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Fusion gene ID: 28005 |
FusionGeneSummary for POLR3H_FAM87B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR3H_FAM87B | Fusion gene ID: 28005 | Hgene | Tgene | Gene symbol | POLR3H | FAM87B | Gene ID | 171568 | 400728 |
| Gene name | RNA polymerase III subunit H | family with sequence similarity 87 member B | |
| Synonyms | RPC22.9|RPC8 | - | |
| Cytomap | 22q13.2 | 1p36.33 | |
| Type of gene | protein-coding | ncRNA | |
| Description | DNA-directed RNA polymerase III subunit RPC8DNA-directed RNA polymerase III subunit 22.9 kDa polypeptideDNA-directed RNA polymerase III subunit HRNA nucleotidyltransferase (DNA-directed)RNA polymerase III subunit C8polymerase (RNA) III (DNA directed) | - | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q9Y535 | ||
| Ensembl transtripts involved in fusion gene | ENST00000396504, ENST00000355209, ENST00000337566, ENST00000407461, ENST00000420561, | ENST00000326734, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: POLR3H [Title/Abstract] AND FAM87B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLR3H | GO:0006139 | nucleobase-containing compound metabolic process | 12391170 |
| Hgene | POLR3H | GO:0006383 | transcription by RNA polymerase III | 12391170 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A8NE-01A | POLR3H | chr22 | 41936703 | - | FAM87B | chr1 | 754103 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000396504 | ENST00000326734 | POLR3H | chr22 | 41936703 | - | FAM87B | chr1 | 754103 | + |
| 5CDS-3UTR | ENST00000355209 | ENST00000326734 | POLR3H | chr22 | 41936703 | - | FAM87B | chr1 | 754103 | + |
| 5CDS-3UTR | ENST00000337566 | ENST00000326734 | POLR3H | chr22 | 41936703 | - | FAM87B | chr1 | 754103 | + |
| 5CDS-3UTR | ENST00000407461 | ENST00000326734 | POLR3H | chr22 | 41936703 | - | FAM87B | chr1 | 754103 | + |
| intron-3UTR | ENST00000420561 | ENST00000326734 | POLR3H | chr22 | 41936703 | - | FAM87B | chr1 | 754103 | + |
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FusionProtFeatures for POLR3H_FAM87B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR3H | FAM87B |
| DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Specific peripheric component of RNA polymerase IIIwhich synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays akey role in sensing and limiting infection by intracellularbacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensorinvolved in innate immune response. Can sense non-self dsDNA thatserves as template for transcription into dsRNA. The non-self RNApolymerase III transcripts, such as Epstein-Barr virus-encodedRNAs (EBERs) induce type I interferon and NF- Kappa-B through theRIG-I pathway (By similarity). {ECO:0000250,ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POLR3H_FAM87B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for POLR3H_FAM87B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POLR3H | POLR3D, RAE1, POLR3B, POLR3C, POLR3E, POLR3A, POLR2H, POLR3G, PCBP2, HSPA5, POLR1D, CDC42EP4, YWHAE, CRCP, POLR2E, POLR1C, HMG20B, GPN3, CDK2, LOC101060521, POLR3F, POLR2F, POLR3GL, ELAVL2 | FAM87B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR3H_FAM87B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR3H_FAM87B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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