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Fusion gene ID: 27891 |
FusionGeneSummary for POGK_FMOD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POGK_FMOD | Fusion gene ID: 27891 | Hgene | Tgene | Gene symbol | POGK | FMOD | Gene ID | 57645 | 2331 |
| Gene name | pogo transposable element derived with KRAB domain | fibromodulin | |
| Synonyms | BASS2|KRBOX2|LST003 | FM|SLRR2E | |
| Cytomap | 1q24.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pogo transposable element with KRAB domainKRAB box domain containing 2 | fibromodulinKSPG fibromodulincollagen-binding 59 kDa proteinkeratan sulfate proteoglycan fibromodulin | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9P215 | Q06828 | |
| Ensembl transtripts involved in fusion gene | ENST00000536514, ENST00000537173, ENST00000367876, ENST00000367875, | ENST00000354955, ENST00000493296, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: POGK [Title/Abstract] AND FMOD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A1FW-01A | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000536514 | ENST00000354955 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| 5CDS-5UTR | ENST00000536514 | ENST00000493296 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| Frame-shift | ENST00000537173 | ENST00000354955 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| 5CDS-5UTR | ENST00000537173 | ENST00000493296 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| In-frame | ENST00000367876 | ENST00000354955 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| 5CDS-5UTR | ENST00000367876 | ENST00000493296 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| In-frame | ENST00000367875 | ENST00000354955 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
| 5CDS-5UTR | ENST00000367875 | ENST00000493296 | POGK | chr1 | 166810325 | + | FMOD | chr1 | 203311622 | - |
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FusionProtFeatures for POGK_FMOD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POGK | FMOD |
| Affects the rate of fibrils formation. May have aprimary role in collagen fibrillogenesis (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POGK_FMOD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_POGK_ENST00000367876_chr1_166810325_+_FMOD_ENST00000354955_chr1_203311622_-_94aa MESTAYPLNLSLKEEEEEEEIQSRELEDGPADMQKVRICSEGGWSSPSAASAPWWTSXTSPSCRCCAWTGTRSSAAPCLPTRPSACALPA >In-frame_POGK_ENST00000367875_chr1_166810325_+_FMOD_ENST00000354955_chr1_203311622_-_94aa MESTAYPLNLSLKEEEEEEEIQSRELEDGPADMQKVRICSEGGWSSPSAASAPWWTSXTSPSCRCCAWTGTRSSAAPCLPTRPSACALPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_POGK_ENST00000367876_chr1_166810325_+_FMOD_ENST00000354955_chr1_203311622_-_284nt ATGGAGTCCACAGCCTACCCTCTCAATTTGAGCCTGAAAGAAGAGGAAGAGGAAGAAGAGATTCAGAGCCGGGAACTAGAGGACGGCCCG