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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28012

FusionGeneSummary for POM121_POM121

check button Fusion gene summary
Fusion gene informationFusion gene name: POM121_POM121
Fusion gene ID: 28012
HgeneTgene
Gene symbol

POM121

POM121

Gene ID

22932

22932

Gene namePOM121 and ZP3 fusionPOM121 and ZP3 fusion
SynonymsPOM-ZP3|POM121POM-ZP3|POM121
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
DescriptionPOM121 and ZP3 fusion proteinPOM (POM121 homolog, rat) and ZP3 fusionPOM (POM121 rat homolog) and ZP3 fusionPOM-ZP3 fusion proteinPOM121/ZP3 fusion proteinPOM121 and ZP3 fusion proteinPOM (POM121 homolog, rat) and ZP3 fusionPOM (POM121 rat homolog) and ZP3 fusionPOM-ZP3 fusion proteinPOM121/ZP3 fusion protein
Modification date2018052320180523
UniProtAcc

Q96HA1

Q96HA1

Ensembl transtripts involved in fusion geneENST00000257622, ENST00000446813, 
ENST00000395270, ENST00000358357, 
ENST00000434423, 
ENST00000257622, 
ENST00000446813, ENST00000395270, 
ENST00000358357, ENST00000434423, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: POM121 [Title/Abstract] AND POM121 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM715257POM121chr7

72383860

-POM121chr7

72385290

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000257622ENST00000257622POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000257622ENST00000446813POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000257622ENST00000395270POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000257622ENST00000358357POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000257622ENST00000434423POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000446813ENST00000257622POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000446813ENST00000446813POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000446813ENST00000395270POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000446813ENST00000358357POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000446813ENST00000434423POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000395270ENST00000257622POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000395270ENST00000446813POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000395270ENST00000395270POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000395270ENST00000358357POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000395270ENST00000434423POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000358357ENST00000257622POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000358357ENST00000446813POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000358357ENST00000395270POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000358357ENST00000358357POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000358357ENST00000434423POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000434423ENST00000257622POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000434423ENST00000446813POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000434423ENST00000395270POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000434423ENST00000358357POM121chr7

72383860

-POM121chr7

72385290

-
intron-intronENST00000434423ENST00000434423POM121chr7

72383860

-POM121chr7

72385290

-

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FusionProtFeatures for POM121_POM121


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POM121

Q96HA1

POM121

Q96HA1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for POM121_POM121


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for POM121_POM121


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POM121_POM121


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POM121_POM121


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource