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Fusion gene ID: 27739 |
FusionGeneSummary for PLXNA3_TKTL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNA3_TKTL1 | Fusion gene ID: 27739 | Hgene | Tgene | Gene symbol | PLXNA3 | TKTL1 | Gene ID | 55558 | 8277 |
| Gene name | plexin A3 | transketolase like 1 | |
| Synonyms | 6.3|HSSEXGENE|PLXN3|PLXN4|XAP-6 | TKR|TKT2 | |
| Cytomap | Xq28 | Xq28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-A3Sex chromosome X transmembrane protein of HGF receptor family 3plexin-4semaphorin receptor SEX | transketolase-like protein 1TK 2transketolase-2transketolase-related protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P51805 | P51854 | |
| Ensembl transtripts involved in fusion gene | ENST00000369682, ENST00000493546, | ENST00000369915, ENST00000217905, ENST00000369912, ENST00000482044, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: PLXNA3 [Title/Abstract] AND TKTL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-A493-01A | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369682 | ENST00000369915 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 5CDS-5UTR | ENST00000369682 | ENST00000217905 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 5CDS-5UTR | ENST00000369682 | ENST00000369912 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 5CDS-intron | ENST00000369682 | ENST00000482044 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 3UTR-3CDS | ENST00000493546 | ENST00000369915 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 3UTR-5UTR | ENST00000493546 | ENST00000217905 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 3UTR-5UTR | ENST00000493546 | ENST00000369912 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
| 3UTR-intron | ENST00000493546 | ENST00000482044 | PLXNA3 | chrX | 153698954 | + | TKTL1 | chrX | 153533656 | + |
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FusionProtFeatures for PLXNA3_TKTL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNA3 | TKTL1 |
| Coreceptor for SEMA3A and SEMA3F. Necessary forsignaling by class 3 semaphorins and subsequent remodeling of thecytoskeleton. Plays a role in axon guidance in the developingnervous system. Regulates the migration of sympathetic neurons,but not of neural crest precursors. Required for normal dendritespine morphology in pyramidal neurons. May play a role inregulating semaphorin-mediated programmed cell death in thedeveloping nervous system. Class 3 semaphorins bind to a complexcomposed of a neuropilin and a plexin. The plexin modulates theaffinity of the complex for specific semaphorins, and itscytoplasmic domain is required for the activation of down-streamsignaling events in the cytoplasm. | Catalyzes the transfer of a two-carbon ketol group froma ketose donor to an aldose acceptor, via a covalent intermediatewith the cofactor thiamine pyrophosphate. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 1023_1122 | 1718 | 1872 | Domain | Note=IPT/TIG 3 |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 1125_1211 | 1718 | 1872 | Domain | Note=IPT/TIG 4 |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 20_488 | 1718 | 1872 | Domain | Sema |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 840_933 | 1718 | 1872 | Domain | Note=IPT/TIG 1 |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 935_1020 | 1718 | 1872 | Domain | Note=IPT/TIG 2 |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 20_1220 | 1718 | 1872 | Topological domain | Extracellular |
| Hgene | PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 1221_1241 | 1718 | 1872 | Transmembrane | Helical |
| Tgene | >TKTL1 | chrX:153698954 | chrX:153533656 | ENST00000369915 | + | 0 | 13 | 94_96 | 44 | 597 | Nucleotide binding | Thiamine pyrophosphate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLXNA3 | chrX:153698954 | chrX:153533656 | ENST00000369682 | + | 30 | 33 | 1242_1871 | 1718 | 1872 | Topological domain | Cytoplasmic |
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FusionGeneSequence for PLXNA3_TKTL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLXNA3_ENST00000369682_chrX_153698954_+_TKTL1_ENST00000369915_chrX_153533656_+_2271aa MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRL APVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPT LSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDS EFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGE GTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHL YETVPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCV QVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQLLSKETGVRFAG ADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYE CVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCIS EHRCQLRTHCPAPKTNWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEE SLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSECQFVRRDAKAIVCISP LSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCK APGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQ PCSLTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQM DNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFVLTFIHTL EAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLY CAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMD LEWRQGRMTRIILQDEDVTTKIECDWKRLNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITP DQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPD VRHTWKSNCHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSD GESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKT FKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYAN NRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVG DDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITV YEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLXNA3_ENST00000369682_chrX_153698954_+_TKTL1_ENST00000369915_chrX_153533656_+_6813nt ATGCCCTCTGTCTGCCTCCTCCTGCTGCTCTTCCTTGCCGTGGGGGGGGCCCTGGGCAACAGGCCCTTCCGTGCCTTCGTGGTGACAGAC ACCACGCTTACCCACCTGGCTGTGCACCGGGTGACTGGGGAGGTGTTCGTGGGCGCAGTGAACCGAGTCTTTAAGCTGGCCCCCAACCTG ACTGAGCTGCGGGCCCATGTCACGGGGCCCGTCGAGGACAACGCTCGCTGCTACCCGCCCCCCAGCATGCGCGTGTGTGCCCACCGCCTG GCCCCCGTGGACAACATCAACAAGCTGCTGCTCATAGACTATGCGGCCCGCCGCCTGGTGGCCTGCGGCAGCATCTGGCAGGGCATCTGC CAGTTCCTGCGTCTGGACGACCTCTTCAAGCTGGGTGAGCCGCACCACCGCAAGGAGCACTACCTGTCGGGGGCCCAGGAGCCCGACTCC ATGGCTGGTGTCATTGTGGAGCAGGGCCAGGGGCCCAGCAAGCTGTTTGTGGGCACTGCTGTCGACGGCAAGTCGGAGTACTTCCCCACC TTGAGCTCCCGCAAGCTCATCAGTGATGAAGACAGCGCGGACATGTTCAGTCTCGTGTACCAGGATGAGTTTGTGTCCTCCCAGATCAAG ATCCCCTCAGACACGCTGTCCTTGTACCCTGCCTTTGACATCTACTACATCTACGGCTTCGTCAGCGCCTCCTTCGTGTACTTCCTGACG CTGCAGCTGGACACCCAGCAGACGCTGTTGGACACAGCGGGCGAGAAATTTTTCACGTCCAAGATCGTGCGCATGTGCGCGGGAGACTCA GAGTTCTACTCATACGTGGAATTCCCCATCGGCTGCTCCTGGCGCGGCGTGGAGTACCGCTTGGTGCAGAGCGCCCACCTGGCCAAGCCT GGCCTGCTGCTGGCCCAGGCCCTGGGCGTGCCGGCTGATGAGGACGTCCTCTTCACCATCTTCTCTCAGGGCCAGAAGAACCGGGCCAGC CCACCCCGGCAGACCATCCTCTGCCTCTTCACCCTCAGCAACATCAATGCCCACATCCGGCGCCGCATCCAGTCCTGCTATCGTGGGGAG GGCACTCTGGCTCTGCCCTGGCTGCTGAACAAGGAGCTGCCCTGCATCAACACCCCCATGCAGATCAACGGCAACTTCTGTGGGCTGGTG TTGAACCAGCCTCTGGGAGGCCTGCATGTGATCGAGGGGCTGCCCCTGCTGGCCGACAGCACCGACGGCATGGCCAGCGTGGCCGCCTAC ACCTACCGCCAGCACTCTGTGGTCTTCATTGGCACGCGCAGCGGCAGCTTGAAGAAGGTGCGGGTCGATGGCTTCCAGGATGCCCACCTG TATGAGACAGTCCCCGTGGTGGATGGCAGCCCCATCCTCCGAGACCTGCTCTTCAGCCCGGACCACCGGCACATCTATCTCCTGAGTGAG AAGCAGGTGAGCCAGCTCCCGGTGGAGACCTGTGAGCAGTACCAGAGCTGCGCAGCCTGCCTGGGCTCCGGGGACCCGCACTGTGGTTGG TGTGTGCTGCGACACAGGTGCTGCCGCGAAGGGGCCTGTCTGGGCGCCTCTGCCCCACACGGCTTTGCTGAGGAGCTGAGCAAGTGTGTC CAGGTGCGGGTCCGGCCCAACAATGTGTCAGTGACGTCACCTGGGGTGCAGCTGACCGTCACCCTGCACAACGTGCCAGACCTCAGTGCG GGCGTGAGCTGCGCCTTCGAGGCGGCGGCGGAGAACGAGGCGGTCCTGCTGCCCTCCGGTGAACTGCTCTGCCCCTCACCCTCCCTCCAG GAGCTCCGAGCTCTTACCAGGGGGCATGGGGCCACCCGCACTGTGCGGCTGCAGCTTCTCTCCAAGGAGACAGGCGTGAGGTTTGCCGGT GCTGACTTTGTCTTCTACAACTGCAGCGTCCTCCAGTCGTGCATGTCCTGTGTTGGCAGCCCTTACCCCTGCCACTGGTGTAAGTACCGC CACACGTGTACCAGCCGCCCCCACGAGTGCTCCTTCCAGGAGGGCAGGGTCCACAGCCCTGAGGGCTGCCCTGAGATCCTGCCCAGTGGG GACCTCCTGATCCCCGTTGGGGTCATGCAGCCTCTTACCTTGCGGGCTAAGAACCTACCTCAGCCGCAGTCGGGCCAGAAGAACTATGAG TGCGTGGTGCGGGTGCAGGGGCGGCAGCAGCGGGTGCCTGCCGTGCGCTTCAACAGCAGCAGTGTGCAGTGCCAGAACGCCTCGTACTCC TATGAAGGTGATGAGCATGGTGACACCGAGCTGGACTTCTCCGTGGTCTGGGATGGAGACTTCCCCATAGACAAGCCTCCCAGCTTCCGA GCCCTCCTGTACAAGTGCTGGGCGCAGCGGCCCAGCTGTGGCCTCTGCCTCAAGGCTGATCCCCGCTTCAACTGTGGCTGGTGCATCTCA GAGCACAGGTGCCAGCTGCGGACCCACTGCCCGGCCCCGAAGACCAACTGGATGCACCTGAGCCAGAAGGGCACCCGGTGCAGCCACCCC CGCATCACGCAGATCCACCCTCTCGTGGGGCCCAAGGAAGGAGGCACCCGGGTCACCATCGTGGGTGACAACCTGGGCCTCTTGTCCCGA GAGGTGGGCCTGCGGGTGGCTGGCGTGCGTTGCAACTCCATTCCGGCCGAGTACATCAGTGCTGAGAGGATCGTGTGTGAGATGGAGGAG TCGCTGGTGCCCAGCCCGCCGCCGGGGCCCGTGGAGCTGTGTGTGGGTGACTGTTCAGCCGACTTCCGCACGCAGTCGGAGCAGGTCTAC AGCTTTGTGACCCCAACGTTTGACCAAGTGAGTCCCAGCCGTGGCCCGGCGTCCGGGGGCACACGGCTTACCATCTCAGGCAGCTCTCTG GATGCTGGCAGCAGGGTCACAGTGACTGTGAGGGACAGCGAGTGCCAGTTTGTAAGGAGAGATGCCAAGGCGATCGTGTGCATCTCACCT CTCTCCACCCTGGGCCCCAGCCAGGCCCCCATCACACTTGCCATTGACCGGGCTAACATCTCCAGCCCCGGGCTCATCTACACCTACACT CAGGACCCCACCGTCACCCGCCTTGAGCCCACCTGGAGCATCATCAATGGAAGCACTGCCATCACTGTGAGTGGGACCCACCTGCTGACG GTCCAGGAGCCCCGGGTCCGTGCCAAGTACCGCGGCATTGAGACCACCAATACATGCCAAGTGATCAACGACACTGCCATGCTGTGTAAG GCCCCCGGCATCTTTCTTGGGCGGCCCCAGCCTCGGGCGCAAGGCGAGCACCCTGATGAGTTTGGCTTCCTGCTGGACCACGTGCAAACG GCCCGCTCCCTCAACCGCTCCTCCTTTACCTACTACCCTGATCCCAGCTTTGAGCCGCTGGGGCCCTCTGGCGTGCTGGACGTCAAACCG GGCTCCCACGTGGTGCTGAAGGGCAAGAACCTGATTCCCGCGGCAGCCGGCAGCTCCCGCCTCAACTACACTGTGCTGATAGGAGGCCAG CCGTGTTCGCTCACTGTCTCGGACACACAACTCCTGTGCGACTCACCCAGCCAGACTGGCCGGCAGCCTGTCATGGTGCTGGTGGGTGGC CTGGAGTTCTGGCTGGGCACCCTGCACATCTCGGCAGAGCGGGCGCTGACCCTACCGGCCATGATGGGGCTGGCGGCGGGGGGTGGGCTC CTGCTGCTGGCCATCACAGCCGTGCTGGTGGCGTACAAGCGCAAGACTCAGGACGCGGACCGTACCCTCAAGCGTCTGCAGCTGCAGATG GACAACCTGGAGTCCCGTGTGGCCCTGGAGTGCAAGGAAGCTTTTGCAGAGCTGCAGACGGACATCAATGAGCTGACTAACCACATGGAC GAGGTGCAGATCCCCTTCCTGGACTACCGGACTTACGCCGTGCGCGTGCTCTTCCCGGGCATCGAGGCCCACCCGGTGCTCAAGGAGCTG GATACGCCACCCAACGTGGAGAAGGCCCTGCGCCTCTTCGGGCAGCTGCTGCACAGCCGCGCGTTCGTGCTTACCTTCATCCACACGCTG GAGGCCCAGAGCAGCTTCTCCATGCGCGACCGCGGCACCGTGGCCTCGCTCACCATGGTGGCCCTGCAGAGCCGGCTCGACTATGCCACG GGGCTGCTCAAGCAACTGCTGGCCGACCTCATCGAGAAGAACCTCGAGAGCAAGAACCACCCCAAGCTGCTGCTACGCAGGACAGAGTCA GTGGCTGAGAAGATGCTTACCAACTGGTTCACGTTCCTGCTGCATAAGTTTCTGAAGGAGTGTGCTGGGGAGCCTCTCTTCCTGCTTTAC TGTGCCATCAAGCAGCAGATGGAGAAGGGCCCCATTGATGCCATCACGGGCGAGGCACGATACTCCCTGAGCGAGGACAAGCTCATCCGT CAGCAGATCGACTACAAGACACTGACCCTTCACTGCGTGTGTCCGGAGAACGAGGGCAGCGCCCAGGTCCCAGTGAAGGTTCTCAACTGT GACAGCATCACCCAGGCCAAAGATAAGCTGCTGGACACTGTGTACAAGGGCATTCCGTACTCCCAGCGTCCCAAAGCTGAGGACATGGAC CTGGAGTGGCGCCAGGGCCGCATGACTCGCATCATCCTCCAGGATGAGGATGTCACCACCAAGATCGAGTGTGACTGGAAGAGGCTCAAC TCACTGGCCCACTACCAGGTGACAGACGGTTCCTTGGTGGCATTGGTGCCCAAACAAGTGTCTGCCTATAACATGGCCAACTCCTTCACC TTCACCCGCTCCCTCAGCCGCTACGAGAGCTTGCTCCGCACGGCCAGCAGCCCTGATAGCCTCCGCTCACGGGCACCCATGATTACGCCT GACCAGGAGACAGGCACCAAATTGTGGCACCTGGTGAAAAACCACGACCATGCCGACCATCGCGAGGGGGACCGTGGCAGCAAGATGGTC TCCGAGATCTACCTGACACGGCTGCTGGCCACCAAGGGCACACTGCAGAAGTTCGTGGATGACCTCTTTGAGACAGTGTTCAGCACAGCC CACCGGGGCTCGGCCCTGCCCCTGGCCATCAAGTACATGTTCGACTTCCTGGATGAGCAGGCGGACCAGCGCCAGATCAGCGACCCCGAT GTGCGCCACACCTGGAAGAGCAACTGCCACCCTACATCATGTAGCAGTTCTTCTGAGATCATGTCTGTGCTGTTCTTCTACATCATGAGG TACAAGCAGTCAGATCCAGAGAATCCGGACAACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTC GGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCCAGCTACCGGGTGTTCTGCCTCATGAGTGAT GGCGAGTCCTCAGAAGGCTCTGTCTGGGAGGCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAAC CGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGCTGCGAAGCCTTTGGGTGGAACACTTATGTG GTGGACGGCCGGGACGTGGAGGCACTGTGCCAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATGCCGAGAGAAAGAGCAGATGCCATTATCAAA TTAATTGAGAGCCAGATACAGACCAGCAGGAATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGG ATGACCTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGTCTGGCTCTGGCTAAGCTGGGCTACGCGAAC AACAGAGTCGTTGTGCTGGATGGTGACACCAGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGC TTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACCATTGCTTTTGCTAGCACCTTTGCTGCCTTT CTGACTCGAGCATTTGATCACATCCGGATAGGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGT GACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAGTGCACGATCTTCTACCCAACTGATGCCGTC TCCACGGAGCATGCTGTTGCTCTGGCAGCCAATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAGGTCACAGTTATTGGAGCTGGAATTACTGTG TATGAAGCCTTAGCAGCTGCTGATGAGCTTTCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTC GCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCACTACCCGCAAGGTGGCATCGGGGAAGCTGTC TGCGCAGCCGTCTCCATGGATCCTGACATTCAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLXNA3_ENST00000369682_chrX_153698954_+_TKTL1_ENST00000369915_chrX_153533656_+_7650nt AGTGTGTGGGCGGCGGCGGCGGCGGCTGCGCGCTTGGGGCCCGGGGCGCGGGGCGAGGCCGTGGGGACGTGCGAGCGGGGCCGCGGTGGG GCTCGGGGGCGCGTCCACGTGGCCAGAGGGCGGCCACCCGGAGCCAGCGGAGGGACAGGCCTGTCCCCAGGCGCGGCTGCCGGCCATGCC CTCTGTCTGCCTCCTCCTGCTGCTCTTCCTTGCCGTGGGGGGGGCCCTGGGCAACAGGCCCTTCCGTGCCTTCGTGGTGACAGACACCAC GCTTACCCACCTGGCTGTGCACCGGGTGACTGGGGAGGTGTTCGTGGGCGCAGTGAACCGAGTCTTTAAGCTGGCCCCCAACCTGACTGA GCTGCGGGCCCATGTCACGGGGCCCGTCGAGGACAACGCTCGCTGCTACCCGCCCCCCAGCATGCGCGTGTGTGCCCACCGCCTGGCCCC CGTGGACAACATCAACAAGCTGCTGCTCATAGACTATGCGGCCCGCCGCCTGGTGGCCTGCGGCAGCATCTGGCAGGGCATCTGCCAGTT CCTGCGTCTGGACGACCTCTTCAAGCTGGGTGAGCCGCACCACCGCAAGGAGCACTACCTGTCGGGGGCCCAGGAGCCCGACTCCATGGC TGGTGTCATTGTGGAGCAGGGCCAGGGGCCCAGCAAGCTGTTTGTGGGCACTGCTGTCGACGGCAAGTCGGAGTACTTCCCCACCTTGAG CTCCCGCAAGCTCATCAGTGATGAAGACAGCGCGGACATGTTCAGTCTCGTGTACCAGGATGAGTTTGTGTCCTCCCAGATCAAGATCCC CTCAGACACGCTGTCCTTGTACCCTGCCTTTGACATCTACTACATCTACGGCTTCGTCAGCGCCTCCTTCGTGTACTTCCTGACGCTGCA GCTGGACACCCAGCAGACGCTGTTGGACACAGCGGGCGAGAAATTTTTCACGTCCAAGATCGTGCGCATGTGCGCGGGAGACTCAGAGTT CTACTCATACGTGGAATTCCCCATCGGCTGCTCCTGGCGCGGCGTGGAGTACCGCTTGGTGCAGAGCGCCCACCTGGCCAAGCCTGGCCT GCTGCTGGCCCAGGCCCTGGGCGTGCCGGCTGATGAGGACGTCCTCTTCACCATCTTCTCTCAGGGCCAGAAGAACCGGGCCAGCCCACC CCGGCAGACCATCCTCTGCCTCTTCACCCTCAGCAACATCAATGCCCACATCCGGCGCCGCATCCAGTCCTGCTATCGTGGGGAGGGCAC TCTGGCTCTGCCCTGGCTGCTGAACAAGGAGCTGCCCTGCATCAACACCCCCATGCAGATCAACGGCAACTTCTGTGGGCTGGTGTTGAA CCAGCCTCTGGGAGGCCTGCATGTGATCGAGGGGCTGCCCCTGCTGGCCGACAGCACCGACGGCATGGCCAGCGTGGCCGCCTACACCTA CCGCCAGCACTCTGTGGTCTTCATTGGCACGCGCAGCGGCAGCTTGAAGAAGGTGCGGGTCGATGGCTTCCAGGATGCCCACCTGTATGA GACAGTCCCCGTGGTGGATGGCAGCCCCATCCTCCGAGACCTGCTCTTCAGCCCGGACCACCGGCACATCTATCTCCTGAGTGAGAAGCA GGTGAGCCAGCTCCCGGTGGAGACCTGTGAGCAGTACCAGAGCTGCGCAGCCTGCCTGGGCTCCGGGGACCCGCACTGTGGTTGGTGTGT GCTGCGACACAGGTGCTGCCGCGAAGGGGCCTGTCTGGGCGCCTCTGCCCCACACGGCTTTGCTGAGGAGCTGAGCAAGTGTGTCCAGGT GCGGGTCCGGCCCAACAATGTGTCAGTGACGTCACCTGGGGTGCAGCTGACCGTCACCCTGCACAACGTGCCAGACCTCAGTGCGGGCGT GAGCTGCGCCTTCGAGGCGGCGGCGGAGAACGAGGCGGTCCTGCTGCCCTCCGGTGAACTGCTCTGCCCCTCACCCTCCCTCCAGGAGCT CCGAGCTCTTACCAGGGGGCATGGGGCCACCCGCACTGTGCGGCTGCAGCTTCTCTCCAAGGAGACAGGCGTGAGGTTTGCCGGTGCTGA CTTTGTCTTCTACAACTGCAGCGTCCTCCAGTCGTGCATGTCCTGTGTTGGCAGCCCTTACCCCTGCCACTGGTGTAAGTACCGCCACAC GTGTACCAGCCGCCCCCACGAGTGCTCCTTCCAGGAGGGCAGGGTCCACAGCCCTGAGGGCTGCCCTGAGATCCTGCCCAGTGGGGACCT CCTGATCCCCGTTGGGGTCATGCAGCCTCTTACCTTGCGGGCTAAGAACCTACCTCAGCCGCAGTCGGGCCAGAAGAACTATGAGTGCGT GGTGCGGGTGCAGGGGCGGCAGCAGCGGGTGCCTGCCGTGCGCTTCAACAGCAGCAGTGTGCAGTGCCAGAACGCCTCGTACTCCTATGA AGGTGATGAGCATGGTGACACCGAGCTGGACTTCTCCGTGGTCTGGGATGGAGACTTCCCCATAGACAAGCCTCCCAGCTTCCGAGCCCT CCTGTACAAGTGCTGGGCGCAGCGGCCCAGCTGTGGCCTCTGCCTCAAGGCTGATCCCCGCTTCAACTGTGGCTGGTGCATCTCAGAGCA CAGGTGCCAGCTGCGGACCCACTGCCCGGCCCCGAAGACCAACTGGATGCACCTGAGCCAGAAGGGCACCCGGTGCAGCCACCCCCGCAT CACGCAGATCCACCCTCTCGTGGGGCCCAAGGAAGGAGGCACCCGGGTCACCATCGTGGGTGACAACCTGGGCCTCTTGTCCCGAGAGGT GGGCCTGCGGGTGGCTGGCGTGCGTTGCAACTCCATTCCGGCCGAGTACATCAGTGCTGAGAGGATCGTGTGTGAGATGGAGGAGTCGCT GGTGCCCAGCCCGCCGCCGGGGCCCGTGGAGCTGTGTGTGGGTGACTGTTCAGCCGACTTCCGCACGCAGTCGGAGCAGGTCTACAGCTT TGTGACCCCAACGTTTGACCAAGTGAGTCCCAGCCGTGGCCCGGCGTCCGGGGGCACACGGCTTACCATCTCAGGCAGCTCTCTGGATGC TGGCAGCAGGGTCACAGTGACTGTGAGGGACAGCGAGTGCCAGTTTGTAAGGAGAGATGCCAAGGCGATCGTGTGCATCTCACCTCTCTC CACCCTGGGCCCCAGCCAGGCCCCCATCACACTTGCCATTGACCGGGCTAACATCTCCAGCCCCGGGCTCATCTACACCTACACTCAGGA CCCCACCGTCACCCGCCTTGAGCCCACCTGGAGCATCATCAATGGAAGCACTGCCATCACTGTGAGTGGGACCCACCTGCTGACGGTCCA GGAGCCCCGGGTCCGTGCCAAGTACCGCGGCATTGAGACCACCAATACATGCCAAGTGATCAACGACACTGCCATGCTGTGTAAGGCCCC CGGCATCTTTCTTGGGCGGCCCCAGCCTCGGGCGCAAGGCGAGCACCCTGATGAGTTTGGCTTCCTGCTGGACCACGTGCAAACGGCCCG CTCCCTCAACCGCTCCTCCTTTACCTACTACCCTGATCCCAGCTTTGAGCCGCTGGGGCCCTCTGGCGTGCTGGACGTCAAACCGGGCTC CCACGTGGTGCTGAAGGGCAAGAACCTGATTCCCGCGGCAGCCGGCAGCTCCCGCCTCAACTACACTGTGCTGATAGGAGGCCAGCCGTG TTCGCTCACTGTCTCGGACACACAACTCCTGTGCGACTCACCCAGCCAGACTGGCCGGCAGCCTGTCATGGTGCTGGTGGGTGGCCTGGA GTTCTGGCTGGGCACCCTGCACATCTCGGCAGAGCGGGCGCTGACCCTACCGGCCATGATGGGGCTGGCGGCGGGGGGTGGGCTCCTGCT GCTGGCCATCACAGCCGTGCTGGTGGCGTACAAGCGCAAGACTCAGGACGCGGACCGTACCCTCAAGCGTCTGCAGCTGCAGATGGACAA CCTGGAGTCCCGTGTGGCCCTGGAGTGCAAGGAAGCTTTTGCAGAGCTGCAGACGGACATCAATGAGCTGACTAACCACATGGACGAGGT GCAGATCCCCTTCCTGGACTACCGGACTTACGCCGTGCGCGTGCTCTTCCCGGGCATCGAGGCCCACCCGGTGCTCAAGGAGCTGGATAC GCCACCCAACGTGGAGAAGGCCCTGCGCCTCTTCGGGCAGCTGCTGCACAGCCGCGCGTTCGTGCTTACCTTCATCCACACGCTGGAGGC CCAGAGCAGCTTCTCCATGCGCGACCGCGGCACCGTGGCCTCGCTCACCATGGTGGCCCTGCAGAGCCGGCTCGACTATGCCACGGGGCT GCTCAAGCAACTGCTGGCCGACCTCATCGAGAAGAACCTCGAGAGCAAGAACCACCCCAAGCTGCTGCTACGCAGGACAGAGTCAGTGGC TGAGAAGATGCTTACCAACTGGTTCACGTTCCTGCTGCATAAGTTTCTGAAGGAGTGTGCTGGGGAGCCTCTCTTCCTGCTTTACTGTGC CATCAAGCAGCAGATGGAGAAGGGCCCCATTGATGCCATCACGGGCGAGGCACGATACTCCCTGAGCGAGGACAAGCTCATCCGTCAGCA GATCGACTACAAGACACTGACCCTTCACTGCGTGTGTCCGGAGAACGAGGGCAGCGCCCAGGTCCCAGTGAAGGTTCTCAACTGTGACAG CATCACCCAGGCCAAAGATAAGCTGCTGGACACTGTGTACAAGGGCATTCCGTACTCCCAGCGTCCCAAAGCTGAGGACATGGACCTGGA GTGGCGCCAGGGCCGCATGACTCGCATCATCCTCCAGGATGAGGATGTCACCACCAAGATCGAGTGTGACTGGAAGAGGCTCAACTCACT GGCCCACTACCAGGTGACAGACGGTTCCTTGGTGGCATTGGTGCCCAAACAAGTGTCTGCCTATAACATGGCCAACTCCTTCACCTTCAC CCGCTCCCTCAGCCGCTACGAGAGCTTGCTCCGCACGGCCAGCAGCCCTGATAGCCTCCGCTCACGGGCACCCATGATTACGCCTGACCA GGAGACAGGCACCAAATTGTGGCACCTGGTGAAAAACCACGACCATGCCGACCATCGCGAGGGGGACCGTGGCAGCAAGATGGTCTCCGA GATCTACCTGACACGGCTGCTGGCCACCAAGGGCACACTGCAGAAGTTCGTGGATGACCTCTTTGAGACAGTGTTCAGCACAGCCCACCG GGGCTCGGCCCTGCCCCTGGCCATCAAGTACATGTTCGACTTCCTGGATGAGCAGGCGGACCAGCGCCAGATCAGCGACCCCGATGTGCG CCACACCTGGAAGAGCAACTGCCACCCTACATCATGTAGCAGTTCTTCTGAGATCATGTCTGTGCTGTTCTTCTACATCATGAGGTACAA GCAGTCAGATCCAGAGAATCCGGACAACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTCGGACA AGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCCAGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGA GTCCTCAGAAGGCTCTGTCTGGGAGGCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAACCGCCT GGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGCTGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGA CGGCCGGGACGTGGAGGCACTGTGCCAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACCTTCAA GGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATGCCGAGAGAAAGAGCAGATGCCATTATCAAATTAAT TGAGAGCCAGATACAGACCAGCAGGAATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGGATGAC CTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGTCTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAG AGTCGTTGTGCTGGATGGTGACACCAGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGCTTTAT GGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACCATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGAC TCGAGCATTTGATCACATCCGGATAGGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGTGACGA TGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAGTGCACGATCTTCTACCCAACTGATGCCGTCTCCAC GGAGCATGCTGTTGCTCTGGCAGCCAATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACCCCACA AGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAGGTCACAGTTATTGGAGCTGGAATTACTGTGTATGA AGCCTTAGCAGCTGCTGATGAGCTTTCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTCGCCAC CATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCACTACCCGCAAGGTGGCATCGGGGAAGCTGTCTGCGC AGCCGTCTCCATGGATCCTGACATTCAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTGGATAT GTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAACTAAAATAGCTGTTAGCTTTGGTCTTTTGGCCTCTT TACCCTGTGTTTATGTTTGTTCCAAAACCATCATTTAAATCTCTACTGTCACATTTTGTTTCTTAAAAGCAAAGCCAGCTAACACCTTCA TTCATCCCTAGTTCGGAAATTCAAGCTAACTACTTACCCTTTAAACTGTCACTGCATATGCAAGTACCGCTCTAATTTTTGGATCATTAA AGGGAGTTACACAACTTTTAAGTGAAAAAAATAGGTAACAAAACAACCACCTGATAGTAAGTTTTCTGATAAGACTATAGATAAGTGGTA GAGGTAATCAATTCTTCCGAAGTGTTTCCTTCGTGAATAACTGGTAGAGGTAATAGTTTTTTCAATGTATTTCCTTCATGAGTAAAGAAA ATGTGGATTGAAGTATAGATTCCAGTAGCCTAGTTTCCACAGCACGATAACACCATGACGCCTACTGCTGTTCCCACCTTGGGATTCTGT GTGCTGCCATCCCACCTGCAGCTGCCCTGGAATTCCCTTCGCTGTTTGCCTTCATCTCCCTCCACGTTTGAGAGGCTGTCAGGCAGCAGC GAAAGCTTGTTAGGATGTCCTGTGCTGCTTGTGATGAGAGCCTCCACACTGTACTGTTCAAGTCAATGTTAATAAAGCATTTCAAAACCA |
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FusionGenePPI for PLXNA3_TKTL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLXNA3 | PPP2CB, MAPK8IP2, CSNK2B, TK1, SMN1, HLA-E, PTPRK, GAK, MKNK2, HSF2, MLH1, OAZ1, BAG3, SYNCRIP, EXOSC2, SPATS2L, CCDC22, PARD6A, POLK, SGTB, KIF21A, PCDHB15, SMC6, ACTR5, KLC4, CNTROB, BAG6, USF1, SCGB1D1, SCGB2A2 | TKTL1 | HSP90AB4P, DNAJB5, TUBB8, RICTOR, VSIG8, TUBA1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNA3_TKTL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNA3_TKTL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLXNA3 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
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