNB1, CDK11B, HOXC4, APP, SPTBN1, HSPA8, PLK3, SP4, POGZ, MAGEA10, PARP1, TEAD2, FOXC1, FOXC2, FOXS1, FGB, PRR20E, TRIM25 | MAEL | NUDC, PABPC1, YBX1, KHSRP, SYNCRIP, EIF4A1, EIF3F, ELAVL1, DDX39A, EIF4B, HNRNPA1, HNRNPA2B1, FUBP1, DDX1, DDX3X |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POU2F1_MAEL |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POU2F1_MAEL |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |