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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27837

FusionGeneSummary for PNMA5_PPP1R18

check button Fusion gene summary
Fusion gene informationFusion gene name: PNMA5_PPP1R18
Fusion gene ID: 27837
HgeneTgene
Gene symbol

PNMA5

PPP1R18

Gene ID

114824

170954

Gene namePNMA family member 5protein phosphatase 1 regulatory subunit 18
Synonyms-HKMT1098|KIAA1949
Cytomap

Xq28

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionparaneoplastic antigen-like protein 5paraneoplastic Ma antigen family member 5tumor antigen BJ-HCC-25phostensinprotein phosphatase 1 F-actin cytoskeleton targeting subunit
Modification date2018051920180519
UniProtAcc

Q96PV4

Q6NYC8

Ensembl transtripts involved in fusion geneENST00000361887, ENST00000439251, 
ENST00000452693, ENST00000535214, 
ENST00000488324, ENST00000399199, 
ENST00000274853, ENST00000498031, 
ENST00000444206, ENST00000438815, 
ENST00000552716, ENST00000491628, 
ENST00000435929, ENST00000412189, 
ENST00000548255, ENST00000493833, 
ENST00000438945, ENST00000455935, 
ENST00000551049, ENST00000472334, 
ENST00000451544, ENST00000437121, 
ENST00000551034, ENST00000465704, 
ENST00000383573, ENST00000400554, 
ENST00000550073, ENST00000492746, 
ENST00000449705, ENST00000443517, 
ENST00000551784, ENST00000487859, 
ENST00000435006, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 6 X 3=72
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PNMA5 [Title/Abstract] AND PPP1R18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX390177PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361887ENST00000488324PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000399199PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000274853PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000498031PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000444206PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000438815PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000552716PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000491628PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000435929PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000412189PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000548255PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000493833PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000438945PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000455935PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000551049PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000472334PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000451544PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000437121PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000551034PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000465704PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000383573PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000400554PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000550073PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000492746PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000449705PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000443517PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000361887ENST00000551784PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-5UTRENST00000361887ENST00000487859PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-3UTRENST00000361887ENST00000435006PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000488324PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000399199PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000274853PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000498031PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000444206PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000438815PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000552716PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000491628PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000435929PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000412189PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000548255PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000493833PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000438945PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000455935PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000551049PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000472334PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000451544PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000437121PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000551034PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000465704PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000383573PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000400554PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000550073PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000492746PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000449705PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000443517PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000439251ENST00000551784PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-5UTRENST00000439251ENST00000487859PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-3UTRENST00000439251ENST00000435006PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000488324PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000399199PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000274853PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000498031PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000444206PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000438815PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000552716PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000491628PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000435929PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000412189PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000548255PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000493833PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000438945PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000455935PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000551049PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000472334PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000451544PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000437121PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000551034PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000465704PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000383573PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000400554PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000550073PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000492746PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000449705PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000443517PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000452693ENST00000551784PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-5UTRENST00000452693ENST00000487859PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-3UTRENST00000452693ENST00000435006PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000488324PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000399199PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000274853PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000498031PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000444206PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000438815PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000552716PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000491628PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000435929PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000412189PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000548255PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000493833PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000438945PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000455935PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000551049PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000472334PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000451544PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000437121PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000551034PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000465704PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000383573PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000400554PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000550073PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000492746PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000449705PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000443517PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-intronENST00000535214ENST00000551784PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-5UTRENST00000535214ENST00000487859PNMA5chrX

152159705

-PPP1R18chr6

1976835

-
intron-3UTRENST00000535214ENST00000435006PNMA5chrX

152159705

-PPP1R18chr6

1976835

-

Top

FusionProtFeatures for PNMA5_PPP1R18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PNMA5

Q96PV4

PPP1R18

Q6NYC8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PNMA5_PPP1R18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PNMA5_PPP1R18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PNMA5_PPP1R18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PNMA5_PPP1R18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPP1R18C0023893Liver Cirrhosis, Experimental1CTD_human