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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28044

FusionGeneSummary for POSTN_POSTN

check button Fusion gene summary
Fusion gene informationFusion gene name: POSTN_POSTN
Fusion gene ID: 28044
HgeneTgene
Gene symbol

POSTN

POSTN

Gene ID

10631

10631

Gene nameperiostinperiostin
SynonymsOSF-2|OSF2|PDLPOSTN|PNOSF-2|OSF2|PDLPOSTN|PN
Cytomap

13q13.3

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionperiostinosteoblast specific factor 2 (fasciclin I-like)periodontal ligament-specific periostinperiostin, osteoblast specific factorperiostinosteoblast specific factor 2 (fasciclin I-like)periodontal ligament-specific periostinperiostin, osteoblast specific factor
Modification date2018052320180523
UniProtAcc

Q15063

Q15063

Ensembl transtripts involved in fusion geneENST00000541179, ENST00000379749, 
ENST00000379747, ENST00000379743, 
ENST00000379742, ENST00000541481, 
ENST00000497145, 
ENST00000541179, 
ENST00000379749, ENST00000379747, 
ENST00000379743, ENST00000379742, 
ENST00000541481, ENST00000497145, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 7 X 3=147
# samples 49
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POSTN [Title/Abstract] AND POSTN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOSTN

GO:0007155

cell adhesion

12235007

HgenePOSTN

GO:0071307

cellular response to vitamin K

18450759

TgenePOSTN

GO:0007155

cell adhesion

12235007

TgenePOSTN

GO:0071307

cellular response to vitamin K

18450759


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI751337POSTNchr13

38153029

+POSTNchr13

38145534

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000541179ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541179ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541179ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541179ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000541179ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000541179ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000541179ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379749ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379749ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379749ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379749ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379749ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379749ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000379749ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379747ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379747ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379747ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379747ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379747ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379747ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000379747ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379743ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379743ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379743ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379743ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379743ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379743ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000379743ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379742ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379742ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379742ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000379742ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379742ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000379742ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000379742ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541481ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541481ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541481ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000541481ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000541481ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000541481ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000541481ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000497145ENST00000541179POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000497145ENST00000379749POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000497145ENST00000379747POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-3CDSENST00000497145ENST00000379743POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000497145ENST00000379742POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-intronENST00000497145ENST00000541481POSTNchr13

38153029

+POSTNchr13

38145534

-
intron-5UTRENST00000497145ENST00000497145POSTNchr13

38153029

+POSTNchr13

38145534

-

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FusionProtFeatures for POSTN_POSTN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POSTN

Q15063

POSTN

Q15063


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for POSTN_POSTN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for POSTN_POSTN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POSTN_POSTN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POSTN_POSTN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePOSTNC0006287Bronchopulmonary Dysplasia1CTD_human
HgenePOSTNC0009404Colorectal Neoplasms1CTD_human
HgenePOSTNC0013182Drug Allergy1CTD_human
HgenePOSTNC0013264Muscular Dystrophy, Duchenne1CTD_human
HgenePOSTNC1319853Asthma, Aspirin-Induced1CTD_human
TgenePOSTNC0006287Bronchopulmonary Dysplasia1CTD_human
TgenePOSTNC0009404Colorectal Neoplasms1CTD_human
TgenePOSTNC0013182Drug Allergy1CTD_human
TgenePOSTNC0013264Muscular Dystrophy, Duchenne1CTD_human
TgenePOSTNC1319853Asthma, Aspirin-Induced1CTD_human