GCAGACATGCAGAAAGTACGAATCTGCTCTGAGGGCGGATGGAGTTCTCCATCAGCAGCTTCTGCACCGTGGTGGACGTCGTGAACTTCT CCAAGCTGCAGGTGCTGCGCCTGGACGGGAACGAGATCAAGCGCAGCGCCATGCCTGCCGACGCGCCCCTCTGCCTGCGCCTTGCCAGCC >In-frame_POGK_ENST00000367875_chr1_166810325_+_FMOD_ENST00000354955_chr1_203311622_-_284nt ATGGAGTCCACAGCCTACCCTCTCAATTTGAGCCTGAAAGAAGAGGAAGAGGAAGAAGAGATTCAGAGCCGGGAACTAGAGGACGGCCCG GCAGACATGCAGAAAGTACGAATCTGCTCTGAGGGCGGATGGAGTTCTCCATCAGCAGCTTCTGCACCGTGGTGGACGTCGTGAACTTCT CCAAGCTGCAGGTGCTGCGCCTGGACGGGAACGAGATCAAGCGCAGCGCCATGCCTGCCGACGCGCCCCTCTGCCTGCGCCTTGCCAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_POGK_ENST00000367876_chr1_166810325_+_FMOD_ENST00000354955_chr1_203311622_-_2149nt ACCCTCCCTCCTCCCACCACGTGTCCTCCCCGCTCCCTCCCGAGGGGCCGCGCGCACGGGAGGACGGAGAGGCGGAAAGGATGGCGCTGT GACAGCCGGGCCGGAGCCCTCGCGTCCCCACCCCGCGCCCTGGCCGCTGGGCCCGGCGAGATGGAGTCCACAGCCTACCCTCTCAATTTG AGCCTGAAAGAAGAGGAAGAGGAAGAAGAGATTCAGAGCCGGGAACTAGAGGACGGCCCGGCAGACATGCAGAAAGTACGAATCTGCTCT GAGGGCGGATGGAGTTCTCCATCAGCAGCTTCTGCACCGTGGTGGACGTCGTGAACTTCTCCAAGCTGCAGGTGCTGCGCCTGGACGGGA ACGAGATCAAGCGCAGCGCCATGCCTGCCGACGCGCCCCTCTGCCTGCGCCTTGCCAGCCTCATCGAGATCTGAGCAGCCCTGGCACCGG GTACTGGGCGGAGAGCCCCCGTGGCATTTGGCTTGATGGTTTGGTTTGGCTTTTGCTGGAAGGTCCAGGATGGACCATGTGACAGAAGTC CACGGGCACCCTCTGTAGTCTTCTTTCCTGTAGGTGGGGTTAGGGGGGGCGATCAGGGACAGGCAGCCTTCTGCTGAGGACATAGGCAGA AGCTCACTCTTTTCCAGGGACAGAAGTGGTGGTAGATGGAAGGATCCCTGGATGTTCCAACCCCATAAATCTCACGGCTCTTAAGTTCTT CCCAATGATCTGAGGTCATGGAACTTCAAAAGTGGCATGGGCAATAGTATATAACCATACTTTTCTAACAATCCCTGGCTGTCTGTGAGC AGCACTTGACAGCTCTCCCTCTGTGCTGGGCTGGTCGTGCAGTTACTCTGGGCTCCCATTTGTTGCTTCTCAAAATATACCTCTTGCCCA GCTGCCTCTTCTGAAATCCACTTCACCCACTCCACTTTCCTCCACAGATGCCTCTTCTGTGCCTTAAGCAGAGTCAGGAGACCCCAAGGC ATGTGAGCATCTGCCCAGCAACCTGTGGAGACAACCCACACTGTGTCTGAGGGTGAAAGGACACCAGGAGTCACTTCTATACCTCCCTAA CCTCACCCCTGGAAAGCCACCAGATTGGAGGTCACCAGCATGATGATAATATTCATGACCTGATGTGGGAGGAGACAGCCAACCTCAGGC TTAGATCAATGTATAGGGCTATATTTTGGCAGCTGGGTAGCTCTTTGAAGGTGGATAAGACTTCAGAAGAGGAAAGGCCAGACTTTGCTT ACCATCAGCATCTGCAATGGGCCAAACACACCTCAAATTGGCTGAGTTGAGAAAGCAGCCCCAGTAGTTCCATTCTTGCCCAGCACTTTC TGCATTCCAAACAGCATCCTACCTGGGTTTTTATCCACAAAGGTAGCGGCCACATGGTTTTTAAAGTATGAGAAACACAGTTTGTCCTCT CCTTTTATCCAAGCAGGAAGATTCTATATCCTGATGGTAGAGACAGACTCCAGGCAGCCCTGGACTTGCTAGCCCAAAGAAGGAGGATGT GGTTAATCTGTTTCACCTGGTTTGTCCTAAGGCCATAGTTAAAAAGTACCAGCTCTGGCTGGGGTCCGTGAAGCCCAGGCCAGGCAGCCA AATCTTGCCTGTGCTGGGCATACAACCCTCTGCTTTCACATCTCTGAGCTATATCCTCATTAGTGAAGGTGGCTTTTGCTTTATAGTTTG GCTGGGGAGCACTTAATTCTTCCCATTTCAAAAGGTAATGTTGCCTGGGGCTTAACCCACCTGCCCTTTGGGCAAGGTTGGGACAAAGCC ATCTGGGCAGTCAGGGGCAAGGACTGTTGGAGGAGAGTTAGCCCAAGTATAGGCTCTGCCCAGATGCCATCACATCCCTGATACTGTGTA TGCTTTGAAGCACCTTCCCTGAGAAGGGAAGAGGGGATCTTTGGACTACGTTCTTGGCTCCAGACCTGGAATCCACAAAAGCCAAACCAG CTCATTTCAACAAAGGAGCTCCGATGTGAGGGGCAAGGCTGCCCCCTGCCCCAGGGCTCTTCAGAAAGCATCTGCATGTGAACACCATCA >In-frame_POGK_ENST00000367875_chr1_166810325_+_FMOD_ENST00000354955_chr1_203311622_-_2359nt