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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27822

FusionGeneSummary for PNISR_QRSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PNISR_QRSL1
Fusion gene ID: 27822
HgeneTgene
Gene symbol

PNISR

QRSL1

Gene ID

25957

55278

Gene namePNN interacting serine and arginine rich proteinglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
SynonymsC6orf111|HSPC306|SFRS18|SRrp130|bA98I9.2GatA
Cytomap

6q16.2

6q21

Type of geneprotein-codingprotein-coding
Descriptionarginine/serine-rich protein PNISRPNN-interacting serine/arginine-rich proteinSR-related proteinSR-rich proteinserine-arginine-rich-splicing regulatory protein 130splicing factor, arginine/serine-rich 130splicing factor, arginine/serine-rich 18glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialglu-AdT subunit Aglutaminyl-tRNA synthase-like protein 1glutamyl-tRNA(Gln) amidotransferase subunit A homologglutamyl-tRNA(Gln) amidotransferase, subunit A
Modification date2018051920180519
UniProtAcc

Q8TF01

Q9H0R6

Ensembl transtripts involved in fusion geneENST00000369239, ENST00000438806, 
ENST00000466057, 
ENST00000369046, 
ENST00000467262, ENST00000369044, 
Fusion gene scores* DoF score3 X 4 X 2=248 X 5 X 5=200
# samples 513
** MAII scorelog2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/200*10)=-0.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PNISR [Title/Abstract] AND QRSL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneQRSL1

GO:0070681

glutaminyl-tRNAGln biosynthesis via transamidation

19805282


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA841180PNISRchr6

99860426

-QRSL1chr6

107100080

+
ChiTaRS3.1CK902891PNISRchr6

99860426

-QRSL1chr6

107100080

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369239ENST00000369046PNISRchr6

99860426

-QRSL1chr6

107100080

+
5CDS-intronENST00000369239ENST00000467262PNISRchr6

99860426

-QRSL1chr6

107100080

+
5CDS-intronENST00000369239ENST00000369044PNISRchr6

99860426

-QRSL1chr6

107100080

+
Frame-shiftENST00000438806ENST00000369046PNISRchr6

99860426

-QRSL1chr6

107100080

+
5CDS-intronENST00000438806ENST00000467262PNISRchr6

99860426

-QRSL1chr6

107100080

+
5CDS-intronENST00000438806ENST00000369044PNISRchr6

99860426

-QRSL1chr6

107100080

+
intron-3CDSENST00000466057ENST00000369046PNISRchr6

99860426

-QRSL1chr6

107100080

+
intron-intronENST00000466057ENST00000467262PNISRchr6

99860426

-QRSL1chr6

107100080

+
intron-intronENST00000466057ENST00000369044PNISRchr6

99860426

-QRSL1chr6

107100080

+

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FusionProtFeatures for PNISR_QRSL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PNISR

Q8TF01

QRSL1

Q9H0R6

Allows the formation of correctly charged Gln-tRNA(Gln)through the transamidation of misacylated Glu-tRNA(Gln) in themitochondria. The reaction takes place in the presence ofglutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03150,ECO:0000269|PubMed:19805282}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PNISR_QRSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PNISR_QRSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PNISRPNN, APC, RPS24, MOV10, NXF1, HSPB1, RBM39, SETD1A, SRSF11, EWSR1, SRPK2, XPO1, CDC42, BAG3, EDEM1, PIP4K2A, CAMKV, CD2BP2QRSL1KRT8, XRCC6, GATC, GPBP1L1, GATB, USP47, ARSG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PNISR_QRSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PNISR_QRSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource