FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27934

FusionGeneSummary for POLG_CGNL1

check button Fusion gene summary
Fusion gene informationFusion gene name: POLG_CGNL1
Fusion gene ID: 27934
HgeneTgene
Gene symbol

POLG

CGNL1

Gene ID

5428

84952

Gene nameDNA polymerase gamma, catalytic subunitcingulin like 1
SynonymsMDP1|MIRAS|MTDPS4A|MTDPS4B|PEO|POLG1|POLGA|SANDO|SCAEJACOP|PCING
Cytomap

15q26.1

15q21.3

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase subunit gamma-1PolG-alphamitochondrial DNA polymerase catalytic subunitpolymerase (DNA directed), gammapolymerase (DNA) gamma, catalytic subunittruncated mitochondrial DNA polymerase gamma catalytic subunitcingulin-like protein 1junction-associated coiled-coil proteinparacingulin
Modification date2018052320180519
UniProtAcc

P54098

Q0VF96

Ensembl transtripts involved in fusion geneENST00000268124, ENST00000442287, 
ENST00000525806, 
ENST00000281282, 
ENST00000557813, 
Fusion gene scores* DoF score2 X 3 X 2=122 X 2 X 2=8
# samples 32
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: POLG [Title/Abstract] AND CGNL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLG

GO:0006287

base-excision repair, gap-filling

15177179


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-AAVW-01APOLGchr15

89866635

-CGNL1chr15

57808978

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000268124ENST00000281282POLGchr15

89866635

-CGNL1chr15

57808978

+
5CDS-intronENST00000268124ENST00000557813POLGchr15

89866635

-CGNL1chr15

57808978

+
In-frameENST00000442287ENST00000281282POLGchr15

89866635

-CGNL1chr15

57808978

+
5CDS-intronENST00000442287ENST00000557813POLGchr15

89866635

-CGNL1chr15

57808978

+
intron-3CDSENST00000525806ENST00000281282POLGchr15

89866635

-CGNL1chr15

57808978

+
intron-intronENST00000525806ENST00000557813POLGchr15

89866635

-CGNL1chr15

57808978

+

Top

FusionProtFeatures for POLG_CGNL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLG

P54098

CGNL1

Q0VF96

Involved in the replication of mitochondrial DNA.Associates with mitochondrial DNA. May be involved in anchoring the apical junctionalcomplex, especially tight junctions, to actin-based cytoskeletons.{ECO:0000269|PubMed:22891260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLGchr15:89866635chr15:57808978ENST00000268124-132343_607551240Compositional biasNote=Poly-Gln
HgenePOLGchr15:89866635chr15:57808978ENST00000268124-1323535_5387551240Compositional biasNote=Poly-Glu
HgenePOLGchr15:89866635chr15:57808978ENST00000442287-132343_607551240Compositional biasNote=Poly-Gln
HgenePOLGchr15:89866635chr15:57808978ENST00000442287-1323535_5387551240Compositional biasNote=Poly-Glu
TgeneCGNL1chr15:89866635chr15:57808978ENST00000281282+7191268_12758011303Compositional biasNote=Poly-Asp
TgeneCGNL1chr15:89866635chr15:57808978ENST00000281282+7191263_13028011303RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCGNL1chr15:89866635chr15:57808978ENST00000281282+719604_12588011303Coiled coilOntology_term=ECO:0000255
TgeneCGNL1chr15:89866635chr15:57808978ENST00000281282+719296_3008011303Compositional biasNote=Poly-Ser
TgeneCGNL1chr15:89866635chr15:57808978ENST00000281282+71937_518011303MotifZIM
TgeneCGNL1chr15:89866635chr15:57808978ENST00000281282+7191_5548011303RegionNote=Head


Top

FusionGeneSequence for POLG_CGNL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_POLG_ENST00000268124_chr15_89866635_-_CGNL1_ENST00000281282_chr15_57808978_+_1257aa
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQ
GGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGP
EGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHN
VSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVH
RLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQG
TYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQ
QDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDN
LAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALT
ARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK
GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHL
GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQ
LLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN
KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE

>In-frame_POLG_ENST00000442287_chr15_89866635_-_CGNL1_ENST00000281282_chr15_57808978_+_1257aa
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQ
GGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGP
EGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHN
VSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVH
RLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQG
TYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQ
QDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDN
LAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALT
ARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK
GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHL
GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQ
LLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN
KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_POLG_ENST00000268124_chr15_89866635_-_CGNL1_ENST00000281282_chr15_57808978_+_3771nt
ATGAGCCGCCTGCTCTGGAGGAAGGTGGCCGGCGCCACCGTCGGGCCAGGGCCGGTTCCAGCTCCGGGGCGCTGGGTCTCCAGCTCCGTC
CCCGCGTCCGACCCCAGCGACGGGCAGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCCTCAGCAGCCGCAA
GTGCTATCCTCGGAGGGCGGGCAGCTGCGGCACAACCCATTGGACATCCAGATGCTCTCGAGAGGGCTGCACGAGCAAATCTTCGGGCAA
GGAGGGGAGATGCCTGGCGAGGCCGCGGTGCGCCGCAGCGTCGAGCACCTGCAGAAGCACGGGCTCTGGGGGCAGCCAGCCGTGCCCTTG
CCCGACGTGGAGCTGCGCCTGCCGCCCCTCTACGGGGACAACCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTAC
CTGGAGGCGGCCAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCC
GAGGGGGAGGCCGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACA
TTGGCGGTGGCCATATCCCCCTCGGCCTGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCG
CCGGCTGACCTCATCCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAAT
GTTTCCTTTGACCGAGCTCATATCAGGGAGCAGTACCTGATCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCC
ATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAG
AAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCAC
AGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAG
GACCTGATGCAGTACTGTGCCCAGGACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGGTGTCCCCAC
CCAGTGACTCTGGCCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGC
ACTTATGAGGAGCTCCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGTACAAA
GAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCC
AGCAAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAA
CAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCT
GGATGGTACCGGAAGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCT
AAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAAC
CTGGCCAAGCTGCCGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGAGCCATCGAGTCCCTGTACAGGAAGCACTGT
CTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACG
GTAGAAGAACTGGATTACTTAGAAGTGGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGACT
GCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTC
AAGCTGCCTCACAAGAATGTCGAGGTCTTGGCGAGCAGGAGCAACACTTCAGAGCAAGACCAGGCGGGGACTGAAATGCGCGTGAAGCTT
CTGCAGGAGGAGAATGAGAAGCTGCAGGGAAGAAGCGAAGAGCTGGAGCGGAGAGTTGCTCAGCTTCAAAGGCAGATCGAGGACCTGAAA
GGCGATGAAGCCAAGGCGAAGGAAACGCTGAAGAAGTACGAGGGAGAAATACGACAGTTAGAGGAGGCCCTTGTGCACGCCAGAAAGGAA
GAAAAAGAAGCTGTGTCAGCCAGAAGGGCCCTGGAGAATGAACTGGAGGCTGCTCAGGGAAATCTGAGTCAGACTACCCAGGAGCAGAAG
CAGTTGTCTGAGAAGCTCAAAGAGGAGAGTGAGCAGAAGGAGCAGCTAAGAAGGTTGAAGAACGAGATGGAGAATGAGCGGTGGCACCTG
GGCAAAACCATTGAGAAACTGCAGAAGGAGATGGCAGACATTGTTGAGGCCTCCCGTACCTCAACCCTGGAGCTCCAGAACCAGCTGGAT
GAGTATAAGGAGAAAAACCGCAGGGAGCTCGCAGAAATGCAAAGACAGTTGAAGGAGAAAACGCTGGAGGCAGAAAAGTCCCGACTGACA
GCCATGAAAATGCAGGATGAGATGCGTCTGATGGAGGAAGAGTTACGGGACTACCAGAGAGCTCAGGATGAAGCACTCACAAAAAGGCAG
CTTCTGGAGCAGACGCTGAAGGACCTGGAGTATGAGCTGGAAGCCAAGAGTCACCTCAAAGATGACCGCAGCAGGCTGGTCAAGCAGATG
GAGGACAAGGTGTCTCAACTGGAGATGGAACTGGAAGAAGAGAGAAACAACTCAGATTTGCTGTCTGAGAGGATCAGTAGGAGCAGGGAA
CAGATGGAGCAGTTGAGGAATGAGCTACTTCAGGAGAGAGCTGCGAGACAAGACTTGGAGTGCGACAAGATTTCCCTGGAGAGGCAGAAC
AAGGACTTAAAGAGCCGGATTATCCACCTGGAAGGTTCCTACAGGTCCAGCAAAGAGGGGCTGGTTGTGCAGATGGAGGCCAGGATCGCG
GAGCTGGAGGACCGCCTGGAGAGTGAGGAGAGGGATCGGGCCAATCTTCAGCTCAGCAACCGGCGGCTGGAGCGGAAAGTGAAGGAGCTG
GTGATGCAGGTGGATGATGAGCACCTGTCATTGACTGATCAGAAGGACCAGCTGAGCTTGCGTTTGAAAGCCATGAAGCGGCAGGTGGAG
GAGGCTGAGGAGGAAATCGACAGACTGGAAAGTTCTAAAAAGAAGCTGCAGAGGGAGCTGGAGGAGCAGATGGACATGAATGAGCATCTG
CAGGGGCAGCTCAACTCCATGAAGAAGGACTTAAGACTGAAGAAGCTGCCGAGTAAAGTGCTGGATGACATGGATGACGACGATGACCTC

>In-frame_POLG_ENST00000442287_chr15_89866635_-_CGNL1_ENST00000281282_chr15_57808978_+_3771nt
ATGAGCCGCCTGCTCTGGAGGAAGGTGGCCGGCGCCACCGTCGGGCCAGGGCCGGTTCCAGCTCCGGGGCGCTGGGTCTCCAGCTCCGTC
CCCGCGTCCGACCCCAGCGACGGGCAGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCCTCAGCAGCCGCAA
GTGCTATCCTCGGAGGGCGGGCAGCTGCGGCACAACCCATTGGACATCCAGATGCTCTCGAGAGGGCTGCACGAGCAAATCTTCGGGCAA
GGAGGGGAGATGCCTGGCGAGGCCGCGGTGCGCCGCAGCGTCGAGCACCTGCAGAAGCACGGGCTCTGGGGGCAGCCAGCCGTGCCCTTG
CCCGACGTGGAGCTGCGCCTGCCGCCCCTCTACGGGGACAACCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTAC
CTGGAGGCGGCCAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCC
GAGGGGGAGGCCGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACA
TTGGCGGTGGCCATATCCCCCTCGGCCTGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCG
CCGGCTGACCTCATCCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAAT
GTTTCCTTTGACCGAGCTCATATCAGGGAGCAGTACCTGATCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCC
ATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAG
AAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCAC
AGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAG
GACCTGATGCAGTACTGTGCCCAGGACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGGTGTCCCCAC
CCAGTGACTCTGGCCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGC
ACTTATGAGGAGCTCCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGTACAAA
GAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCC
AGCAAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAA
CAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCT
GGATGGTACCGGAAGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCT
AAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAAC
CTGGCCAAGCTGCCGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGAGCCATCGAGTCCCTGTACAGGAAGCACTGT
CTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACG
GTAGAAGAACTGGATTACTTAGAAGTGGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGACT
GCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTC
AAGCTGCCTCACAAGAATGTCGAGGTCTTGGCGAGCAGGAGCAACACTTCAGAGCAAGACCAGGCGGGGACTGAAATGCGCGTGAAGCTT
CTGCAGGAGGAGAATGAGAAGCTGCAGGGAAGAAGCGAAGAGCTGGAGCGGAGAGTTGCTCAGCTTCAAAGGCAGATCGAGGACCTGAAA
GGCGATGAAGCCAAGGCGAAGGAAACGCTGAAGAAGTACGAGGGAGAAATACGACAGTTAGAGGAGGCCCTTGTGCACGCCAGAAAGGAA
GAAAAAGAAGCTGTGTCAGCCAGAAGGGCCCTGGAGAATGAACTGGAGGCTGCTCAGGGAAATCTGAGTCAGACTACCCAGGAGCAGAAG
CAGTTGTCTGAGAAGCTCAAAGAGGAGAGTGAGCAGAAGGAGCAGCTAAGAAGGTTGAAGAACGAGATGGAGAATGAGCGGTGGCACCTG
GGCAAAACCATTGAGAAACTGCAGAAGGAGATGGCAGACATTGTTGAGGCCTCCCGTACCTCAACCCTGGAGCTCCAGAACCAGCTGGAT
GAGTATAAGGAGAAAAACCGCAGGGAGCTCGCAGAAATGCAAAGACAGTTGAAGGAGAAAACGCTGGAGGCAGAAAAGTCCCGACTGACA
GCCATGAAAATGCAGGATGAGATGCGTCTGATGGAGGAAGAGTTACGGGACTACCAGAGAGCTCAGGATGAAGCACTCACAAAAAGGCAG
CTTCTGGAGCAGACGCTGAAGGACCTGGAGTATGAGCTGGAAGCCAAGAGTCACCTCAAAGATGACCGCAGCAGGCTGGTCAAGCAGATG
GAGGACAAGGTGTCTCAACTGGAGATGGAACTGGAAGAAGAGAGAAACAACTCAGATTTGCTGTCTGAGAGGATCAGTAGGAGCAGGGAA
CAGATGGAGCAGTTGAGGAATGAGCTACTTCAGGAGAGAGCTGCGAGACAAGACTTGGAGTGCGACAAGATTTCCCTGGAGAGGCAGAAC
AAGGACTTAAAGAGCCGGATTATCCACCTGGAAGGTTCCTACAGGTCCAGCAAAGAGGGGCTGGTTGTGCAGATGGAGGCCAGGATCGCG
GAGCTGGAGGACCGCCTGGAGAGTGAGGAGAGGGATCGGGCCAATCTTCAGCTCAGCAACCGGCGGCTGGAGCGGAAAGTGAAGGAGCTG
GTGATGCAGGTGGATGATGAGCACCTGTCATTGACTGATCAGAAGGACCAGCTGAGCTTGCGTTTGAAAGCCATGAAGCGGCAGGTGGAG
GAGGCTGAGGAGGAAATCGACAGACTGGAAAGTTCTAAAAAGAAGCTGCAGAGGGAGCTGGAGGAGCAGATGGACATGAATGAGCATCTG
CAGGGGCAGCTCAACTCCATGAAGAAGGACTTAAGACTGAAGAAGCTGCCGAGTAAAGTGCTGGATGACATGGATGACGACGATGACCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_POLG_ENST00000268124_chr15_89866635_-_CGNL1_ENST00000281282_chr15_57808978_+_7342nt
GTAGCCGCGGGACCTAGCTGGGTGCAGACGGGAAGTTGCGGCTGCCAGCGAAGCGGACCGGCCGGGTGGAGGCCACACGCTACCCCGAGG
CTGCGTAGGCCGCGCGAAGGGGGACGCCGTGCCGTGGGCCTGGGGTCGGGGGAGCAGCAGACCGGGAAGCACCGTGAGGACCGAGGATTT
GGGGTGGAAGGCAGGCATGGTCAAACCCATTTCACTGACAGGAGAGCAGAGACAGGACGTGTCTCTCTCCACGTCTTCCAGCCAGTAAAA
GAAGCCAAGCTGGAGCCCAAAGCCAGGTGTTCTGACTCCCAGCGTGGGGGTCCCTGCACCAACCATGAGCCGCCTGCTCTGGAGGAAGGT
GGCCGGCGCCACCGTCGGGCCAGGGCCGGTTCCAGCTCCGGGGCGCTGGGTCTCCAGCTCCGTCCCCGCGTCCGACCCCAGCGACGGGCA
GCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCCTCAGCAGCCGCAAGTGCTATCCTCGGAGGGCGGGCAGCT
GCGGCACAACCCATTGGACATCCAGATGCTCTCGAGAGGGCTGCACGAGCAAATCTTCGGGCAAGGAGGGGAGATGCCTGGCGAGGCCGC
GGTGCGCCGCAGCGTCGAGCACCTGCAGAAGCACGGGCTCTGGGGGCAGCCAGCCGTGCCCTTGCCCGACGTGGAGCTGCGCCTGCCGCC
CCTCTACGGGGACAACCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTGCA
GGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCCAT
CCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTGGCCATATCCCCCTCGGC
CTGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTCATCCCCCTGGAGGT
CCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCGAGCTCATATCAG
GGAGCAGTACCTGATCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGCTTCCAGCG
CAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCCAGAAGAGG
CCCAGCGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTT
AGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAGGACCTGATGCAGTACTGTGCCCAGGA
CGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGGTGTCCCCACCCAGTGACTCTGGCCGGCATGCTGGA
GATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCTCCAGCGGGAGAT
GAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGTACAAAGAAGACCCCTGGCTCTGGGACCTGGA
GTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGG
GGCCCCTGGTGATCCCATGGATCAGGAAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAACAAGATGTCATGGCCCGCGCCTGCTT
GCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCTGGATGGTACCGGAAGCTCTGCCCCCG
GCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCTAAACTCATGGCACTTACCTGGGATGG
CTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGACAGGTACCAC
CCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGAGCCATCGAGTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAAGCAGCAGCTGAT
GCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACGGTAGAAGAACTGGATTACTTAGAAGT
GGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGACTGCCCGTGGTGGCCCCAAGGACACCCA
GCCCAGCTATCACCATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGAATGTCGAGGT
CTTGGCGAGCAGGAGCAACACTTCAGAGCAAGACCAGGCGGGGACTGAAATGCGCGTGAAGCTTCTGCAGGAGGAGAATGAGAAGCTGCA
GGGAAGAAGCGAAGAGCTGGAGCGGAGAGTTGCTCAGCTTCAAAGGCAGATCGAGGACCTGAAAGGCGATGAAGCCAAGGCGAAGGAAAC
GCTGAAGAAGTACGAGGGAGAAATACGACAGTTAGAGGAGGCCCTTGTGCACGCCAGAAAGGAAGAAAAAGAAGCTGTGTCAGCCAGAAG
GGCCCTGGAGAATGAACTGGAGGCTGCTCAGGGAAATCTGAGTCAGACTACCCAGGAGCAGAAGCAGTTGTCTGAGAAGCTCAAAGAGGA
GAGTGAGCAGAAGGAGCAGCTAAGAAGGTTGAAGAACGAGATGGAGAATGAGCGGTGGCACCTGGGCAAAACCATTGAGAAACTGCAGAA
GGAGATGGCAGACATTGTTGAGGCCTCCCGTACCTCAACCCTGGAGCTCCAGAACCAGCTGGATGAGTATAAGGAGAAAAACCGCAGGGA
GCTCGCAGAAATGCAAAGACAGTTGAAGGAGAAAACGCTGGAGGCAGAAAAGTCCCGACTGACAGCCATGAAAATGCAGGATGAGATGCG
TCTGATGGAGGAAGAGTTACGGGACTACCAGAGAGCTCAGGATGAAGCACTCACAAAAAGGCAGCTTCTGGAGCAGACGCTGAAGGACCT
GGAGTATGAGCTGGAAGCCAAGAGTCACCTCAAAGATGACCGCAGCAGGCTGGTCAAGCAGATGGAGGACAAGGTGTCTCAACTGGAGAT
GGAACTGGAAGAAGAGAGAAACAACTCAGATTTGCTGTCTGAGAGGATCAGTAGGAGCAGGGAACAGATGGAGCAGTTGAGGAATGAGCT
ACTTCAGGAGAGAGCTGCGAGACAAGACTTGGAGTGCGACAAGATTTCCCTGGAGAGGCAGAACAAGGACTTAAAGAGCCGGATTATCCA
CCTGGAAGGTTCCTACAGGTCCAGCAAAGAGGGGCTGGTTGTGCAGATGGAGGCCAGGATCGCGGAGCTGGAGGACCGCCTGGAGAGTGA
GGAGAGGGATCGGGCCAATCTTCAGCTCAGCAACCGGCGGCTGGAGCGGAAAGTGAAGGAGCTGGTGATGCAGGTGGATGATGAGCACCT
GTCATTGACTGATCAGAAGGACCAGCTGAGCTTGCGTTTGAAAGCCATGAAGCGGCAGGTGGAGGAGGCTGAGGAGGAAATCGACAGACT
GGAAAGTTCTAAAAAGAAGCTGCAGAGGGAGCTGGAGGAGCAGATGGACATGAATGAGCATCTGCAGGGGCAGCTCAACTCCATGAAGAA
GGACTTAAGACTGAAGAAGCTGCCGAGTAAAGTGCTGGATGACATGGATGACGACGATGACCTCAGCACGGATGGGGGAAGCCTCTATGA
GGCGCCTGTGAGCTACACATTCTCCAAGGACAGCACCGTCGCCAGCCAGATCTGAGTGCTCTCCCGGGCTGTGGAAGTACCTGTCATTCC
TGCAGGAGCTGCAGCCACCCAAAGTGGGAGGCAGGGAGGGGAGCATCTGTCTGCCACTGAGACCAATCACAGCCTCTTTGCACAGCATGC
CAGCTCCTCAGTGTTACATTCCTCGCCAGGGTCTCTCAGTGGGTCTTCGACAGAGAGCTTTTGCAGTTTAAAATGTTGGGATGCCTGAGG
ACCAGGAGCCACCACCCACTGGGGTGTTGTGAGAGATACACTTTGGTAGGCTGAGGCCCCTGTTCCACAGCCACTATTTGCATTGCTGTC
CCTGCCCCCTCATCACTCCCCCTGCCAAGACAAAGGGTCCAGAAGGCTAGGACTTACTTAATAGCACTGTGCAGGGAGGAAACCATGTAT
AGCTTGTACATATTTTAAACCAGACCTTCTCACGAACTGCTGCTGTTGGGTTTGGAATGTGATGGAGGCTTGGTAGGGTGGCTGGTTTGT
AAAGTTCATGCATCTATATTGAGTATTCTTTTTTTTTTTTTTTGAGATGGAGTTTCATTCTTGTTGCCGAGGCTGGAGTGCAATGGCGCA
ACCTTGGCTCACTGCAACCTCTGCCTCCCTGGTTCAAGTGATTCTCCTGCCTCATCCTCCCAAGAAGCTGAGATTACAGATGACCACCAC
CACTCCTGGCTAATTTTTTGTATTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCAC
CTGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACCACGCCCAGCCATTGAGTATTCTTTTTTAAAATATGAAGCTATTAG
ATTTTAAGTGTTGAGGAGCAGAGGTGAGAAGAGAGAGAGAGAGAGAAAGTCAAATAAAGTCAAAGACCAGTTTGGAAACCAAAGTTGGAA
AAGAAGAATTGTAGTGGTCATGGACAGCTAAGACTGAGCATAGCAGTTCACATGGTCTGGGTAAACAAGTCACTGGCACAGGGGAAAGCC
AGAAGGTTGCTTGTGTCTGTGACTGCAGCTATGGCCTTGTTTGCTTAGTTTATCTGGAATTCTGTTATAATTTCTGAACTGTTCTGAGAC
CTGTTCCCAGTCACTGATTGCAATTTCTTTTACACAGGTTGGGTAGGGAGAGTTGTAGGTAAGGCCTTAAACAAATGAGGCCGTTTCTGG
AAGGATAGGGCTGTGTGGTCATGTCCCACAGCAAGCTTTTGGGATCGGGGGAATAAGAGGGTATGGGGGAAAGGTTCATAGACTTAGGTG
TGAGAATGAGGTGGGAGGTGTCTGGTAAGGTCATGGGGGAAGGGAGATGAGAGAGGAGATAGGCAGATGTGGGTATGGGGCCCAGTGTGA
GAAGGAAGACAGAGAAGTTCTTGAAAGCTGGGGGATGTGTGGGCAAGAGGTGGATTGAGCAGGATCTCAGGGTTATGTCGAGGAAGGGAA
GAAAGAAACAGAAGTCAGGCAGAGGCGTGTCTGTGCAAACTGGAGGACTCCTTCCAACTTCCTGGAACAAAGCGACATCGCCAGCAGCAG
GCTGGCAGGGAGTGGTTGAGGTCTGGGGGCCAGGCCACATGGCTGGAGAGGAATTTCAGGGAGCATAGCATCGGGAGGATGCTACATATC
CAGGGACTCCCTCCTGGCCTTCCTGTGTCACTTCACAATGTGACAGTCCCCAGGCATGCCCACAGGCCAGGCCCAGTCACAGCTGGGCTT
CCACAGGTCAGAATATGGGACAGGACATGGTCAGGGAGAGGACCCTGTGAGTTGGTGACATATATGTGGCAGAGATGGTAGTGTTCAGCT
GCTTCAGCAGTGTCCCCAACCATCCCAATAGGGTGGGGGCCTGTGGGCCAGAGGACTCCATGACAGTAGCCATGGAGTCCCACCTGTGCC
AGGTCAGAGCCCACCCGGCAGGTTTCAGAGTGGTCAGCCCAGTTTAAGGGTGGGAGTCTGGAGCCAGACAGCCAAGCCCCTTCCACATCT
ACAGGGTCACTGTCATCCTCACCACAGCCAGGGGTGATTCTCACCTCTGCCTGCTTATGTGGGGTGTGGCCGATTCCTCCCTTTAGTCAT
TCATTCATTTAGCACATATTTATTGGGCATCGGTGATGTGTCAGGCACAGTCCTTGGCACACAGAATACAGCAGTGAATTAAACAGGCAA
AAATTCCTCCCCTCCTGGAGCTCAGTGTCAGGAAAGGGGGTGATAAATGACAATCAAATCGACATGGAGGTTGAGCACCTCTGTACTCAG
CCCTCTGTCTGTCCTTCTGAGGACGCAACAAGCCTGGTTCCCTAGAGCTCACTTTGACCCTCAATATGTTCATAATTTCCCTGCTGCTTC
TCCCATCGTTAGACATCTGCCAGTAAGCCTGCTGAGAGAAGCCTCAGCCCACTCATACCTAGAGACGCTGCTGGGGAAGGTCAGCACACC
CAAGAACTTTGGGAGTGTGTGTCTGTTTTGGTTTGTGAGAAAGTAGCTGCCCCTCATTCTGGCCAGTTCTTTCCAGTAGCCATGGGGCTG
GCTACAAGAAGCAAAACTGCCCATGCAAAGAGAACACAGGTCACTTTTCAAAACACTTGCATCATTACCCTAAAAATAGGCTGTTATGCG
TTTTGACAATTGCGCTATCCTACACTCTGAGGGAGTTGGCAACGCATGCGGTATAGTGGAGTGGGAAGAGTTGAGACTGAAAGTTAAGAG
AAGGGTTTTCAAGTCCCGGCTCATCTCACCCCAGTGACTTTGACAGTGTGCTCACTCTCAGAGCCATGGATTACCTGGAACAAAGTGCAG
ATTAGTGCCCACGGTCCTTTCCAGGTATAACATGCTATCGTTCTTTAATTTTATTATATATACATACTTTTCTTCTGTTTTTTGCTTTAA
GAACTAACCCCGATCAAGAGTATTTTCTTTAGCTAGCTTAAAAAGAAAACATATATTTTATGTAAAAACACATACATGGCCAAATGCAAT
ACTGAAGAGACAATCATCCTGTATCTTTTATGGTTTTTCCTGCTTCTGAGTGTCGTTCTACAATGCCCGTTGACTTATTCCATTGCGTCT
CTGCTTTAGGGTATGGTTTGGTCGCTTTGGTTGTCATGAGAAAGAGACATTCTCCTTGCAGCTACCTCCATGTGAGTGAATTCCTGGATA

>In-frame_POLG_ENST00000442287_chr15_89866635_-_CGNL1_ENST00000281282_chr15_57808978_+_7344nt
CGCTTGCCTCTCGGGTAGCCGCGGGACCTAGCTGGGTGCAGACGGGAAGTTGCGGCTGCCAGCGAAGCGGACCGGCCGGGTGGAGGCCAC
ACGCTACCCCGAGGCTGCGTAGGCCGCGCGAAGGGGGACGCCGTGCCGTGGGCCTGGGGTCGGGGGAGCAGCAGACCGGGAAGCACCGAT
TTGGGGTGGAAGGCAGGCATGGTCAAACCCATTTCACTGACAGGAGAGCAGAGACAGGACGTGTCTCTCTCCACGTCTTCCAGCCAGTAA
AAGAAGCCAAGCTGGAGCCCAAAGCCAGGTGTTCTGACTCCCAGCGTGGGGGTCCCTGCACCAACCATGAGCCGCCTGCTCTGGAGGAAG
GTGGCCGGCGCCACCGTCGGGCCAGGGCCGGTTCCAGCTCCGGGGCGCTGGGTCTCCAGCTCCGTCCCCGCGTCCGACCCCAGCGACGGG
CAGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCCTCAGCAGCCGCAAGTGCTATCCTCGGAGGGCGGGCAG
CTGCGGCACAACCCATTGGACATCCAGATGCTCTCGAGAGGGCTGCACGAGCAAATCTTCGGGCAAGGAGGGGAGATGCCTGGCGAGGCC
GCGGTGCGCCGCAGCGTCGAGCACCTGCAGAAGCACGGGCTCTGGGGGCAGCCAGCCGTGCCCTTGCCCGACGTGGAGCTGCGCCTGCCG
CCCCTCTACGGGGACAACCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTG
CAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCC
ATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTGGCCATATCCCCCTCG
GCCTGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTCATCCCCCTGGAG
GTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCGAGCTCATATC
AGGGAGCAGTACCTGATCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGCTTCCAG
CGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCCAGAAGA
GGCCCAGCGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCC
TTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAGGACCTGATGCAGTACTGTGCCCAG
GACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGGTGTCCCCACCCAGTGACTCTGGCCGGCATGCTG
GAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCTCCAGCGGGAG
ATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGTACAAAGAAGACCCCTGGCTCTGGGACCTG
GAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCT
GGGGCCCCTGGTGATCCCATGGATCAGGAAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAACAAGATGTCATGGCCCGCGCCTGC
TTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCTGGATGGTACCGGAAGCTCTGCCCC
CGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCTAAACTCATGGCACTTACCTGGGAT
GGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGACAGGTACC
ACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGAGCCATCGAGTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAAGCAGCAGCTG
ATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACGGTAGAAGAACTGGATTACTTAGAA
GTGGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGACTGCCCGTGGTGGCCCCAAGGACACC
CAGCCCAGCTATCACCATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGAATGTCGAG
GTCTTGGCGAGCAGGAGCAACACTTCAGAGCAAGACCAGGCGGGGACTGAAATGCGCGTGAAGCTTCTGCAGGAGGAGAATGAGAAGCTG
CAGGGAAGAAGCGAAGAGCTGGAGCGGAGAGTTGCTCAGCTTCAAAGGCAGATCGAGGACCTGAAAGGCGATGAAGCCAAGGCGAAGGAA
ACGCTGAAGAAGTACGAGGGAGAAATACGACAGTTAGAGGAGGCCCTTGTGCACGCCAGAAAGGAAGAAAAAGAAGCTGTGTCAGCCAGA
AGGGCCCTGGAGAATGAACTGGAGGCTGCTCAGGGAAATCTGAGTCAGACTACCCAGGAGCAGAAGCAGTTGTCTGAGAAGCTCAAAGAG
GAGAGTGAGCAGAAGGAGCAGCTAAGAAGGTTGAAGAACGAGATGGAGAATGAGCGGTGGCACCTGGGCAAAACCATTGAGAAACTGCAG
AAGGAGATGGCAGACATTGTTGAGGCCTCCCGTACCTCAACCCTGGAGCTCCAGAACCAGCTGGATGAGTATAAGGAGAAAAACCGCAGG
GAGCTCGCAGAAATGCAAAGACAGTTGAAGGAGAAAACGCTGGAGGCAGAAAAGTCCCGACTGACAGCCATGAAAATGCAGGATGAGATG
CGTCTGATGGAGGAAGAGTTACGGGACTACCAGAGAGCTCAGGATGAAGCACTCACAAAAAGGCAGCTTCTGGAGCAGACGCTGAAGGAC
CTGGAGTATGAGCTGGAAGCCAAGAGTCACCTCAAAGATGACCGCAGCAGGCTGGTCAAGCAGATGGAGGACAAGGTGTCTCAACTGGAG
ATGGAACTGGAAGAAGAGAGAAACAACTCAGATTTGCTGTCTGAGAGGATCAGTAGGAGCAGGGAACAGATGGAGCAGTTGAGGAATGAG
CTACTTCAGGAGAGAGCTGCGAGACAAGACTTGGAGTGCGACAAGATTTCCCTGGAGAGGCAGAACAAGGACTTAAAGAGCCGGATTATC
CACCTGGAAGGTTCCTACAGGTCCAGCAAAGAGGGGCTGGTTGTGCAGATGGAGGCCAGGATCGCGGAGCTGGAGGACCGCCTGGAGAGT
GAGGAGAGGGATCGGGCCAATCTTCAGCTCAGCAACCGGCGGCTGGAGCGGAAAGTGAAGGAGCTGGTGATGCAGGTGGATGATGAGCAC
CTGTCATTGACTGATCAGAAGGACCAGCTGAGCTTGCGTTTGAAAGCCATGAAGCGGCAGGTGGAGGAGGCTGAGGAGGAAATCGACAGA
CTGGAAAGTTCTAAAAAGAAGCTGCAGAGGGAGCTGGAGGAGCAGATGGACATGAATGAGCATCTGCAGGGGCAGCTCAACTCCATGAAG
AAGGACTTAAGACTGAAGAAGCTGCCGAGTAAAGTGCTGGATGACATGGATGACGACGATGACCTCAGCACGGATGGGGGAAGCCTCTAT
GAGGCGCCTGTGAGCTACACATTCTCCAAGGACAGCACCGTCGCCAGCCAGATCTGAGTGCTCTCCCGGGCTGTGGAAGTACCTGTCATT
CCTGCAGGAGCTGCAGCCACCCAAAGTGGGAGGCAGGGAGGGGAGCATCTGTCTGCCACTGAGACCAATCACAGCCTCTTTGCACAGCAT
GCCAGCTCCTCAGTGTTACATTCCTCGCCAGGGTCTCTCAGTGGGTCTTCGACAGAGAGCTTTTGCAGTTTAAAATGTTGGGATGCCTGA
GGACCAGGAGCCACCACCCACTGGGGTGTTGTGAGAGATACACTTTGGTAGGCTGAGGCCCCTGTTCCACAGCCACTATTTGCATTGCTG
TCCCTGCCCCCTCATCACTCCCCCTGCCAAGACAAAGGGTCCAGAAGGCTAGGACTTACTTAATAGCACTGTGCAGGGAGGAAACCATGT
ATAGCTTGTACATATTTTAAACCAGACCTTCTCACGAACTGCTGCTGTTGGGTTTGGAATGTGATGGAGGCTTGGTAGGGTGGCTGGTTT
GTAAAGTTCATGCATCTATATTGAGTATTCTTTTTTTTTTTTTTTGAGATGGAGTTTCATTCTTGTTGCCGAGGCTGGAGTGCAATGGCG
CAACCTTGGCTCACTGCAACCTCTGCCTCCCTGGTTCAAGTGATTCTCCTGCCTCATCCTCCCAAGAAGCTGAGATTACAGATGACCACC
ACCACTCCTGGCTAATTTTTTGTATTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCC
ACCTGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACCACGCCCAGCCATTGAGTATTCTTTTTTAAAATATGAAGCTATT
AGATTTTAAGTGTTGAGGAGCAGAGGTGAGAAGAGAGAGAGAGAGAGAAAGTCAAATAAAGTCAAAGACCAGTTTGGAAACCAAAGTTGG
AAAAGAAGAATTGTAGTGGTCATGGACAGCTAAGACTGAGCATAGCAGTTCACATGGTCTGGGTAAACAAGTCACTGGCACAGGGGAAAG
CCAGAAGGTTGCTTGTGTCTGTGACTGCAGCTATGGCCTTGTTTGCTTAGTTTATCTGGAATTCTGTTATAATTTCTGAACTGTTCTGAG
ACCTGTTCCCAGTCACTGATTGCAATTTCTTTTACACAGGTTGGGTAGGGAGAGTTGTAGGTAAGGCCTTAAACAAATGAGGCCGTTTCT
GGAAGGATAGGGCTGTGTGGTCATGTCCCACAGCAAGCTTTTGGGATCGGGGGAATAAGAGGGTATGGGGGAAAGGTTCATAGACTTAGG
TGTGAGAATGAGGTGGGAGGTGTCTGGTAAGGTCATGGGGGAAGGGAGATGAGAGAGGAGATAGGCAGATGTGGGTATGGGGCCCAGTGT
GAGAAGGAAGACAGAGAAGTTCTTGAAAGCTGGGGGATGTGTGGGCAAGAGGTGGATTGAGCAGGATCTCAGGGTTATGTCGAGGAAGGG
AAGAAAGAAACAGAAGTCAGGCAGAGGCGTGTCTGTGCAAACTGGAGGACTCCTTCCAACTTCCTGGAACAAAGCGACATCGCCAGCAGC
AGGCTGGCAGGGAGTGGTTGAGGTCTGGGGGCCAGGCCACATGGCTGGAGAGGAATTTCAGGGAGCATAGCATCGGGAGGATGCTACATA
TCCAGGGACTCCCTCCTGGCCTTCCTGTGTCACTTCACAATGTGACAGTCCCCAGGCATGCCCACAGGCCAGGCCCAGTCACAGCTGGGC
TTCCACAGGTCAGAATATGGGACAGGACATGGTCAGGGAGAGGACCCTGTGAGTTGGTGACATATATGTGGCAGAGATGGTAGTGTTCAG
CTGCTTCAGCAGTGTCCCCAACCATCCCAATAGGGTGGGGGCCTGTGGGCCAGAGGACTCCATGACAGTAGCCATGGAGTCCCACCTGTG
CCAGGTCAGAGCCCACCCGGCAGGTTTCAGAGTGGTCAGCCCAGTTTAAGGGTGGGAGTCTGGAGCCAGACAGCCAAGCCCCTTCCACAT
CTACAGGGTCACTGTCATCCTCACCACAGCCAGGGGTGATTCTCACCTCTGCCTGCTTATGTGGGGTGTGGCCGATTCCTCCCTTTAGTC
ATTCATTCATTTAGCACATATTTATTGGGCATCGGTGATGTGTCAGGCACAGTCCTTGGCACACAGAATACAGCAGTGAATTAAACAGGC
AAAAATTCCTCCCCTCCTGGAGCTCAGTGTCAGGAAAGGGGGTGATAAATGACAATCAAATCGACATGGAGGTTGAGCACCTCTGTACTC
AGCCCTCTGTCTGTCCTTCTGAGGACGCAACAAGCCTGGTTCCCTAGAGCTCACTTTGACCCTCAATATGTTCATAATTTCCCTGCTGCT
TCTCCCATCGTTAGACATCTGCCAGTAAGCCTGCTGAGAGAAGCCTCAGCCCACTCATACCTAGAGACGCTGCTGGGGAAGGTCAGCACA
CCCAAGAACTTTGGGAGTGTGTGTCTGTTTTGGTTTGTGAGAAAGTAGCTGCCCCTCATTCTGGCCAGTTCTTTCCAGTAGCCATGGGGC
TGGCTACAAGAAGCAAAACTGCCCATGCAAAGAGAACACAGGTCACTTTTCAAAACACTTGCATCATTACCCTAAAAATAGGCTGTTATG
CGTTTTGACAATTGCGCTATCCTACACTCTGAGGGAGTTGGCAACGCATGCGGTATAGTGGAGTGGGAAGAGTTGAGACTGAAAGTTAAG
AGAAGGGTTTTCAAGTCCCGGCTCATCTCACCCCAGTGACTTTGACAGTGTGCTCACTCTCAGAGCCATGGATTACCTGGAACAAAGTGC
AGATTAGTGCCCACGGTCCTTTCCAGGTATAACATGCTATCGTTCTTTAATTTTATTATATATACATACTTTTCTTCTGTTTTTTGCTTT
AAGAACTAACCCCGATCAAGAGTATTTTCTTTAGCTAGCTTAAAAAGAAAACATATATTTTATGTAAAAACACATACATGGCCAAATGCA
ATACTGAAGAGACAATCATCCTGTATCTTTTATGGTTTTTCCTGCTTCTGAGTGTCGTTCTACAATGCCCGTTGACTTATTCCATTGCGT
CTCTGCTTTAGGGTATGGTTTGGTCGCTTTGGTTGTCATGAGAAAGAGACATTCTCCTTGCAGCTACCTCCATGTGAGTGAATTCCTGGA


Top

FusionGenePPI for POLG_CGNL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POLGMRPL4, OXLD1, POLG2, NFATC2, NIT1, MGME1, BPNT1, OTC, NDUFS7, ACSM5, YBEY, SDHB, TSPYL6, GATCCGNL1YWHAG, YWHAZ, APC, YWHAE, TRAF7, NDE1, HMMR, GRIPAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for POLG_CGNL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for POLG_CGNL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePOLGC4225153PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE 125UNIPROT
HgenePOLGC1843851Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis14CTD_human;ORPHANET;UNIPROT
HgenePOLGC1834846Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 18CTD_human;ORPHANET;UNIPROT
HgenePOLGC0205710Alpers Syndrome (disorder)4CTD_human;ORPHANET;UNIPROT
HgenePOLGC0007795Diffuse Cerebral Sclerosis of Schilder3CTD_human
HgenePOLGC0005586Bipolar Disorder2PSYGENET
HgenePOLGC0036572Seizures2CTD_human;HPO
HgenePOLGC4277682Chemical and Drug Induced Liver Injury2CTD_human
HgenePOLGC0014544Epilepsy1CTD_human;HPO
HgenePOLGC0021364Male infertility1CTD_human
HgenePOLGC0023264Leigh Disease1UNIPROT
HgenePOLGC0162674Chronic progressive external ophthalmoplegia1CTD_human;HPO
HgenePOLGC0242422Parkinsonian Disorders1CTD_human;HPO
HgenePOLGC0525045Mood Disorders1PSYGENET
HgenePOLGC0751651Mitochondrial Diseases1CTD_human
HgenePOLGC3150914MITOCHONDRIAL DNA DEPLETION SYNDROME 4B (MNGIE TYPE)1CTD_human;ORPHANET;UNIPROT
TgeneCGNL1C0036341Schizophrenia1PSYGENET