GGAAATATCGAAGGAACCGACTTTGAACTCCAGAGGGATCTTTTCTTTGGAGGTTCCCCGATGCAGCCCTCAAGATGCATCCGCACTCCA CACCTAGGAATTGCCCGCGCCCATAGAGGGCAGGAGTGCGGCCCTTTGTACTGGCCAAGAGTCAGCGAATAGAGAATTTGCAGCCCAGAG GCAATGGGTTATTTCCCTGTCGGGGTGGGCCCCAGCCGATTTCTGCACCTTTTTGGGTATCCAGGCATAACCCTCACTATGTTTCACTGA CTCCTGCGTTTGCAAAGTCCCTTAAGGTAGAATGACCCTATTTTCTGAACCAGCTCGTGGACAGAACCTTTGAATTTGGAAAATCCAGAG ATGGAGTCCACAGCCTACCCTCTCAATTTGAGCCTGAAAGAAGAGGAAGAGGAAGAAGAGATTCAGAGCCGGGAACTAGAGGACGGCCCG GCAGACATGCAGAAAGTACGAATCTGCTCTGAGGGCGGATGGAGTTCTCCATCAGCAGCTTCTGCACCGTGGTGGACGTCGTGAACTTCT CCAAGCTGCAGGTGCTGCGCCTGGACGGGAACGAGATCAAGCGCAGCGCCATGCCTGCCGACGCGCCCCTCTGCCTGCGCCTTGCCAGCC TCATCGAGATCTGAGCAGCCCTGGCACCGGGTACTGGGCGGAGAGCCCCCGTGGCATTTGGCTTGATGGTTTGGTTTGGCTTTTGCTGGA AGGTCCAGGATGGACCATGTGACAGAAGTCCACGGGCACCCTCTGTAGTCTTCTTTCCTGTAGGTGGGGTTAGGGGGGGCGATCAGGGAC AGGCAGCCTTCTGCTGAGGACATAGGCAGAAGCTCACTCTTTTCCAGGGACAGAAGTGGTGGTAGATGGAAGGATCCCTGGATGTTCCAA CCCCATAAATCTCACGGCTCTTAAGTTCTTCCCAATGATCTGAGGTCATGGAACTTCAAAAGTGGCATGGGCAATAGTATATAACCATAC TTTTCTAACAATCCCTGGCTGTCTGTGAGCAGCACTTGACAGCTCTCCCTCTGTGCTGGGCTGGTCGTGCAGTTACTCTGGGCTCCCATT TGTTGCTTCTCAAAATATACCTCTTGCCCAGCTGCCTCTTCTGAAATCCACTTCACCCACTCCACTTTCCTCCACAGATGCCTCTTCTGT GCCTTAAGCAGAGTCAGGAGACCCCAAGGCATGTGAGCATCTGCCCAGCAACCTGTGGAGACAACCCACACTGTGTCTGAGGGTGAAAGG ACACCAGGAGTCACTTCTATACCTCCCTAACCTCACCCCTGGAAAGCCACCAGATTGGAGGTCACCAGCATGATGATAATATTCATGACC TGATGTGGGAGGAGACAGCCAACCTCAGGCTTAGATCAATGTATAGGGCTATATTTTGGCAGCTGGGTAGCTCTTTGAAGGTGGATAAGA CTTCAGAAGAGGAAAGGCCAGACTTTGCTTACCATCAGCATCTGCAATGGGCCAAACACACCTCAAATTGGCTGAGTTGAGAAAGCAGCC CCAGTAGTTCCATTCTTGCCCAGCACTTTCTGCATTCCAAACAGCATCCTACCTGGGTTTTTATCCACAAAGGTAGCGGCCACATGGTTT TTAAAGTATGAGAAACACAGTTTGTCCTCTCCTTTTATCCAAGCAGGAAGATTCTATATCCTGATGGTAGAGACAGACTCCAGGCAGCCC TGGACTTGCTAGCCCAAAGAAGGAGGATGTGGTTAATCTGTTTCACCTGGTTTGTCCTAAGGCCATAGTTAAAAAGTACCAGCTCTGGCT GGGGTCCGTGAAGCCCAGGCCAGGCAGCCAAATCTTGCCTGTGCTGGGCATACAACCCTCTGCTTTCACATCTCTGAGCTATATCCTCAT TAGTGAAGGTGGCTTTTGCTTTATAGTTTGGCTGGGGAGCACTTAATTCTTCCCATTTCAAAAGGTAATGTTGCCTGGGGCTTAACCCAC CTGCCCTTTGGGCAAGGTTGGGACAAAGCCATCTGGGCAGTCAGGGGCAAGGACTGTTGGAGGAGAGTTAGCCCAAGTATAGGCTCTGCC CAGATGCCATCACATCCCTGATACTGTGTATGCTTTGAAGCACCTTCCCTGAGAAGGGAAGAGGGGATCTTTGGACTACGTTCTTGGCTC CAGACCTGGAATCCACAAAAGCCAAACCAGCTCATTTCAACAAAGGAGCTCCGATGTGAGGGGCAAGGCTGCCCCCTGCCCCAGGGCTCT TCAGAAAGCATCTGCATGTGAACACCATCATGCCTTTATAAAGGATCCTTATTACAGGAAAAGCATGAGTGGTGGCTAACCTGACCAATA |
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FusionGenePPI for POGK_FMOD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POGK | UCHL3, ELAVL1, APP, HSP90AA1, ARPC1B, TCEAL1, CCNDBP1, TRIM28, TRIM11 | FMOD | TGFB1, CUL3, BTBD1, ZBTB32, LRRC15 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POGK_FMOD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POGK_FMOD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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