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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 27940

FusionGeneSummary for POLK_ANKDD1B

check button Fusion gene summary
Fusion gene informationFusion gene name: POLK_ANKDD1B
Fusion gene ID: 27940
HgeneTgene
Gene symbol

POLK

ANKDD1B

Gene ID

51426

728780

Gene nameDNA polymerase kappaankyrin repeat and death domain containing 1B
SynonymsDINB1|DINP|POLQ-
Cytomap

5q13.3

5q13.3

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase kappapolymerase (DNA directed) kappaankyrin repeat and death domain-containing protein 1Bankyrin repeat and death domain-containing protein ENSP00000345065
Modification date2018052320180329
UniProtAcc

Q9UBT6

A6NHY2

Ensembl transtripts involved in fusion geneENST00000241436, ENST00000352007, 
ENST00000506928, ENST00000515295, 
ENST00000508526, ENST00000504026, 
ENST00000380481, 
ENST00000601380, 
ENST00000506596, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: POLK [Title/Abstract] AND ANKDD1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLK

GO:0006281

DNA repair

28297716

HgenePOLK

GO:0006974

cellular response to DNA damage stimulus

28297716

HgenePOLK

GO:0034644

cellular response to UV

28297716

HgenePOLK

GO:0042276

error-prone translesion synthesis

28297716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CD-8526-01APOLKchr5

74848416

+ANKDD1Bchr5

74948967

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000241436ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5CDS-3UTRENST00000241436ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
In-frameENST00000352007ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5CDS-3UTRENST00000352007ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
3UTR-3CDSENST00000506928ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
3UTR-3UTRENST00000506928ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
In-frameENST00000515295ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5CDS-3UTRENST00000515295ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
In-frameENST00000508526ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5CDS-3UTRENST00000508526ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
In-frameENST00000504026ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5CDS-3UTRENST00000504026ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5UTR-3CDSENST00000380481ENST00000601380POLKchr5

74848416

+ANKDD1Bchr5

74948967

+
5UTR-3UTRENST00000380481ENST00000506596POLKchr5

74848416

+ANKDD1Bchr5

74948967

+

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FusionProtFeatures for POLK_ANKDD1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLK

Q9UBT6

ANKDD1B

A6NHY2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614427_515266529DomainDeath
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614267_296266529RepeatNote=ANK 7
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614300_329266529RepeatNote=ANK 8
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614333_362266529RepeatNote=ANK 9
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614366_395266529RepeatNote=ANK 10

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLKchr5:74848416chr5:74948967ENST00000241436+315103_35885871DomainNote=UmuC
HgenePOLKchr5:74848416chr5:74948967ENST00000352007+310103_35885673DomainNote=UmuC
HgenePOLKchr5:74848416chr5:74948967ENST00000380481+215103_358-43781DomainNote=UmuC
HgenePOLKchr5:74848416chr5:74948967ENST00000504026+212103_35885445DomainNote=UmuC
HgenePOLKchr5:74848416chr5:74948967ENST00000508526+29103_35885673DomainNote=UmuC
HgenePOLKchr5:74848416chr5:74948967ENST00000515295+210103_35885473DomainNote=UmuC
HgenePOLKchr5:74848416chr5:74948967ENST00000241436+315621_64785871Zinc fingerNote=UBZ-type 1
HgenePOLKchr5:74848416chr5:74948967ENST00000241436+315776_80285871Zinc fingerNote=UBZ-type 2
HgenePOLKchr5:74848416chr5:74948967ENST00000352007+310621_64785673Zinc fingerNote=UBZ-type 1
HgenePOLKchr5:74848416chr5:74948967ENST00000352007+310776_80285673Zinc fingerNote=UBZ-type 2
HgenePOLKchr5:74848416chr5:74948967ENST00000380481+215621_647-43781Zinc fingerNote=UBZ-type 1
HgenePOLKchr5:74848416chr5:74948967ENST00000380481+215776_802-43781Zinc fingerNote=UBZ-type 2
HgenePOLKchr5:74848416chr5:74948967ENST00000504026+212621_64785445Zinc fingerNote=UBZ-type 1
HgenePOLKchr5:74848416chr5:74948967ENST00000504026+212776_80285445Zinc fingerNote=UBZ-type 2
HgenePOLKchr5:74848416chr5:74948967ENST00000508526+29621_64785673Zinc fingerNote=UBZ-type 1
HgenePOLKchr5:74848416chr5:74948967ENST00000508526+29776_80285673Zinc fingerNote=UBZ-type 2
HgenePOLKchr5:74848416chr5:74948967ENST00000515295+210621_64785473Zinc fingerNote=UBZ-type 1
HgenePOLKchr5:74848416chr5:74948967ENST00000515295+210776_80285473Zinc fingerNote=UBZ-type 2
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614100_129266529RepeatNote=ANK 2
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614133_162266529RepeatNote=ANK 3
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614166_197266529RepeatNote=ANK 4
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614201_230266529RepeatNote=ANK 5
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+614234_263266529RepeatNote=ANK 6
TgeneANKDD1Bchr5:74848416chr5:74948967ENST00000601380+61467_96266529RepeatNote=ANK 1


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FusionGeneSequence for POLK_ANKDD1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_POLK_ENST00000241436_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_348aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQLNISS
LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLK
AVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNF

>In-frame_POLK_ENST00000352007_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_348aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQLNISS
LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLK
AVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNF

>In-frame_POLK_ENST00000515295_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_348aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQLNISS
LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLK
AVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNF

>In-frame_POLK_ENST00000508526_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_348aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQLNISS
LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLK
AVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNF

>In-frame_POLK_ENST00000504026_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_348aa
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQLNISS
LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLK
AVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQLKANEWQRLARSWNF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_POLK_ENST00000241436_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1044nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT

>In-frame_POLK_ENST00000352007_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1044nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT

>In-frame_POLK_ENST00000515295_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1044nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT

>In-frame_POLK_ENST00000508526_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1044nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT

>In-frame_POLK_ENST00000504026_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1044nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT


* Fusion transcript sequences (Full-length transcript).
>In-frame_POLK_ENST00000241436_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_2022nt
TACCTCCGGCTCTCCCGGGTGACGACGGGTAGAAAAGCAGGAGGAGCGGAGAAAGGAGAGGGCGGGGTAGGGATGCAGCTGTGCTGCATT
CTGGGAAGGGCGTTGGTCCGTCGCTCGCGCAGCCTCCTGGGAGTTGTAGTCGCGATCCTGAGGTAACGGATAAGTTTATACCATGGATAG
CACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGATTAGATAA
AGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTCAACCAACG
AATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGTTTGCAGAT
AGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAGGAGTCCCC
TCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAATCAGAAGCA
GCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAGGCTGTTGA
CAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGATACTACGC
CTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAGACCAGACA
CATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTTACAGATGA
CCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTACACGGGAC
CCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACTCGTCATTT
CAAAAGCAAAACTGACTCAAACTCCAAGAAATGTGTAGTTTCATAAATGCCTAAAGAAATTGTATTTACATGATTTTCCACTCAGCATTC
AGTTCTTTTAATGCCATAAATTTCTTCTAGCAGTAGCACTGATTTTCAACTATGATGATGGTGGTGACAGGGAACTCTAACAGATGAAAG
AAGAGTAATACCATGATACTTTTCAACCACTAAAAAGTCAAATATAGTTTTTTTTGCTGAGGGCAAGTTGTATGTGATTTTCCCATTTCT
ATCAATCATTTGATGTAATCCATGTAATAAGATAATCTAGGACGGTTTTGTATGTCATGTTTTTTTAAAAAACTCATGGGAGCAGCATCA
TGGTACAGTAAAAAAACAAGGGTTTTTATAATAGACAAATATGGTTTTGAACTTGGTTTTGCCACTTATTAGATGTGAACCTTTGGGCAT
GTTAATGTTGTTTACGTTCTTAGATCTTCAGTTTCCTTCTCTATAAACTGGGAGAGATGTCTATTTAATCCATAGGGTTGGAATGAAGAT
GAAGGGAAAATGCCTGTGTAGCCTCACGCCCATAGTACGGAAATCAACTGCTATTTCTCTTTCAGTAAGAGAAACTGGGTTTGGAATTTA
TAGTCATTGTTGACTTTAAATCACACATTTTGTGTAATATATTACTTAGGAAAGACCAGAAGTATGTACACCATTTTTTTTTTTTTTTAA
ATCTCTTGGTGATGTAATTACAGATGATTATTTTCTTTGTACTTTTGGGTACATTCCATTCTTTTTTTCACAAAGAACATGCATTATTTT

>In-frame_POLK_ENST00000352007_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1946nt
AGCTGTGCTGCATTCTGGGAAGGGCGTTGGTCCGTCGCTCGCGCAGCCTCCTGGGAGTTGTAGTCGCGATCCTGAGGTAACGGATAAGTT
TATACCATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATG
GAAGGATTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAG
CAAGTCAACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATC
AGTAGTTTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAA
CCTAAGGAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATC
TTAAATCAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGAC
TTGAAGGCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCA
GAGAGATACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGT
CTGGAGACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGG
AACTTTACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATC
TGGCTACACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAA
AAGACTCGTCATTTCAAAAGCAAAACTGACTCAAACTCCAAGAAATGTGTAGTTTCATAAATGCCTAAAGAAATTGTATTTACATGATTT
TCCACTCAGCATTCAGTTCTTTTAATGCCATAAATTTCTTCTAGCAGTAGCACTGATTTTCAACTATGATGATGGTGGTGACAGGGAACT
CTAACAGATGAAAGAAGAGTAATACCATGATACTTTTCAACCACTAAAAAGTCAAATATAGTTTTTTTTGCTGAGGGCAAGTTGTATGTG
ATTTTCCCATTTCTATCAATCATTTGATGTAATCCATGTAATAAGATAATCTAGGACGGTTTTGTATGTCATGTTTTTTTAAAAAACTCA
TGGGAGCAGCATCATGGTACAGTAAAAAAACAAGGGTTTTTATAATAGACAAATATGGTTTTGAACTTGGTTTTGCCACTTATTAGATGT
GAACCTTTGGGCATGTTAATGTTGTTTACGTTCTTAGATCTTCAGTTTCCTTCTCTATAAACTGGGAGAGATGTCTATTTAATCCATAGG
GTTGGAATGAAGATGAAGGGAAAATGCCTGTGTAGCCTCACGCCCATAGTACGGAAATCAACTGCTATTTCTCTTTCAGTAAGAGAAACT
GGGTTTGGAATTTATAGTCATTGTTGACTTTAAATCACACATTTTGTGTAATATATTACTTAGGAAAGACCAGAAGTATGTACACCATTT
TTTTTTTTTTTTAAATCTCTTGGTGATGTAATTACAGATGATTATTTTCTTTGTACTTTTGGGTACATTCCATTCTTTTTTTCACAAAGA

>In-frame_POLK_ENST00000515295_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1863nt
ATAAGTTTATACCATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGC
AGGAATGGAAGGATTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAA
AGAAAAGCAAGTCAACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCT
CAATATCAGTAGTTTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAA
AGTGGAACCTAAGGAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATAT
TGACATCTTAAATCAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGG
CTGTGACTTGAAGGCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCAT
TAAAGCAGAGAGATACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGA
TCACAGTCTGGAGACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCG
TTCGTGGAACTTTACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCT
GCTTATCTGGCTACACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACT
AGCTGAAAAGACTCGTCATTTCAAAAGCAAAACTGACTCAAACTCCAAGAAATGTGTAGTTTCATAAATGCCTAAAGAAATTGTATTTAC
ATGATTTTCCACTCAGCATTCAGTTCTTTTAATGCCATAAATTTCTTCTAGCAGTAGCACTGATTTTCAACTATGATGATGGTGGTGACA
GGGAACTCTAACAGATGAAAGAAGAGTAATACCATGATACTTTTCAACCACTAAAAAGTCAAATATAGTTTTTTTTGCTGAGGGCAAGTT
GTATGTGATTTTCCCATTTCTATCAATCATTTGATGTAATCCATGTAATAAGATAATCTAGGACGGTTTTGTATGTCATGTTTTTTTAAA
AAACTCATGGGAGCAGCATCATGGTACAGTAAAAAAACAAGGGTTTTTATAATAGACAAATATGGTTTTGAACTTGGTTTTGCCACTTAT
TAGATGTGAACCTTTGGGCATGTTAATGTTGTTTACGTTCTTAGATCTTCAGTTTCCTTCTCTATAAACTGGGAGAGATGTCTATTTAAT
CCATAGGGTTGGAATGAAGATGAAGGGAAAATGCCTGTGTAGCCTCACGCCCATAGTACGGAAATCAACTGCTATTTCTCTTTCAGTAAG
AGAAACTGGGTTTGGAATTTATAGTCATTGTTGACTTTAAATCACACATTTTGTGTAATATATTACTTAGGAAAGACCAGAAGTATGTAC
ACCATTTTTTTTTTTTTTTAAATCTCTTGGTGATGTAATTACAGATGATTATTTTCTTTGTACTTTTGGGTACATTCCATTCTTTTTTTC

>In-frame_POLK_ENST00000508526_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1850nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT
CGTCATTTCAAAAGCAAAACTGACTCAAACTCCAAGAAATGTGTAGTTTCATAAATGCCTAAAGAAATTGTATTTACATGATTTTCCACT
CAGCATTCAGTTCTTTTAATGCCATAAATTTCTTCTAGCAGTAGCACTGATTTTCAACTATGATGATGGTGGTGACAGGGAACTCTAACA
GATGAAAGAAGAGTAATACCATGATACTTTTCAACCACTAAAAAGTCAAATATAGTTTTTTTTGCTGAGGGCAAGTTGTATGTGATTTTC
CCATTTCTATCAATCATTTGATGTAATCCATGTAATAAGATAATCTAGGACGGTTTTGTATGTCATGTTTTTTTAAAAAACTCATGGGAG
CAGCATCATGGTACAGTAAAAAAACAAGGGTTTTTATAATAGACAAATATGGTTTTGAACTTGGTTTTGCCACTTATTAGATGTGAACCT
TTGGGCATGTTAATGTTGTTTACGTTCTTAGATCTTCAGTTTCCTTCTCTATAAACTGGGAGAGATGTCTATTTAATCCATAGGGTTGGA
ATGAAGATGAAGGGAAAATGCCTGTGTAGCCTCACGCCCATAGTACGGAAATCAACTGCTATTTCTCTTTCAGTAAGAGAAACTGGGTTT
GGAATTTATAGTCATTGTTGACTTTAAATCACACATTTTGTGTAATATATTACTTAGGAAAGACCAGAAGTATGTACACCATTTTTTTTT
TTTTTTAAATCTCTTGGTGATGTAATTACAGATGATTATTTTCTTTGTACTTTTGGGTACATTCCATTCTTTTTTTCACAAAGAACATGC

>In-frame_POLK_ENST00000504026_chr5_74848416_+_ANKDD1B_ENST00000601380_chr5_74948967_+_1850nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGCTCAATATCAGTAGT
TTGCAGATAGCAACCAGGAACGGCCATGCATCCCTTGTCAACTTTCTTCTCAGTGAGAACGTTGATCTGCACCAGAAAGTGGAACCTAAG
GAGTCCCCTCTTCATTTAGTTGTTATCAACAACCACATCACGGTTGTAAACAGTTTATTAAGTGCACAGCATGATATTGACATCTTAAAT
CAGAAGCAGCAAACCCCTCTGCATGTAGCTGCTGATCGTGGAAATGTGGAACTGGTGGAAACCCTGCTGAAGGCAGGCTGTGACTTGAAG
GCTGTTGACAAGCAAGGAAAGACTGCCCTGGCTGTGGCCTCCAGGAGCAACCATAGCCTTGTCGTGGGCATGCTCATTAAAGCAGAGAGA
TACTACGCCTGGAGAGAGGAGCATCATGAGAGCATCAGGGACCCGTCAACAGGCTTTACTCTGACATTCAAGCAAGATCACAGTCTGGAG
ACCAGACACATTCGCACGCTTCTCTGGGACCTGGCTTACCATCAGCTGAAGGCCAATGAGTGGCAGAGGCTGGCCCGTTCGTGGAACTTT
ACAGATGACCAGATTAGAGCCATTGAGGAGCAGTGGTCGGGAAATGAAAGCTTCCGTGAACATGGCCACAGGGCTCTGCTTATCTGGCTA
CACGGGACCCTGATGACTCAGGGTGACCCGGCCAAGCAACTGTATGAAGAGCTGGTACACGCAGGTTTCCCAAAACTAGCTGAAAAGACT
CGTCATTTCAAAAGCAAAACTGACTCAAACTCCAAGAAATGTGTAGTTTCATAAATGCCTAAAGAAATTGTATTTACATGATTTTCCACT
CAGCATTCAGTTCTTTTAATGCCATAAATTTCTTCTAGCAGTAGCACTGATTTTCAACTATGATGATGGTGGTGACAGGGAACTCTAACA
GATGAAAGAAGAGTAATACCATGATACTTTTCAACCACTAAAAAGTCAAATATAGTTTTTTTTGCTGAGGGCAAGTTGTATGTGATTTTC
CCATTTCTATCAATCATTTGATGTAATCCATGTAATAAGATAATCTAGGACGGTTTTGTATGTCATGTTTTTTTAAAAAACTCATGGGAG
CAGCATCATGGTACAGTAAAAAAACAAGGGTTTTTATAATAGACAAATATGGTTTTGAACTTGGTTTTGCCACTTATTAGATGTGAACCT
TTGGGCATGTTAATGTTGTTTACGTTCTTAGATCTTCAGTTTCCTTCTCTATAAACTGGGAGAGATGTCTATTTAATCCATAGGGTTGGA
ATGAAGATGAAGGGAAAATGCCTGTGTAGCCTCACGCCCATAGTACGGAAATCAACTGCTATTTCTCTTTCAGTAAGAGAAACTGGGTTT
GGAATTTATAGTCATTGTTGACTTTAAATCACACATTTTGTGTAATATATTACTTAGGAAAGACCAGAAGTATGTACACCATTTTTTTTT
TTTTTTAAATCTCTTGGTGATGTAATTACAGATGATTATTTTCTTTGTACTTTTGGGTACATTCCATTCTTTTTTTCACAAAGAACATGC


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FusionGenePPI for POLK_ANKDD1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POLKPCNA, RAD18, XRCC1, POLD1, RPA1, REV1, TRAIP, MSH2, MCM4, XPO7, MCM6, MSH6, KCTD17, PARVG, H3F3A, RAD51, RBM4, STAT6, TIA1, UBE2V2, PIAS1, NOLC1, SRA1, CD2BP2, APOL2, RPAP1, KCTD5, PLXNA3, BHLHE41, ZCCHC6, FIP1L1, CD99L2, KLF16, PCGF5, MAK16, SYNPO2, SBSN, WRN, SPG20, DTD1ANKDD1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POLK_ANKDD1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POLK_ANKDD1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePOLKC0017636Glioblastoma1CTD_human
HgenePOLKC1449861Micronuclei, Chromosome-Defective1CTD_human