FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27772

FusionGeneSummary for PLXND1_NEK11

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXND1_NEK11
Fusion gene ID: 27772
HgeneTgene
Gene symbol

PLXND1

NEK11

Gene ID

23129

79858

Gene nameplexin D1NIMA related kinase 11
SynonymsPLEXD1-
Cytomap

3q22.1

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionplexin-D1serine/threonine-protein kinase Nek11NIMA (never in mitosis gene a)- related kinase 11
Modification date2018052320180523
UniProtAcc

Q9Y4D7

Q8NG66

Ensembl transtripts involved in fusion geneENST00000324093, ENST00000393239, 
ENST00000504689, 		ENST00000356918, 
ENST00000510769, ENST00000429253, 
ENST00000510688, ENST00000511262, 
ENST00000383366, ENST00000412440, 
ENST00000507910, ENST00000508196, 
ENST00000426022, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 3 X 4=48
# samples 54
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLXND1 [Title/Abstract] AND NEK11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEK11

GO:0006468

protein phosphorylation

15161910|19734889

TgeneNEK11

GO:0031573

intra-S DNA damage checkpoint

15161910

TgeneNEK11

GO:0035556

intracellular signal transduction

15161910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB37-01APLXND1chr3

129304795

-NEK11chr3

131068401

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000324093ENST00000356918PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000510769PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000429253PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000510688PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000511262PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000383366PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000412440PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000507910PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000508196PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000324093ENST00000426022PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000356918PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000510769PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000429253PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000510688PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000511262PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000383366PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000412440PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000507910PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000508196PLXND1chr3

129304795

-NEK11chr3

131068401

+
5CDS-intronENST00000393239ENST00000426022PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000356918PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000510769PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000429253PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000510688PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000511262PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000383366PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000412440PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000507910PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000508196PLXND1chr3

129304795

-NEK11chr3

131068401

+
intron-intronENST00000504689ENST00000426022PLXND1chr3

129304795

-NEK11chr3

131068401

+

Top

FusionProtFeatures for PLXND1_NEK11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLXND1

Q9Y4D7

NEK11

Q8NG66

Cell surface receptor for SEMA4A and for class 3semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an importantrole in cell-cell signaling, and in regulating the migration of awide spectrum of cell types. Regulates the migration of thymocytesin the medulla. Regulates endothelial cell migration. Plays animportant role in ensuring the specificity of synapse formation.Required for normal development of the heart and vasculature (Bysimilarity). Mediates anti-angiogenic signaling in response toSEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}. Protein kinase which plays an important role in the G2/Mcheckpoint response to DNA damage. Controls degradation of CDC25Aby directly phosphorylating it on residues whose phosphorylationis required for BTRC-mediated polyubiquitination and degradation.{ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889,ECO:0000269|PubMed:20090422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PLXND1_NEK11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PLXND1_NEK11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLXND1MACF1, TRIM25NEK11APP, HSP90AA1, MYC, BLM, HERC2, FKBP5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PLXND1_NEK11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNEK11Q8NG66DB08912DabrafenibSerine/threonine-protein kinase Nek11small moleculeapproved|investigational

Top

RelatedDiseases for PLXND1_NEK11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource