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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2794

FusionGeneSummary for ARNTL_TEAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARNTL_TEAD1
Fusion gene ID: 2794
HgeneTgene
Gene symbol

ARNTL

TEAD1

Gene ID

406

7003

Gene namearyl hydrocarbon receptor nuclear translocator likeTEA domain transcription factor 1
SynonymsBMAL1|BMAL1c|JAP3|MOP3|PASD3|TIC|bHLHe5AA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1
Cytomap

11p15.3

11p15.3

Type of geneprotein-codingprotein-coding
Descriptionaryl hydrocarbon receptor nuclear translocator-like protein 1ARNT-like protein 1, brain and musclePAS domain containing 3PAS domain-containing protein 3bHLH-PAS protein JAP3basic helix-loop-helix family member e5basic-helix-loop-helix-PAS orphan MOPtranscriptional enhancer factor TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)protein GT-IICtranscription factor 13transcriptional enhancer factor 1
Modification date2018051920180523
UniProtAcc

O00327

P28347

Ensembl transtripts involved in fusion geneENST00000396441, ENST00000389707, 
ENST00000401424, ENST00000389708, 
ENST00000361003, ENST00000403290, 
ENST00000403510, ENST00000403482, 
ENST00000497429, 		ENST00000361905, 
ENST00000527636, ENST00000527575, 
ENST00000334310, ENST00000361985, 
ENST00000526600, 
Fusion gene scores* DoF score4 X 6 X 5=1205 X 5 X 3=75
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARNTL [Title/Abstract] AND TEAD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARNTL

GO:0032922

circadian regulation of gene expression

24005054

HgeneARNTL

GO:0045893

positive regulation of transcription, DNA-templated

11441146|12738229|23785138

HgeneARNTL

GO:0045944

positive regulation of transcription by RNA polymerase II

20093779

HgeneARNTL

GO:0051775

response to redox state

11441146

TgeneTEAD1

GO:0035329

hippo signaling

18579750|19324877


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A124-01AARNTLchr11

13348014

+TEAD1chr11

12883797

+
TCGARVHNSCTCGA-CV-6961-01AARNTLchr11

13299470

+TEAD1chr11

12883797

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396441ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000396441ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000396441ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000396441ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000396441ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-intronENST00000396441ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-intronENST00000389707ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000401424ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000401424ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000401424ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000401424ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000401424ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-intronENST00000401424ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-intronENST00000389708ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-intronENST00000361003ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-intronENST00000403290ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403510ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403510ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403510ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403510ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403510ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-intronENST00000403510ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-intronENST00000403482ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000361905ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000527636ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000527575ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000334310ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000361985ARNTLchr11

13348014

+TEAD1chr11

12883797

+
intron-intronENST00000497429ENST00000526600ARNTLchr11

13348014

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000396441ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000396441ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000396441ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000396441ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000396441ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000396441ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389707ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000389707ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000401424ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000401424ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000401424ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000401424ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000401424ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000401424ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000389708ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000389708ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000361003ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000361003ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403290ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000403290ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403510ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403510ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403510ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403510ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-3CDSENST00000403510ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
5UTR-intronENST00000403510ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000403482ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-intronENST00000403482ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000361905ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000527636ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000527575ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000334310ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-3CDSENST00000497429ENST00000361985ARNTLchr11

13299470

+TEAD1chr11

12883797

+
intron-intronENST00000497429ENST00000526600ARNTLchr11

13299470

+TEAD1chr11

12883797

+

Top

FusionProtFeatures for ARNTL_TEAD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARNTL

O00327

TEAD1

P28347

Transcription factor which plays a key role in the Hipposignaling pathway, a pathway involved in organ size control andtumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating geneexpression of YAP1 and WWTR1/TAZ, thereby regulating cellproliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and cooperatively to the SPHand GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activatestranscription in vivo in a cell-specific manner. The activationfunction appears to be mediated by a limiting cell-specifictranscriptional intermediary factor (TIF). Involved in cardiacdevelopment. Binds to the M-CAT motif.{ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ARNTL_TEAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARNTL_TEAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARNTLNPAS4, CRY1, CLOCK, EP300, KAT2B, CSNK1E, NPAS2, RXRA, RARA, AHR, HSP90AA1, EPAS1, HIF1A, SIRT1, DYRK1B, UBE3A, CRY2, CSNK2B, DEC1, WDR5, RORC, PPP1CA, RHOU, CREBBP, BCAM, ARNTL2, LRFN4, MAX, RPRD1A, HAUS6, PHLDB3, PTRF, PHF21A, OIP5, CCDC93, CCDC132, HMG20A, RCOR1, GRIPAP1, DZIP3, VPS53, PSMD9, RABGAP1L, GOLGA5, TUFT1, YEATS4, CCHCR1, TFPT, NCKAP5L, PKN3, GIT2, KDM1A, NUF2, THAP11, RABGEF1, JUN, VPS51TEAD1VGLL4, NCOA1, VGLL1, MEF2C, MAX, SRF, SOX2, YAP1, HLA-DMB, INSR, GCAT, UBTD1, ZDHHC17, TEAD4, RAD51, WWTR1, FOXK2, SKI, TEAD2, TRIM25, PFKM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARNTL_TEAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARNTL_TEAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARNTLC0005586Bipolar Disorder5PSYGENET
HgeneARNTLC0011570Mental Depression3PSYGENET
HgeneARNTLC0011581Depressive disorder3PSYGENET
HgeneARNTLC0525045Mood Disorders2PSYGENET
HgeneARNTLC0021361Female infertility1CTD_human
HgeneARNTLC0023473Myeloid Leukemia, Chronic1CTD_human
HgeneARNTLC0085159Seasonal Affective Disorder1PSYGENET
HgeneARNTLC0151744Myocardial Ischemia1CTD_human
TgeneTEAD1C1862382SVEINSSON CHORIORETINAL ATROPHY1CTD_human;ORPHANET;UNIPROT