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Fusion gene ID: 27763 |
FusionGeneSummary for PLXNB2_TRIM25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNB2_TRIM25 | Fusion gene ID: 27763 | Hgene | Tgene | Gene symbol | PLXNB2 | TRIM25 | Gene ID | 23654 | 7706 |
| Gene name | plexin B2 | tripartite motif containing 25 | |
| Synonyms | MM1|Nbla00445|PLEXB2|dJ402G11.3 | EFP|RNF147|Z147|ZNF147 | |
| Cytomap | 22q13.33 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-B2 | E3 ubiquitin/ISG15 ligase TRIM25RING finger protein 147RING-type E3 ubiquitin transferaseRING-type E3 ubiquitin transferase TRIM25estrogen-responsive finger proteintripartite motif protein TRIM25tripartite motif-containing protein 25ubiquitin/ISG15 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O15031 | Q14258 | |
| Ensembl transtripts involved in fusion gene | ENST00000359337, ENST00000449103, ENST00000496720, | ENST00000316881, ENST00000573108, ENST00000537230, | |
| Fusion gene scores | * DoF score | 14 X 12 X 9=1512 | 4 X 5 X 2=40 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/1512*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLXNB2 [Title/Abstract] AND TRIM25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLXNB2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 16122393 |
| Hgene | PLXNB2 | GO:0010976 | positive regulation of neuron projection development | 16122393 |
| Tgene | TRIM25 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
| Tgene | TRIM25 | GO:0043627 | response to estrogen | 22452784 |
| Tgene | TRIM25 | GO:0045087 | innate immune response | 18248090 |
| Tgene | TRIM25 | GO:0046596 | regulation of viral entry into host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI492115 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000359337 | ENST00000316881 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000359337 | ENST00000573108 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000359337 | ENST00000537230 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-3CDS | ENST00000449103 | ENST00000316881 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000449103 | ENST00000573108 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000449103 | ENST00000537230 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-3CDS | ENST00000496720 | ENST00000316881 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000496720 | ENST00000573108 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000496720 | ENST00000537230 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
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FusionProtFeatures for PLXNB2_TRIM25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNB2 | TRIM25 |
| Cell surface receptor for SEMA4C, SEMA4D and SEMA4G thatplays an important role in cell-cell signaling. Binding to class 4semaphorins promotes downstream activation of RHOA andphosphorylation of ERBB2 at 'Tyr-1248'. Required for normaldifferentiation and migration of neuronal cells during braincorticogenesis and for normal embryonic brain development.Regulates the migration of cerebellar granule cells in thedeveloping brain. Plays a role in RHOA activation and subsequentchanges of the actin cytoskeleton. Plays a role in axon guidance,invasive growth and cell migration. May modulate the activity ofRAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). {ECO:0000250,ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:12533544,ECO:0000269|PubMed:15184888}. | Functions as a ubiquitin E3 ligase and as an ISG15 E3ligase. Involved in innate immune defense against viruses bymediating ubiquitination of DDX58. Mediates 'Lys-63'-linkedpolyubiquitination of the DDX58 N-terminal CARD-like region whichis crucial for triggering the cytosolic signal transduction thatleads to the production of interferons in response to viralinfection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapterprotein implicated in the regulation of a large spectrum signalingpathway. Mediates estrogen action in various target organs.Mediates the ubiquitination and subsequent proteasomal degradationof ZFHX3 (PubMed:22452784). {ECO:0000269|PubMed:16352599,ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790,ECO:0000269|PubMed:22452784}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLXNB2_TRIM25 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLXNB2_TRIM25 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNB2_TRIM25 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNB2_TRIM25 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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